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    Odad3 outer dynein arm docking complex subunit 3 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 315465, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Odad3provided by RGD
    Official Full Name
    outer dynein arm docking complex subunit 3provided by RGD
    Primary source
    RGD:1310048
    See related
    EnsemblRapid:ENSRNOG00000013263 AllianceGenome:RGD:1310048
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Ccdc151; RGD1310048
    Summary
    Predicted to be involved in cilium movement; outer dynein arm assembly; and regulation of cilium assembly. Predicted to act upstream of or within several processes, including determination of heart left/right asymmetry; epithelial cilium movement involved in extracellular fluid movement; and flagellated sperm motility. Predicted to be located in axoneme and centriole. Predicted to be active in ciliary basal body; ciliary rootlet; and ciliary tip. Human ortholog(s) of this gene implicated in primary ciliary dyskinesia 30. Orthologous to human ODAD3 (outer dynein arm docking complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Testes (RPKM 65.7), Adrenal (RPKM 9.9) and 1 other tissue See more
    Orthologs
    human mouse all
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    Genomic context

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    See Odad3 in Genome Data Viewer
    Location:
    8q13
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (28796909..28810587, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (20520898..20534499, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (23000912..23014707, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene erythropoietin receptor Neighboring gene ral guanine nucleotide dissociation stimulator like 3 Neighboring gene uncharacterized LOC134480147 Neighboring gene PRKCSH beta subunit of glucosidase II Neighboring gene ELAV like RNA binding protein 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The coiled-coil domain containing protein CCDC151 is required for the function of IFT-dependent motile cilia in animals. Jerber J, et al. Hum Mol Genet, 2014 Feb 1. PMID 24067530
    2. CCDC151 mutations cause primary ciliary dyskinesia by disruption of the outer dynein arm docking complex formation. Hjeij R, et al. Am J Hum Genet, 2014 Sep 4. PMID 25192045, Free PMC Article
    3. Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Li Y, et al. Nature, 2015 May 28. PMID 25807483, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of_or_within brain development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cerebrospinal fluid circulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cilium movement IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cilium movement ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within determination of heart left/right asymmetry ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within determination of left/right symmetry ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within epithelial cilium movement involved in determination of left/right asymmetry ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within flagellated sperm motility ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within heart development ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within multicellular organism growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in outer dynein arm assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within outer dynein arm assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in outer dynein arm assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cilium assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in axoneme ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centriole ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ciliary basal body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in ciliary basal body ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in ciliary rootlet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in ciliary tip IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cilium ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    outer dynein arm-docking complex subunit 3
    Names
    coiled-coil domain containing 151
    coiled-coil domain-containing protein 151

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001309457.1 → NP_001296386.1  outer dynein arm-docking complex subunit 3

      See identical proteins and their annotated locations for NP_001296386.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A6JNX0, D4ABL9
      Related
      ENSRNOP00000017820.7, ENSRNOT00000017820.8
      Conserved Domains (1) summary
      COG1196
      Location:63 → 450
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      28796909..28810587 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063265339.1 → XP_063121409.1  outer dynein arm-docking complex subunit 3 isoform X2

      UniProtKB/TrEMBL
      D4ABL9
      Related
      ENSRNOP00000098818.1, ENSRNOT00000164436.1

    2. XM_063265340.1 → XP_063121410.1  outer dynein arm-docking complex subunit 3 isoform X3

      UniProtKB/TrEMBL
      D4ABL9

    3. XM_063265338.1 → XP_063121408.1  outer dynein arm-docking complex subunit 3 isoform X1

      UniProtKB/TrEMBL
      D4ABL9

    4. XM_063265341.1 → XP_063121411.1  outer dynein arm-docking complex subunit 3 isoform X4

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108130.1: Suppressed sequence

      Description
      NM_001108130.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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