Drosha drosha ribonuclease III [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Droshaprovided by RGD
Official Full Name: drosha ribonuclease IIIprovided by RGD
Primary source: RGD:1307626
See related: EnsemblRapid:ENSRNOG00000013451 AllianceGenome:RGD:1307626
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Rn3; Etohi2; Rnasen; RGD1307626
Summary: Predicted to enable several functions, including DEAD/H-box RNA helicase binding activity; R-SMAD binding activity; and lipopolysaccharide binding activity. Predicted to be involved in defense response to bacterium; miRNA processing; and positive regulation of gene expression. Predicted to act upstream of or within several processes, including miRNA metabolic process; regulation of miRNA metabolic process; and regulation of regulatory T cell differentiation. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of microprocessor complex. Predicted to be active in glutamatergic synapse; nucleus; and postsynaptic density. Orthologous to human DROSHA (drosha ribonuclease III). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Brain (RPKM 83.3), Kidney (RPKM 65.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 2q16

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	2	NC_086020.1 (63591885..63703688)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	2	NC_051337.1 (61864886..61976688)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	2	NC_005101.4 (62887267..63000307)

Chromosome 2 - NC_086020.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The 24-h pattern of dgcr8, drosha, and dicer expression in the rat suprachiasmatic nuclei and peripheral tissues and its modulation by angiotensin II.
Title: The 24-h pattern of dgcr8, drosha, and dicer expression in the rat suprachiasmatic nuclei and peripheral tissues and its modulation by angiotensin II.

Submit: New GeneRIF Correction

General gene information

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Markers

Rnasen (e-PCR), detects polymorphism
- UniSTS:527519

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DEAD/H-box RNA helicase binding	ISO Inferred from Sequence Orthology more info
enables R-SMAD binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA endonuclease activity	ISO Inferred from Sequence Orthology more info
enables SMAD binding	ISO Inferred from Sequence Orthology more info
enables lipopolysaccharide binding	ISO Inferred from Sequence Orthology more info
enables primary miRNA binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables ribonuclease III activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribonuclease III activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in defense response to Gram-negative bacterium	ISO Inferred from Sequence Orthology more info
involved_in defense response to Gram-positive bacterium	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within miRNA metabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in pre-miRNA processing	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pre-miRNA processing	ISO Inferred from Sequence Orthology more info
involved_in primary miRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in primary miRNA processing	ISO Inferred from Sequence Orthology more info
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of gene expression	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of miRNA metabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of regulatory T cell differentiation	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
part_of microprocessor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of microprocessor complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic density	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ribonuclease 3

Names: drosha, ribonuclease type III; ethanol induced 2; ribonuclease III, nuclear; ribonuclease type III, nuclear

NP_001101125.2

EC 3.1.26.3

XP_006232112.2

EC 3.1.26.3

XP_038958133.1

EC 3.1.26.3

XP_038958134.1

EC 3.1.26.3

XP_038958135.1

EC 3.1.26.3

XP_063137814.1

EC 3.1.26.3

XP_063137815.1

EC 3.1.26.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001107655.2 → NP_001101125.2 ribonuclease 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000002

UniProtKB/TrEMBL

A0A8I5Y0A2, E9PTR3

Related

ENSRNOP00000076463.2, ENSRNOT00000098160.2

Conserved Domains (3) summary

PRK00102
Location:1104 → 1332

rnc; ribonuclease III; Reviewed

cd00593
Location:958 → 1078

RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...

TIGR01622
Location:212 → 274

SF-CC1; splicing factor, CC1-like family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086020.1 Reference GRCr8

Range

63591885..63703688

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006232050.5 → XP_006232112.2 ribonuclease 3 isoform X2

UniProtKB/TrEMBL

A0A8I5Y0A2

Conserved Domains (3) summary

PRK00102
Location:1096 → 1324

rnc; ribonuclease III; Reviewed

cd00593
Location:950 → 1070

RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...

TIGR01622
Location:212 → 274

SF-CC1; splicing factor, CC1-like family
XM_063281745.1 → XP_063137815.1 ribonuclease 3 isoform X3
XM_039102206.1 → XP_038958134.1 ribonuclease 3 isoform X1

UniProtKB/TrEMBL

A0A8I5Y0A2, E9PTR3

Related

ENSRNOP00000050633.5, ENSRNOT00000048026.8

Conserved Domains (3) summary

PRK00102
Location:1104 → 1332

rnc; ribonuclease III; Reviewed

cd00593
Location:958 → 1078

RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...

TIGR01622
Location:212 → 274

SF-CC1; splicing factor, CC1-like family
XM_039102207.1 → XP_038958135.1 ribonuclease 3 isoform X1

UniProtKB/TrEMBL

A0A8I5Y0A2, E9PTR3

Conserved Domains (3) summary

PRK00102
Location:1104 → 1332

rnc; ribonuclease III; Reviewed

cd00593
Location:958 → 1078

RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...

TIGR01622
Location:212 → 274

SF-CC1; splicing factor, CC1-like family
XM_063281744.1 → XP_063137814.1 ribonuclease 3 isoform X2

UniProtKB/TrEMBL

A0A8I5Y0A2
XM_039102205.1 → XP_038958133.1 ribonuclease 3 isoform X1

UniProtKB/TrEMBL

A0A8I5Y0A2, E9PTR3

Conserved Domains (3) summary

PRK00102
Location:1104 → 1332

rnc; ribonuclease III; Reviewed

cd00593
Location:958 → 1078

RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...

TIGR01622
Location:212 → 274

SF-CC1; splicing factor, CC1-like family