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    Ipp intracisternal A particle-promoted polypeptide [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298439, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ippprovided by RGD
    Official Full Name
    intracisternal A particle-promoted polypeptideprovided by RGD
    Primary source
    RGD:1306299
    See related
    EnsemblRapid:ENSRNOG00000016183 AllianceGenome:RGD:1306299
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in cytoplasm. Orthologous to human IPP (intracisternal A particle-promoted polypeptide). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 167.4), Spleen (RPKM 98.8) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ipp in Genome Data Viewer
    Location:
    5q35
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (135199198..135237912)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (129962528..130001237)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (135351767..135390363)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene microtubule associated serine/threonine kinase 2 Neighboring gene U6 spliceosomal RNA Neighboring gene U6 spliceosomal RNA Neighboring gene ribosomal protein L7a, pseudogene 20 Neighboring gene GC-rich promoter binding protein 1-like 1 Neighboring gene transmembrane protein 69 Neighboring gene coiled-coil domain containing 17

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    actin-binding protein IPP
    Names
    IAP promoted placental

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106679.2 → NP_001100149.2  actin-binding protein IPP

      See identical proteins and their annotated locations for NP_001100149.2

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A0A8I6ACD3, D4A1F4
      Related
      ENSRNOP00000112517.1, ENSRNOT00000148029.1
      Conserved Domains (3) summary
      PHA03098
      Location:34 → 575
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:333 → 376
      Kelch; KELCH repeat [structural motif]
      cd18256
      Location:17 → 141
      BTB_POZ_KLHL27_IPP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      135199198..135237912
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063287406.1 → XP_063143476.1  actin-binding protein IPP isoform X4

    2. XM_063287405.1 → XP_063143475.1  actin-binding protein IPP isoform X3

      UniProtKB/TrEMBL
      A0A0G2JYR6

    3. XM_006238640.5 → XP_006238702.1  actin-binding protein IPP isoform X1

      See identical proteins and their annotated locations for XP_006238702.1

      UniProtKB/TrEMBL
      A0A8I6ACD3, D4A1F4
      Conserved Domains (3) summary
      PHA03098
      Location:34 → 575
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:333 → 376
      Kelch; KELCH repeat [structural motif]
      cd18256
      Location:17 → 141
      BTB_POZ_KLHL27_IPP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP)

    4. XM_006238643.5 → XP_006238705.1  actin-binding protein IPP isoform X2

      UniProtKB/TrEMBL
      A0A8I6G2C9
      Related
      ENSRNOP00000078800.2, ENSRNOT00000106880.2
      Conserved Domains (4) summary
      PHA03098
      Location:34 → 540
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:333 → 376
      Kelch; KELCH repeat [structural motif]
      cd18256
      Location:17 → 141
      BTB_POZ_KLHL27_IPP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP)
      cd18466
      Location:134 → 236
      BACK_KLHL27_IPP; BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP)

    5. XM_006238644.5 → XP_006238706.1  actin-binding protein IPP isoform X3

      UniProtKB/TrEMBL
      A0A0G2JYR6
      Conserved Domains (5) summary
      smart00612
      Location:486 → 533
      Kelch; Kelch domain
      PHA03098
      Location:34 → 540
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:333 → 376
      Kelch; KELCH repeat [structural motif]
      pfam00651
      Location:27 → 131
      BTB; BTB/POZ domain
      pfam07707
      Location:139 → 241
      BACK; BTB And C-terminal Kelch

    6. XM_006238642.5 → XP_006238704.1  actin-binding protein IPP isoform X1

      See identical proteins and their annotated locations for XP_006238704.1

      UniProtKB/TrEMBL
      A0A8I6ACD3, D4A1F4
      Related
      ENSRNOP00000021850.5, ENSRNOT00000021850.7
      Conserved Domains (3) summary
      PHA03098
      Location:34 → 575
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:333 → 376
      Kelch; KELCH repeat [structural motif]
      cd18256
      Location:17 → 141
      BTB_POZ_KLHL27_IPP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP)

    7. XM_039109597.2 → XP_038965525.1  actin-binding protein IPP isoform X2

      UniProtKB/TrEMBL
      A0A8I6G2C9
      Conserved Domains (4) summary
      PHA03098
      Location:34 → 540
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:333 → 376
      Kelch; KELCH repeat [structural motif]
      cd18256
      Location:17 → 141
      BTB_POZ_KLHL27_IPP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP)
      cd18466
      Location:134 → 236
      BACK_KLHL27_IPP; BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP)

    8. XM_039109598.2 → XP_038965526.1  actin-binding protein IPP isoform X4

      Conserved Domains (4) summary
      smart00612
      Location:392 → 437
      Kelch; Kelch domain
      sd00038
      Location:333 → 377
      Kelch; KELCH repeat [structural motif]
      cd18256
      Location:17 → 141
      BTB_POZ_KLHL27_IPP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP)
      cd18466
      Location:134 → 236
      BACK_KLHL27_IPP; BACK (BTB and C-terminal Kelch) domain found in intracisternal A particle-promoted polypeptide (IPP)

    9. XM_063287404.1 → XP_063143474.1  actin-binding protein IPP isoform X1

      UniProtKB/TrEMBL
      A0A8I6ACD3, D4A1F4
      Related
      ENSRNOP00000070763.3, ENSRNOT00000082602.3

    10. XM_017593275.3 → XP_017448764.1  actin-binding protein IPP isoform X1

      UniProtKB/TrEMBL
      A0A8I6ACD3, D4A1F4
      Conserved Domains (3) summary
      PHA03098
      Location:34 → 575
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:333 → 376
      Kelch; KELCH repeat [structural motif]
      cd18256
      Location:17 → 141
      BTB_POZ_KLHL27_IPP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP)

    RNA

    1. XR_010066362.1 RNA Sequence

    2. XR_005504404.2 RNA Sequence

    3. XR_005504405.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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