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    Hepacam hepatic and glial cell adhesion molecule [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300517, updated on 27-Nov-2024

    Summary

    Official Symbol
    Hepacamprovided by RGD
    Official Full Name
    hepatic and glial cell adhesion moleculeprovided by RGD
    Primary source
    RGD:1306811
    See related
    EnsemblRapid:ENSRNOG00000009219 AllianceGenome:RGD:1306811
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1306811
    Summary
    Predicted to be involved in protein localization to cell-cell junction. Predicted to act upstream of or within protein localization. Predicted to be located in astrocyte end-foot; cell-cell junction; and membrane. Human ortholog(s) of this gene implicated in megalencephalic leukoencephalopathy with subcortical cysts 2A and megalencephalic leukoencephalopathy with subcortical cysts 2B. Orthologous to human HEPACAM (hepatic and glial cell adhesion molecule). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 39.0), Testes (RPKM 4.4) and 1 other tissue See more
    Orthologs
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    Genomic context

    See Hepacam in Genome Data Viewer
    Location:
    8q22
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (45276594..45294006)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (37087864..37106759)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (39848264..39866969)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 37 member 2 Neighboring gene coiled-coil domain containing 15 Neighboring gene transfer RNA proline (anticodon AGG) 64 Neighboring gene uncharacterized LOC120094115 Neighboring gene roundabout guidance receptor 4 Neighboring gene roundabout guidance receptor 3 Neighboring gene uncharacterized LOC102549473 Neighboring gene Myb/SANT DNA binding domain containing 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    General gene information

    Markers

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein localization to cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in astrocyte end-foot ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cell-cell junction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endomembrane system IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    hepatic and glial cell adhesion molecule
    Names
    hepatocyte cell adhesion molecule

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001429434.1NP_001416363.1  hepatic and glial cell adhesion molecule isoform 1 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      A0A8I6B3X3
    2. NM_001429435.1NP_001416364.1  hepatic and glial cell adhesion molecule isoform 2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
    3. NM_001429436.1NP_001416365.1  hepatic and glial cell adhesion molecule isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      45276594..45294006
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039082304.2XP_038938232.1  hepatic and glial cell adhesion molecule isoform X1

      Related
      ENSRNOP00000096251.1, ENSRNOT00000107950.2
      Conserved Domains (3) summary
      cl29975
      Location:324383
      Herpes_UL1; Herpesvirus glycoprotein L
      cd00096
      Location:4345
      Ig; Ig strand A [structural motif]
      cl11960
      Location:43141
      Ig; Immunoglobulin domain
    2. XM_063266297.1XP_063122367.1  hepatic and glial cell adhesion molecule isoform X2