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    Rbms2 RNA binding motif, single stranded interacting protein 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 288771, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Rbms2provided by RGD
    Official Full Name
    RNA binding motif, single stranded interacting protein 2provided by RGD
    Primary source
    RGD:1304813
    See related
    EnsemblRapid:ENSRNOG00000003076 AllianceGenome:RGD:1304813
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable mRNA 3'-UTR binding activity; poly(A) binding activity; and poly(U) RNA binding activity. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytosol and nucleus. Orthologous to human RBMS2 (RNA binding motif single stranded interacting protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Lung (RPKM 129.6), Heart (RPKM 94.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Rbms2 in Genome Data Viewer
    Location:
    7q11
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (1145240..1201690, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (560787..603881, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (2550524..2592533, complement)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD59 Neighboring gene small nucleolar RNA, C/D box 59A Neighboring gene ATP synthase F1 subunit beta Neighboring gene bromodomain adjacent to zinc finger domain, 2A Neighboring gene glutaminase 2 Neighboring gene SPRY domain containing 4 Neighboring gene major intrinsic protein of lens fiber

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The mRNA-bound proteome and its global occupancy profile on protein-coding transcripts. Baltz AG, et al. Mol Cell, 2012 Jun 8. PMID 22681889
    2. Insights into RNA biology from an atlas of mammalian mRNA-binding proteins. Castello A, et al. Cell, 2012 Jun 8. PMID 22658674
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables mRNA 3'-UTR binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(A) binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables poly(U) RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    RNA-binding motif, single-stranded-interacting protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025403.1 → NP_001020574.1  RNA-binding motif, single-stranded-interacting protein 2

      See identical proteins and their annotated locations for NP_001020574.1

      Status: PROVISIONAL

      Source sequence(s)
      BC097377
      UniProtKB/TrEMBL
      A0A8I6A6C0, Q4QR81
      Related
      ENSRNOP00000106127.1, ENSRNOT00000140040.1
      Conserved Domains (2) summary
      cd12471
      Location:49 → 132
      RRM1_MSSP2; RNA recognition motif 1 (RRM1) found in vertebrate single-stranded DNA-binding protein MSSP-2
      cd12474
      Location:133 → 218
      RRM2_MSSP2; RNA recognition motif 2 (RRM2) found in vertebrate single-stranded DNA-binding protein MSSP-2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      1145240..1201690 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063263087.1 → XP_063119157.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A6C0, Q4QR81

    2. XM_063263086.1 → XP_063119156.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A6C0, Q4QR81

    3. XM_006240744.5 → XP_006240806.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X4

      See identical proteins and their annotated locations for XP_006240806.1

      Conserved Domains (2) summary
      cd12474
      Location:105 → 190
      RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
      cl17169
      Location:19 → 104
      RRM_SF; RNA recognition motif (RRM) superfamily

    4. XM_063263084.1 → XP_063119154.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYJ7, A0A8I6A6C0

    5. XM_039078542.2 → XP_038934470.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A6C0, Q4QR81
      Conserved Domains (2) summary
      cd12471
      Location:49 → 132
      RRM1_MSSP2; RNA recognition motif 1 (RRM1) found in vertebrate single-stranded DNA-binding protein MSSP-2
      cd12474
      Location:133 → 218
      RRM2_MSSP2; RNA recognition motif 2 (RRM2) found in vertebrate single-stranded DNA-binding protein MSSP-2

    6. XM_063263085.1 → XP_063119155.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A0G2JYJ7, A0A8I6A6C0
      Related
      ENSRNOP00000070681.1, ENSRNOT00000088619.3

    7. XM_039078544.2 → XP_038934472.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A6C0, F7EVG9
      Related
      ENSRNOP00000086945.2, ENSRNOT00000118787.2
      Conserved Domains (2) summary
      cd12471
      Location:49 → 132
      RRM1_MSSP2; RNA recognition motif 1 (RRM1) found in vertebrate single-stranded DNA-binding protein MSSP-2
      cd12474
      Location:133 → 218
      RRM2_MSSP2; RNA recognition motif 2 (RRM2) found in vertebrate single-stranded DNA-binding protein MSSP-2

    8. XM_039078543.2 → XP_038934471.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A6C0
      Conserved Domains (2) summary
      cd12471
      Location:49 → 132
      RRM1_MSSP2; RNA recognition motif 1 (RRM1) found in vertebrate single-stranded DNA-binding protein MSSP-2
      cd12474
      Location:133 → 218
      RRM2_MSSP2; RNA recognition motif 2 (RRM2) found in vertebrate single-stranded DNA-binding protein MSSP-2

    9. XM_008765023.4 → XP_008763245.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X4

      See identical proteins and their annotated locations for XP_008763245.1

      Conserved Domains (2) summary
      cd12474
      Location:105 → 190
      RRM2_MSSP2; RNA recognition motif 2 found in vertebrate single-stranded DNA-binding protein MSSP-2
      cl17169
      Location:19 → 104
      RRM_SF; RNA recognition motif (RRM) superfamily

    10. XM_039078546.2 → XP_038934474.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X7

      Conserved Domains (1) summary
      cl17169
      Location:14 → 52
      RRM_SF; RNA recognition motif (RRM) superfamily

    11. XM_063263088.1 → XP_063119158.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X8

    12. XM_039078545.2 → XP_038934473.1  RNA-binding motif, single-stranded-interacting protein 2 isoform X6

      Conserved Domains (2) summary
      cd12471
      Location:49 → 132
      RRM1_MSSP2; RNA recognition motif 1 (RRM1) found in vertebrate single-stranded DNA-binding protein MSSP-2
      cl17169
      Location:133 → 179
      RRM_SF; RNA recognition motif (RRM) superfamily

    RNA

    1. XR_010052944.1 RNA Sequence

    2. XR_001838668.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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