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    Gtf3c2 general transcription factor IIIC subunit 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313914, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Gtf3c2provided by RGD
    Official Full Name
    general transcription factor IIIC subunit 2provided by RGD
    Primary source
    RGD:1560392
    See related
    EnsemblRapid:ENSRNOG00000056904 AllianceGenome:RGD:1560392
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    TFIIIC110
    Summary
    Predicted to enable RNA polymerase III general transcription initiation factor activity. Predicted to contribute to DNA binding activity. Predicted to be involved in transcription by RNA polymerase III. Predicted to be located in nucleoplasm. Predicted to be part of transcription factor TFIIIC complex. Orthologous to human GTF3C2 (general transcription factor IIIC subunit 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Thymus (RPKM 223.7), Kidney (RPKM 177.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Gtf3c2 in Genome Data Viewer
    Location:
    6q14
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 6 NC_086024.1 (30913263..30941305)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 6 NC_051341.1 (25196439..25221338)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 6 NC_005105.4 (26560601..26584533)

    Chromosome 6 - NC_086024.1Genomic Context describing neighboring genes Neighboring gene sorting nexin 17 Neighboring gene eukaryotic translation initiation factor 2B subunit delta Neighboring gene mitochondrial inner membrane protein MPV17 Neighboring gene urocortin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification, molecular cloning, and characterization of the sixth subunit of human transcription factor TFIIIC. Dumay-Odelot H, et al. J Biol Chem, 2007 Jun 8. PMID 17409385
    2. A structural perspective on RNA polymerase I and RNA polymerase III transcription machineries. Vannini A. Biochim Biophys Acta, 2013 Mar-Apr. PMID 23031840
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    contributes_to DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase III general transcription initiation factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in transcription by RNA polymerase III IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase III ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription factor TFIIIC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of transcription factor TFIIIC complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    general transcription factor 3C polypeptide 2
    Names
    general transcription factor IIIC, polypeptide 2, beta 110kDa

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025120.1 → NP_001020291.1  general transcription factor 3C polypeptide 2

      See identical proteins and their annotated locations for NP_001020291.1

      Status: PROVISIONAL

      Source sequence(s)
      BC087088
      UniProtKB/TrEMBL
      A0A0G2JY75, A0A8I6A405, Q5PQP7
      Related
      ENSRNOP00000070546.2, ENSRNOT00000077481.3
      Conserved Domains (3) summary
      PHA03247
      Location:54 → 268
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:598 → 635
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:599 → 684
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086024.1 Reference GRCr8

      Range
      30913263..30941305
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063261868.1 → XP_063117938.1  general transcription factor 3C polypeptide 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A405

    2. XM_063261864.1 → XP_063117934.1  general transcription factor 3C polypeptide 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JY75, A0A8I6A405, Q5PQP7

    3. XM_063261872.1 → XP_063117942.1  general transcription factor 3C polypeptide 2 isoform X7

      UniProtKB/TrEMBL
      A6HA72

    4. XM_063261871.1 → XP_063117941.1  general transcription factor 3C polypeptide 2 isoform X6

      UniProtKB/TrEMBL
      A6HA72

    5. XM_063261873.1 → XP_063117943.1  general transcription factor 3C polypeptide 2 isoform X8

      UniProtKB/TrEMBL
      A6HA72

    6. XM_063261866.1 → XP_063117936.1  general transcription factor 3C polypeptide 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K679, A0A8I6A405
      Related
      ENSRNOP00000073708.2, ENSRNOT00000079292.3

    7. XM_063261869.1 → XP_063117939.1  general transcription factor 3C polypeptide 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A405

    8. XM_063261867.1 → XP_063117937.1  general transcription factor 3C polypeptide 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K679, A0A8I6A405

    9. XM_039112172.2 → XP_038968100.1  general transcription factor 3C polypeptide 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K679, A0A8I6A405
      Conserved Domains (3) summary
      PHA03247
      Location:54 → 295
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:555 → 592
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:556 → 641
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    10. XM_039112170.2 → XP_038968098.1  general transcription factor 3C polypeptide 2 isoform X2

      UniProtKB/TrEMBL
      A0A0G2K679, A0A8I6A405
      Conserved Domains (3) summary
      PHA03247
      Location:54 → 295
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:555 → 592
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:556 → 641
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    11. XM_063261870.1 → XP_063117940.1  general transcription factor 3C polypeptide 2 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A405

    12. XM_063261865.1 → XP_063117935.1  general transcription factor 3C polypeptide 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JY75, A0A8I6A405, Q5PQP7

    13. XM_039112168.2 → XP_038968096.1  general transcription factor 3C polypeptide 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JY75, A0A8I6A405, Q5PQP7
      Conserved Domains (3) summary
      PHA03247
      Location:54 → 268
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:598 → 635
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:599 → 684
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    14. XM_039112169.2 → XP_038968097.1  general transcription factor 3C polypeptide 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JY75, A0A8I6A405, Q5PQP7
      Conserved Domains (3) summary
      PHA03247
      Location:54 → 268
      PHA03247; large tegument protein UL36; Provisional
      sd00039
      Location:598 → 635
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:599 → 684
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    15. XM_039112173.2 → XP_038968101.1  general transcription factor 3C polypeptide 2 isoform X5

      Conserved Domains (2) summary
      sd00039
      Location:265 → 302
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:266 → 351
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    Nucleotide Protein Strain
    Heading Accession and Version

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