Mrap melanocortin 2 receptor accessory protein [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Mrapprovided by MGI
Official Full Name: melanocortin 2 receptor accessory proteinprovided by MGI
Primary source: MGI:MGI:1924287
See related: Ensembl:ENSMUSG00000039956 AllianceGenome:MGI:1924287
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Falp; ORF61; C21ORF61; 1110025G12Rik
Summary: Predicted to enable identical protein binding activity; melanocortin receptor binding activity; and signaling receptor regulator activity. Acts upstream of or within brown fat cell differentiation. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in endoplasmic reticulum and plasma membrane. Is expressed in several structures, including brain; exocrine system; olfactory epithelium; respiratory system; and urinary system. Used to study adrenal gland disease. Human ortholog(s) of this gene implicated in familial glucocorticoid deficiency. Orthologous to human MRAP (melanocortin 2 receptor accessory protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in adrenal adult (RPKM 314.9), subcutaneous fat pad adult (RPKM 188.2) and 6 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C3.3; 16 51.9 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (90535095..90546673)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (90738207..90749785)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Selective Interactions of Mouse Melanocortin Receptor Accessory Proteins with Somatostatin Receptors.
Title: Selective Interactions of Mouse Melanocortin Receptor Accessory Proteins with Somatostatin Receptors.
Data (including data from studies in transgenic mice) suggest that Mrap plays critical role in (1) regulation of lipolysis in adipose tissue, (2) regulation of enzyme expression in adipose tissue, and (3) whole-body energy balance.
Title: Regulation of Lipolytic Response and Energy Balance by Melanocortin 2 Receptor Accessory Protein (MRAP) in Adipocytes.
These results suggest that PPARgamma is required for transcriptional activation of the MRAP gene during adipogenesis, which contributes to understanding of the molecular mechanism of lipolysis in adipocytes.
Title: Transcriptional activation of melanocortin 2 receptor accessory protein by PPARγ in adipocytes.
The receptor was co-expressed with a cartilaginous fish (Callorhinchus milii) MRAP2 cDNA.
Title: Functional expression of Squalus acanthias melanocortin-5 receptor in CHO cells: ligand selectivity and interaction with MRAP.
C-terminal tail of the MC(4) receptor with the corresponding regions from the MC(2) receptor resulted in MRAP-dependent signaling
Title: Use of chimeric melanocortin-2 and -4 receptors to identify regions responsible for ligand specificity and dependence on melanocortin 2 receptor accessory protein.
The results establish that MRAP forms stable complexes with two different melanocortin receptors, facilitating surface expression of MC2 receptor but disrupting dimerization and surface localization of MC5 receptor.
Title: Opposite effects of the melanocortin-2 (MC2) receptor accessory protein MRAP on MC2 and MC5 receptor dimerization and trafficking.
MRAP not only facilitates MC2 receptor trafficking but also allows properly localized receptor to bind ACTH and consequently signal.
Title: Regions of melanocortin 2 (MC2) receptor accessory protein necessary for dual topology and MC2 receptor trafficking and signaling.
The melanocortin 2 receptor accessory protein exists as a homodimer and is essential for the function of the melanocortin 2 receptor in the mouse y1 cell line.
Title: The melanocortin 2 receptor accessory protein exists as a homodimer and is essential for the function of the melanocortin 2 receptor in the mouse y1 cell line.
Falp protein strictly localizes at a compact perinuclear membrane compartment (Falp protein)
Title: Identification of novel putative membrane proteins selectively expressed during adipose conversion of 3T3-L1 cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables corticotropin hormone receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables corticotropin hormone receptor binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables signaling receptor regulator activity	IBA Inferred from Biological aspect of Ancestor more info
enables type 1 melanocortin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 1 melanocortin receptor binding	ISO Inferred from Sequence Orthology more info
enables type 3 melanocortin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 3 melanocortin receptor binding	ISO Inferred from Sequence Orthology more info
enables type 4 melanocortin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 4 melanocortin receptor binding	ISO Inferred from Sequence Orthology more info
enables type 5 melanocortin receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type 5 melanocortin receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within brown fat cell differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: melanocortin-2 receptor accessory protein

Names: fat cell-specific low molecular weight protein; fat tissue-specific low MW protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_029844.4 → NP_084120.1 melanocortin-2 receptor accessory protein

See identical proteins and their annotated locations for NP_084120.1

Status: VALIDATED

Source sequence(s)

AC126671

Consensus CDS

CCDS28317.1

UniProtKB/Swiss-Prot

Q3TZ49, Q8R439, Q9D159

Related

ENSMUSP00000043890.3, ENSMUST00000038197.3

Conserved Domains (1) summary

pfam15183
Location:1 → 89

MRAP; Melanocortin-2 receptor accessory protein family

RNA

NR_155757.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC126671
NR_155758.1 RNA Sequence

Status: VALIDATED

Source sequence(s)

AC126671

Related

ENSMUST00000125429.3