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    SEC14L3 SEC14 like lipid binding 3 [ Homo sapiens (human) ]

    Gene ID: 266629, updated on 27-Nov-2024

    Summary

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    Official Symbol
    SEC14L3provided by HGNC
    Official Full Name
    SEC14 like lipid binding 3provided by HGNC
    Primary source
    HGNC:HGNC:18655
    See related
    Ensembl:ENSG00000100012 MIM:612824; AllianceGenome:HGNC:18655
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TAP2
    Summary
    The protein encoded by this gene is highly similar to the protein encoded by the Saccharomyces cerevisiae SEC14 gene. The SEC14 protein is a phophatidylinositol transfer protein that is essential for biogenesis of Golgi-derived transport vesicles, and thus is required for the export of yeast secretory proteins from the Golgi complex. The specific function of this protein has not yet been determined. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See SEC14L3 in Genome Data Viewer
    Location:
    22q12.2
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (30447661..30472017, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (30911006..30935427, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (30843648..30868004, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372990 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:30831805-30832326 Neighboring gene SLC39A1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18838 Neighboring gene Sharpr-MPRA regulatory region 4237 Neighboring gene uncharacterized LOC105372991 Neighboring gene ReSE screen-validated silencer GRCh37_chr22:30846973-30847332 Neighboring gene uncharacterized LOC107985579 Neighboring gene syndecan 4 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. SEC14L3 plays a tumor-suppressive role in breast cancer through a Wnt/β-catenin-related way. Zhu Q, et al. Exp Cell Res, 2022 Aug 1. PMID 35447102
    2. Characterization of a human Sec14-like protein cDNA SEC14L3 highly homologous to human SPF/TAP. Ye X, et al. Mol Biol Rep, 2004 Mar. PMID 15040456
    3. Genome-wide DNA methylation profiling in nonalcoholic fatty liver reveals predictive aberrant methylation in PRKCE and SEC14L3 promoters. Pan X, et al. Dig Liver Dis, 2022 Apr. PMID 34108094
    4. SEC14L3 knockdown inhibited clear cell renal cell carcinoma proliferation, metastasis and sunitinib resistance through an SEC14L3/RPS3/NFκB positive feedback loop. Jiang Z, et al. J Exp Clin Cancer Res, 2024 Oct 19. PMID 39425205, Free PMC Article
    5. Pulmonary microRNA profiles identify involvement of Creb1 and Sec14l3 in bronchial epithelial changes in allergic asthma. Bartel S, et al. Sci Rep, 2017 Apr 6. PMID 28383034, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SEC14L3 knockdown inhibited clear cell renal cell carcinoma proliferation, metastasis and sunitinib resistance through an SEC14L3/RPS3/NFkappaB positive feedback loop.
      Title: SEC14L3 knockdown inhibited clear cell renal cell carcinoma proliferation, metastasis and sunitinib resistance through an SEC14L3/RPS3/NFκB positive feedback loop.
    2. SEC14L3 plays a tumor-suppressive role in breast cancer through a Wnt/beta-catenin-related way.
      Title: SEC14L3 plays a tumor-suppressive role in breast cancer through a Wnt/β-catenin-related way.
    3. Genome-wide DNA methylation profiling in nonalcoholic fatty liver reveals predictive aberrant methylation in PRKCE and SEC14L3 promoters.
      Title: Genome-wide DNA methylation profiling in nonalcoholic fatty liver reveals predictive aberrant methylation in PRKCE and SEC14L3 promoters.
    4. Creb1/Crtc1-3 and Sec14l3 could be important for early responses of the bronchial epithelium to Th2-stimuli.
      Title: Pulmonary microRNA profiles identify involvement of Creb1 and Sec14l3 in bronchial epithelial changes in allergic asthma.
    5. Here, the authors report that the zebrafish/human phosphatidylinositol transfer protein Sec14l3/SEC14L2 act as GTPase proteins to transduce Wnt signals from Frizzled to phospholipase C (PLC).
      Title: The Sec14-like phosphatidylinositol transfer proteins Sec14l3/SEC14L2 act as GTPase proteins to mediate Wnt/Ca(2+) signaling.
    6. Discusses cloning of rat SEC14-like protein 3 and mentions three human SPF-related genes, known as SEC14-like protein 1, 2 and 3.
      Title: Rat supernatant protein factor-like protein stimulates squalene monooxygenase and is activated by protein kinase A.
    7. we report a human SPF/TAP homology SEC14L3 with 2082 base pairs in length and contains an open reading frame encoding a 400 amino acids protein. Analysis shows that SEC14L3 is mapped to 22q12 and expresses only in the liver
      Title: Characterization of a human Sec14-like protein cDNA SEC14L3 highly homologous to human SPF/TAP.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC119366, MGC119367, MGC119368

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular exosome HDA PubMed 

    General protein information

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    Preferred Names
    SEC14-like protein 3
    Names
    SEC14-like 3
    SEC14p-like protein TAP2
    tocopherol-associated protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027515.2 RefSeqGene

      Range
      5000..17788
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001257378.2 → NP_001244307.1  SEC14-like protein 3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC004832
      Consensus CDS
      CCDS58800.1
      UniProtKB/TrEMBL
      Q495V9
      Related
      ENSP00000385004.1, ENST00000402286.5
      Conserved Domains (1) summary
      smart00516
      Location:2 → 168
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

    2. NM_001257379.2 → NP_001244308.1  SEC14-like protein 3 isoform 3

      See identical proteins and their annotated locations for NP_001244308.1

      Status: REVIEWED

      Source sequence(s)
      AC004832
      Consensus CDS
      CCDS58801.1
      UniProtKB/TrEMBL
      Q495V9
      Related
      ENSP00000383896.1, ENST00000401751.5
      Conserved Domains (1) summary
      smart00516
      Location:17 → 186
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

    3. NM_001257382.2 → NP_001244311.1  SEC14-like protein 3 isoform 3

      See identical proteins and their annotated locations for NP_001244311.1

      Status: REVIEWED

      Source sequence(s)
      AC004832
      Consensus CDS
      CCDS58801.1
      UniProtKB/TrEMBL
      Q495V9
      Conserved Domains (1) summary
      smart00516
      Location:17 → 186
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

    4. NM_001376914.1 → NP_001363843.1  SEC14-like protein 3 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC004832
      Consensus CDS
      CCDS93145.1
      UniProtKB/TrEMBL
      B3KYA6, B5MC44
      Related
      ENSP00000385941.1, ENST00000403066.5
      Conserved Domains (1) summary
      smart00516
      Location:17 → 186
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

    5. NM_174975.5 → NP_777635.1  SEC14-like protein 3 isoform 1

      See identical proteins and their annotated locations for NP_777635.1

      Status: REVIEWED

      Source sequence(s)
      AC004832
      Consensus CDS
      CCDS13877.1
      UniProtKB/Swiss-Prot
      E7EN74, E9PE57, Q495V8, Q495W0, Q495W1, Q9UDX4
      UniProtKB/TrEMBL
      Q6ISB2, Q6XCI7
      Related
      ENSP00000215812.5, ENST00000215812.9
      Conserved Domains (2) summary
      smart00516
      Location:76 → 245
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      smart01100
      Location:13 → 59
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      30447661..30472017 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011530128.3 → XP_011528430.1  SEC14-like protein 3 isoform X1

      UniProtKB/TrEMBL
      B3KYA6
      Conserved Domains (2) summary
      smart00516
      Location:76 → 245
      SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
      smart01100
      Location:13 → 59
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      30911006..30935427 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054325526.1 → XP_054181501.1  SEC14-like protein 3 isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UDX4.1 GenPept UniProtKB/Swiss-Prot:Q9UDX4

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