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    Prxl2b peroxiredoxin like 2B [ Mus musculus (house mouse) ]

    Gene ID: 66469, updated on 27-Nov-2024

    Summary

    Official Symbol
    Prxl2bprovided by MGI
    Official Full Name
    peroxiredoxin like 2Bprovided by MGI
    Primary source
    MGI:MGI:1913719
    See related
    Ensembl:ENSMUSG00000029059 AllianceGenome:MGI:1913719
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam213b; PM/PGFS; 2810405K02Rik
    Summary
    Enables prostaglandin F synthase activity. Involved in prostaglandin biosynthetic process. Located in cytosol; endoplasmic reticulum; and myelin sheath. Is expressed in thymus primordium. Orthologous to human PRXL2B (peroxiredoxin like 2B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in large intestine adult (RPKM 57.4), small intestine adult (RPKM 50.7) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Prxl2b in Genome Data Viewer
    Location:
    4 E2; 4 85.67 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (154980884..154983522, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (154896430..154899043, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene tetratricopeptide repeat domain 34 Neighboring gene STARR-positive B cell enhancer ABC_E6294 Neighboring gene predicted gene 13112 Neighboring gene STARR-seq mESC enhancer starr_12240 Neighboring gene STARR-positive B cell enhancer ABC_E2734 Neighboring gene membrane metallo-endopeptidase-like 1 Neighboring gene STARR-positive B cell enhancer ABC_E847 Neighboring gene STARR-positive B cell enhancer ABC_E1046 Neighboring gene STARR-seq mESC enhancer starr_12242 Neighboring gene tumor necrosis factor receptor superfamily, member 14 (herpesvirus entry mediator) Neighboring gene STARR-positive B cell enhancer ABC_E9628 Neighboring gene STARR-positive B cell enhancer ABC_E8039 Neighboring gene STARR-positive B cell enhancer ABC_E6295 Neighboring gene STARR-positive B cell enhancer ABC_E2149 Neighboring gene hes family bHLH transcription factor 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (5)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in cellular oxidant detoxification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in prostaglandin biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in prostaglandin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    NOT colocalizes_with cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in myelin sheath IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in myelin sheath ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    prostamide/prostaglandin F synthase
    Names
    family with sequence similarity 213, member B
    prostamide/PG F synthase
    prostamide/PGF synthase
    NP_079858.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025582.4NP_079858.2  prostamide/prostaglandin F synthase

      See identical proteins and their annotated locations for NP_079858.2

      Status: VALIDATED

      Source sequence(s)
      AL607032
      Consensus CDS
      CCDS19016.1
      UniProtKB/Swiss-Prot
      Q9DB60
      Related
      ENSMUSP00000030935.4, ENSMUST00000030935.10
      Conserved Domains (1) summary
      cd02970
      Location:8167
      PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      154980884..154983522 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)