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    Mtmr11 myotubularin related protein 11 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 689613, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mtmr11provided by RGD
    Official Full Name
    myotubularin related protein 11provided by RGD
    Primary source
    RGD:1589965
    See related
    EnsemblRapid:ENSRNOG00000021176 AllianceGenome:RGD:1589965
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in phosphatidylinositol dephosphorylation. Predicted to be active in cytoplasm. Orthologous to human MTMR11 (myotubularin related protein 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Adrenal (RPKM 151.3), Kidney (RPKM 111.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mtmr11 in Genome Data Viewer
    Location:
    2q34
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (186410851..186421024)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (183721983..183732148)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (198301666..198311787)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134485652 Neighboring gene uncharacterized LOC134485654 Neighboring gene OTU deubiquitinase 7B Neighboring gene developmental pluripotency-associated 4, pseudogene 7 Neighboring gene splicing factor 3B subunit 4 Neighboring gene synaptic vesicle glycoprotein 2a

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Systematic analysis of myotubularins: heteromeric interactions, subcellular localisation and endosome related functions. Lorenzo O, et al. J Cell Sci, 2006 Jul 15. PMID 16787938
    2. Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry. Kang D, et al. J Proteome Res, 2008 Aug. PMID 18570454
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables phosphatidylinositol-3-phosphate phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylinositol dephosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myotubularin-related protein 11

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191096.1 → NP_001178025.1  myotubularin-related protein 11

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000002
      UniProtKB/TrEMBL
      D3ZQH5
      Related
      ENSRNOP00000053101.3, ENSRNOT00000056262.4
      Conserved Domains (3) summary
      pfam12578
      Location:553 → 683
      3-PAP; Myotubularin-associated protein
      cl17171
      Location:51 → 165
      PH-like; Pleckstrin homology-like domain
      cl21483
      Location:195 → 469
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      186410851..186421024
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008761329.4 → XP_008759551.1  myotubularin-related protein 11 isoform X2

      UniProtKB/TrEMBL
      D3ZQH5
      Conserved Domains (3) summary
      pfam12578
      Location:542 → 672
      3-PAP; Myotubularin-associated protein
      cl17171
      Location:40 → 154
      PH-like; Pleckstrin homology-like domain
      cl21483
      Location:184 → 458
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    2. XM_063282578.1 → XP_063138648.1  myotubularin-related protein 11 isoform X1

      UniProtKB/TrEMBL
      D3ZQH5

    3. XM_063282579.1 → XP_063138649.1  myotubularin-related protein 11 isoform X3

      UniProtKB/TrEMBL
      D3ZQH5

    4. XM_063282580.1 → XP_063138650.1  myotubularin-related protein 11 isoform X4

      UniProtKB/TrEMBL
      D3ZQH5
      Related
      ENSRNOP00000099302.1, ENSRNOT00000157745.1

    5. XM_063282581.1 → XP_063138651.1  myotubularin-related protein 11 isoform X5

    6. XM_063282583.1 → XP_063138653.1  myotubularin-related protein 11 isoform X7

    7. XM_063282584.1 → XP_063138654.1  myotubularin-related protein 11 isoform X8

    8. XM_063282582.1 → XP_063138652.1  myotubularin-related protein 11 isoform X6

    Nucleotide Protein Strain
    Heading Accession and Version

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