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    Nkx6-1 NK6 homeobox 1 [ Mus musculus (house mouse) ]

    Gene ID: 18096, updated on 27-Nov-2024

    Summary

    Official Symbol
    Nkx6-1provided by MGI
    Official Full Name
    NK6 homeobox 1provided by MGI
    Primary source
    MGI:MGI:1206039
    See related
    Ensembl:ENSMUSG00000035187 AllianceGenome:MGI:1206039
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    NKX6A; Nkx6.1
    Summary
    Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Acts upstream of or within several processes, including enteroendocrine cell differentiation; regulation of axon extension; and regulation of oligodendrocyte differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; future brain; gut; and trachea. Orthologous to human NKX6-1 (NK6 homeobox 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 6.3), stomach adult (RPKM 2.0) and 3 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nkx6-1 in Genome Data Viewer
    Location:
    5 E4- E5; 5 48.84 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (101807050..101812577, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (101659184..101664711, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29982 Neighboring gene predicted gene, 42132 Neighboring gene RIKEN cDNA 9430085M18 gene Neighboring gene STARR-seq mESC enhancer starr_13743 Neighboring gene predicted gene, 42134

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (1) 
    • Targeted (4)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to cytokine stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to peptide hormone stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within central nervous system neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within endocrine pancreas development IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within endocrine pancreas development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of oligodendrocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in neurogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of oligodendrocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within oligodendrocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within pancreatic A cell differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of insulin secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of insulin secretion ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within positive regulation of neuron differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of oligodendrocyte differentiation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of axon extension IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in response to nicotine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within smoothened signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in type B pancreatic cell development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within type B pancreatic cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in type B pancreatic cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in type B pancreatic cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    homeobox protein Nkx-6.1
    Names
    Drosophila NK transcription factor related, gene family 6, locus 1
    NK6 transcription factor related, locus 1
    homeobox protein NK-6 homolog A
    homeodomain transcription factor Nkx6.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_144955.2NP_659204.1  homeobox protein Nkx-6.1

      See identical proteins and their annotated locations for NP_659204.1

      Status: PROVISIONAL

      Source sequence(s)
      AC105976
      Consensus CDS
      CCDS19471.1
      UniProtKB/Swiss-Prot
      B2RQP4, Q99MA9, Q9ERQ7
      Related
      ENSMUSP00000042716.9, ENSMUST00000044125.11
      Conserved Domains (2) summary
      pfam00046
      Location:240293
      Homeobox; Homeobox domain
      pfam11861
      Location:291345
      DUF3381; Domain of unknown function (DUF3381)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      101807050..101812577 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)