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    Srgn serglycin [ Mus musculus (house mouse) ]

    Gene ID: 19073, updated on 9-Dec-2024

    Summary

    Official Symbol
    Srgnprovided by MGI
    Official Full Name
    serglycinprovided by MGI
    Primary source
    MGI:MGI:97756
    See related
    Ensembl:ENSMUSG00000020077 AllianceGenome:MGI:97756
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Prg; Sgc; Prg1
    Summary
    Predicted to enable collagen binding activity. Involved in negative regulation of cytokine production; protein localization to secretory granule; and protein processing. Located in mast cell granule. Is expressed in several structures, including autopod; central nervous system; liver; lower jaw; and thymus primordium. Orthologous to human SRGN (serglycin). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in placenta adult (RPKM 7.7), spleen adult (RPKM 6.2) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Srgn in Genome Data Viewer
    Location:
    10 B4; 10 32.42 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (62329612..62363224, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (62493833..62527445, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene suppressor of var1, 3-like 1 (S. cerevisiae) Neighboring gene RIKEN cDNA 4930507D05 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:61912425-61912612 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:61912686-61912869 Neighboring gene VPS26 retromer complex component A Neighboring gene STARR-seq mESC enhancer starr_26885 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:61949721-61949830 Neighboring gene STARR-seq mESC enhancer starr_26886 Neighboring gene STARR-positive B cell enhancer ABC_E6862 Neighboring gene STARR-positive B cell enhancer ABC_E6863 Neighboring gene STARR-positive B cell enhancer ABC_E6864 Neighboring gene STARR-positive B cell enhancer ABC_E10614 Neighboring gene STARR-positive B cell enhancer ABC_E2327 Neighboring gene STARR-positive B cell enhancer ABC_E11441 Neighboring gene STARR-seq mESC enhancer starr_26888 Neighboring gene kinesin family binding protein Neighboring gene STARR-positive B cell enhancer ABC_E3889 Neighboring gene STARR-positive B cell enhancer ABC_E8339 Neighboring gene DExD box helicase 21

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytolytic granule IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in mast cell granule IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in secretory granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in zymogen granule ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    serglycin
    Names
    gp600
    mastocytoma proteoglycan core protein
    proteoglycan 1, secretory granule
    proteoglycan, secretory granule
    secretory granule proteoglycan core protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358965.2NP_001345894.1  serglycin isoform b precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) contains an alternate exon in its 5' UTR, compared to variant 1. Variants 1-3 all encode the same isoform (b).
      Source sequence(s)
      AC126428
      Consensus CDS
      CCDS23889.1
      UniProtKB/Swiss-Prot
      P13609, Q3TZD4, Q8C2U2
      Related
      ENSMUSP00000125622.2, ENSMUST00000160987.8
      Conserved Domains (1) summary
      pfam04360
      Location:3148
      Serglycin
    2. NM_001428754.1NP_001415683.1  serglycin isoform b precursor

      Status: VALIDATED

      Source sequence(s)
      AC126428
      UniProtKB/Swiss-Prot
      P13609, Q3TZD4, Q8C2U2
    3. NM_001428755.1NP_001415684.1  serglycin isoform a

      Status: VALIDATED

      Source sequence(s)
      AC126428
    4. NM_011157.4NP_035287.1  serglycin isoform b precursor

      See identical proteins and their annotated locations for NP_035287.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the predominant but shortest transcript and encodes isoform b. It has a transcriptional start site that is internal relative to that of the other variants. Variants 1-3 all encode the same isoform (b).
      Source sequence(s)
      AC126428
      Consensus CDS
      CCDS23889.1
      UniProtKB/Swiss-Prot
      P13609, Q3TZD4, Q8C2U2
      Related
      ENSMUSP00000020271.7, ENSMUST00000020271.13
      Conserved Domains (1) summary
      pfam04360
      Location:3148
      Serglycin

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      62329612..62363224 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513377.5XP_006513440.1  serglycin isoform X2

      Conserved Domains (1) summary
      pfam04360
      Location:3148
      Serglycin
    2. XM_030244954.1XP_030100814.1  serglycin isoform X2

      UniProtKB/Swiss-Prot
      P13609, Q3TZD4, Q8C2U2
      Conserved Domains (1) summary
      pfam04360
      Location:3148
      Serglycin
    3. XM_006513376.5XP_006513439.1  serglycin isoform X2

      See identical proteins and their annotated locations for XP_006513439.1

      UniProtKB/Swiss-Prot
      P13609, Q3TZD4, Q8C2U2
      Conserved Domains (1) summary
      pfam04360
      Location:3148
      Serglycin
    4. XM_030244953.1XP_030100813.1  serglycin isoform X2

      UniProtKB/Swiss-Prot
      P13609, Q3TZD4, Q8C2U2
      Conserved Domains (1) summary
      pfam04360
      Location:3148
      Serglycin
    5. XM_006513374.5XP_006513437.1  serglycin isoform X1

      Conserved Domains (1) summary
      pfam04360
      Location:45190
      Serglycin