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    Gpc2 glypican 2 cerebroglycan [ Mus musculus (house mouse) ]

    Gene ID: 71951, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Gpc2provided by MGI
    Official Full Name
    glypican 2 cerebroglycanprovided by MGI
    Primary source
    MGI:MGI:1919201
    See related
    Ensembl:ENSMUSG00000029510 AllianceGenome:MGI:1919201
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2410016G05Rik
    Summary
    Predicted to be involved in several processes, including positive regulation of neuron projection development; regulation of protein localization to membrane; and smoothened signaling pathway. Predicted to be located in endoplasmic reticulum. Predicted to be active in cell surface and synapse. Is expressed in several structures, including branchial arch; lower jaw; nervous system; reproductive system; and sensory organ. Orthologous to human GPC2 (glypican 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E14 (RPKM 130.8), whole brain E14.5 (RPKM 125.9) and 3 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Gpc2 in Genome Data Viewer
    Location:
    5 G2; 5 77.0 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (138271918..138278288, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (138273657..138280026, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 6330418K02 gene Neighboring gene STARR-positive B cell enhancer ABC_E4800 Neighboring gene trafficking protein particle complex 14 Neighboring gene galactose-3-O-sulfotransferase 4 Neighboring gene STARR-positive B cell enhancer ABC_E3630 Neighboring gene STAG3 cohesin complex component Neighboring gene poliovirus receptor related immunoglobulin domain containing Neighboring gene poliovirus receptor related immunoglobulin domain containing, pseudogene Neighboring gene glutamatic-oxaloacetic transaminase 2, mitochondrial, pseudogene 1 Neighboring gene predicted gene 10874

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Glypican-2 levels in cerebrospinal fluid predict the status of adult hippocampal neurogenesis. Lugert S, et al. Sci Rep, 2017 Apr 25. PMID 28440309, Free PMC Article
    2. Glypican-1 controls brain size through regulation of fibroblast growth factor signaling in early neurogenesis. Jen YH, et al. Neural Dev, 2009 Sep 4. PMID 19732411, Free PMC Article
    3. Glypicans are differentially expressed during patterning and neurogenesis of early mouse brain. Luxardi G, et al. Biochem Biophys Res Commun, 2007 Jan 5. PMID 17107664
    4. Localisation of specific heparan sulfate proteoglycans during the proliferative phase of brain development. Ford-Perriss M, et al. Dev Dyn, 2003 Jun. PMID 12761845
    5. Spatiotemporal Localisation of Heparan Sulphate Proteoglycans throughout Mouse Lens Morphogenesis. Wishart TFL, et al. Cells, 2023 May 11. PMID 37408198, Free PMC Article

    See all (30) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (3)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC90563

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron projection development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of protein localization to membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in smoothened signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in smoothened signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in smoothened signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi lumen TAS
    Traceable Author Statement
    more info
    		  
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in collagen-containing extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in side of membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    glypican-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001417777.1 → NP_001404706.1  glypican-2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC159257

    2. NM_172412.3 → NP_766000.1  glypican-2 isoform 1 precursor

      See identical proteins and their annotated locations for NP_766000.1

      Status: VALIDATED

      Source sequence(s)
      AC159257
      Consensus CDS
      CCDS19799.1
      UniProtKB/Swiss-Prot
      Q8BKV1
      UniProtKB/TrEMBL
      F8WHY9
      Related
      ENSMUSP00000124459.2, ENSMUST00000161827.8
      Conserved Domains (1) summary
      pfam01153
      Location:20 → 559
      Glypican; Glypican

    RNA

    1. NR_184575.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC159257
      Related
      ENSMUST00000161984.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      138271918..138278288 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036165503.1 → XP_036021396.1  glypican-2 isoform X2

      Conserved Domains (1) summary
      pfam01153
      Location:1 → 305
      Glypican

    2. XM_006504624.3 → XP_006504687.1  glypican-2 isoform X2

      Related
      ENSMUST00000159689.8
      Conserved Domains (1) summary
      pfam01153
      Location:1 → 305
      Glypican

    3. XM_036165502.1 → XP_036021395.1  glypican-2 isoform X1

      Conserved Domains (1) summary
      pfam01153
      Location:2 → 424
      Glypican

    4. XM_030254816.2 → XP_030110676.1  glypican-2 isoform X3

      Conserved Domains (1) summary
      pfam01153
      Location:9 → 325
      Glypican
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BKV1.1 GenPept UniProtKB/Swiss-Prot:Q8BKV1

    Gene LinkOut

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