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    CDK5 cyclin dependent kinase 5 [ Bos taurus (domestic cattle) ]

    Gene ID: 281066, updated on 30-Jan-2025

    Summary

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    Official Symbol
    CDK5provided by VGNC
    Official Full Name
    cyclin dependent kinase 5provided by VGNC
    Primary source
    VGNC:VGNC:27127
    See related
    BGD:BT23839; EnsemblRapid:ENSBTAG00070018139
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Bos taurus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
    Orthologs
    human mouse all
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    Genomic context

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    See CDK5 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_12 current ARS-UCD2.0 (GCF_002263795.3) 4 NC_037331.1 (113630206..113634537, complement)

    Chromosome 4 - NC_037331.1Genomic Context describing neighboring genes Neighboring gene ATP binding cassette subfamily B member 8 Neighboring gene acid sensing ion channel subunit 3 Neighboring gene solute carrier family 4 member 2 Neighboring gene microRNA mir-6525 Neighboring gene Fas activated serine/threonine kinase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_037331.1 Chromosome 4 Reference ARS-UCD2.0 Primary Assembly

    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Dominette sequence data
    • BioProject: PRJNA294306
    • Analysis date: Tue Dec 17 08:57:05 2024

    Bibliography

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    Related articles in PubMed

    1. Brain proline-directed protein kinase is a neurofilament kinase which displays high sequence homology to p34cdc2. Lew J, et al. J Biol Chem, 1992 Dec 25. PMID 1464604
    2. A cdc2-related kinase PSSALRE/cdk5 is homologous with the 30 kDa subunit of tau protein kinase II, a proline-directed protein kinase associated with microtubule. Kobayashi S, et al. FEBS Lett, 1993 Dec 6. PMID 8253190
    3. The cdk5/p35 kinase is essential for neurite outgrowth during neuronal differentiation. Nikolic M, et al. Genes Dev, 1996 Apr 1. PMID 8846918
    4. Early growth response 1 (Egr-1) regulates phosphorylation of microtubule-associated protein tau in mammalian brain. Lu Y, et al. J Biol Chem, 2011 Jun 10. PMID 21489990, Free PMC Article
    5. Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation. Li T, et al. J Biol Chem, 2007 Mar 2. PMID 17202132

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. data indicate that PP1alpha is a downstream target of the NGF/Egr-1/Cdk5 pathway during NGF-induced differentiation of PC12 cells and suggest that PP1 phosphorylation promotes neuronal differentiation
      Title: Phosphorylation of protein phosphatase 1 by cyclin-dependent protein kinase 5 during nerve growth factor-induced PC12 cell differentiation.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC140720

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables cyclin-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in neuron apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in synaptic vesicle transport IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    cyclin-dependent kinase 5
    Names
    PDPK
    TPKII catalytic subunit
    cell division protein kinase 5
    cyclin-dependent-like kinase 5
    proline-directed protein kinase 33 kDa subunit
    serine/threonine-protein kinase PSSALRE
    tau protein kinase II catalytic subunit
    NP_776442.1
    XP_059741373.1
    XP_059741374.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_174017.2 → NP_776442.1  cyclin-dependent kinase 5

      See identical proteins and their annotated locations for NP_776442.1

      Status: PROVISIONAL

      Source sequence(s)
      X82440
      UniProtKB/Swiss-Prot
      Q02399, Q0VCN5, Q6LBE2
      UniProtKB/TrEMBL
      A0AAF6YS17
      Related
      ENSBTAP00070024472.1, ENSBTAT00070041010.1
      Conserved Domains (1) summary
      cd07839
      Location:3 → 286
      STKc_CDK5; Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5

    RefSeqs of Annotated Genomes: GCF_002263795.3-RS_2024_12

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference ARS-UCD2.0 Primary Assembly

    Genomic

    1. NC_037331.1 Reference ARS-UCD2.0 Primary Assembly

      Range
      113630206..113634537 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_059885390.1 → XP_059741373.1  cyclin-dependent kinase 5 isoform X1

      UniProtKB/Swiss-Prot
      Q02399, Q0VCN5, Q6LBE2
      UniProtKB/TrEMBL
      A0AAF6YS17
      Related
      ENSBTAP00070024468.1, ENSBTAT00070041004.1

    2. XM_059885391.1 → XP_059741374.1  cyclin-dependent kinase 5 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q02399.2 GenPept UniProtKB/Swiss-Prot:Q02399

    Gene LinkOut

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