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    Timm9 translocase of inner mitochondrial membrane 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171139, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Timm9provided by RGD
    Official Full Name
    translocase of inner mitochondrial membrane 9provided by RGD
    Primary source
    RGD:621656
    See related
    EnsemblRapid:ENSRNOG00000008222 AllianceGenome:RGD:621656
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Tim9; Tim9a; Timm9a
    Summary
    Predicted to enable membrane insertase activity; protein homodimerization activity; and protein-folding chaperone binding activity. Predicted to be involved in protein insertion into mitochondrial inner membrane. Predicted to be located in mitochondrial inner membrane and mitochondrial intermembrane space. Predicted to be part of TIM22 mitochondrial import inner membrane insertion complex and mitochondrial intermembrane space protein transporter complex. Orthologous to human TIMM9 (translocase of inner mitochondrial membrane 9). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Heart (RPKM 169.5), Kidney (RPKM 162.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Timm9 in Genome Data Viewer
    Location:
    6q24
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (95346065..95358895, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (89610094..89622924, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (93549484..93562314, complement)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene proteasome 20S subunit alpha 3 Neighboring gene AT-rich interaction domain 4A Neighboring gene translocase of outer mitochondrial membrane 20 like Neighboring gene KIAA0586 homolog Neighboring gene dishevelled-binding antagonist of beta-catenin 1 Neighboring gene similar to ATPase inhibitory factor 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The role of the TIM8-13 complex in the import of Tim23 into mitochondria. Paschen SA, et al. EMBO J, 2000 Dec 1. PMID 11101512, Free PMC Article
    2. Crystal structure of the mitochondrial chaperone TIM9.10 reveals a six-bladed alpha-propeller. Webb CT, et al. Mol Cell, 2006 Jan 6. PMID 16387659
    3. Organization and function of the small Tim complexes acting along the import pathway of metabolite carriers into mammalian mitochondria. Mühlenbein N, et al. J Biol Chem, 2004 Apr 2. PMID 14726512
    4. Assembly of β-barrel proteins in the mitochondrial outer membrane. Höhr AI, et al. Biochim Biophys Acta, 2015 Jan. PMID 25305573
    5. Integrated analysis of protein composition, tissue diversity, and gene regulation in mouse mitochondria. Mootha VK, et al. Cell, 2003 Nov 26. PMID 14651853

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables membrane insertase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-folding chaperone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein insertion into mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of TIM22 mitochondrial import inner membrane insertion complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial intermembrane space ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mitochondrial intermembrane space protein transporter complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mitochondrial import inner membrane translocase subunit Tim9
    Names
    translocase of inner mitochondrial membrane 9 homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001276429.1 → NP_001263358.1  mitochondrial import inner membrane translocase subunit Tim9

      See identical proteins and their annotated locations for NP_001263358.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      FM052814, JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q9WV97
      UniProtKB/TrEMBL
      A6HC17
      Conserved Domains (1) summary
      pfam02953
      Location:10 → 67
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    2. NM_001276430.1 → NP_001263359.1  mitochondrial import inner membrane translocase subunit Tim9

      See identical proteins and their annotated locations for NP_001263359.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      FM056491, JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q9WV97
      UniProtKB/TrEMBL
      A6HC17
      Conserved Domains (1) summary
      pfam02953
      Location:10 → 67
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    3. NM_133604.1 → NP_598288.1  mitochondrial import inner membrane translocase subunit Tim9

      See identical proteins and their annotated locations for NP_598288.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      CB775939, JAXUCZ010000006
      UniProtKB/Swiss-Prot
      Q9WV97
      UniProtKB/TrEMBL
      A6HC17
      Related
      ENSRNOP00000010871.3, ENSRNOT00000010871.7
      Conserved Domains (1) summary
      pfam02953
      Location:10 → 67
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    RNA

    1. NR_075101.1 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) lacks two alternate internal exons, compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region found in variant 1.
      Source sequence(s)
      DV726219, JAXUCZ010000006

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      95346065..95358895 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261517.1 → XP_063117587.1  mitochondrial import inner membrane translocase subunit Tim9 isoform X1

      UniProtKB/Swiss-Prot
      Q9WV97
      UniProtKB/TrEMBL
      A6HC17

    2. XM_039111743.1 → XP_038967671.1  mitochondrial import inner membrane translocase subunit Tim9 isoform X1

      UniProtKB/Swiss-Prot
      Q9WV97
      UniProtKB/TrEMBL
      A6HC17
      Conserved Domains (1) summary
      pfam02953
      Location:10 → 67
      zf-Tim10_DDP; Tim10/DDP family zinc finger

    3. XM_063261516.1 → XP_063117586.1  mitochondrial import inner membrane translocase subunit Tim9 isoform X1

      UniProtKB/Swiss-Prot
      Q9WV97
      UniProtKB/TrEMBL
      A6HC17
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WV97.3 GenPept UniProtKB/Swiss-Prot:Q9WV97

    Gene LinkOut

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