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    Plekha7 pleckstrin homology domain containing A7 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 499249, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Plekha7provided by RGD
    Official Full Name
    pleckstrin homology domain containing A7provided by RGD
    Primary source
    RGD:1598216
    See related
    EnsemblRapid:ENSRNOG00000024602 AllianceGenome:RGD:1598216
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304650
    Summary
    Predicted to enable delta-catenin binding activity. Involved in vasodilation. Predicted to be located in several cellular components, including cell-cell junction; centrosome; and nucleoplasm. Predicted to be part of pore complex. Predicted to be active in zonula adherens. Used to study glomerulosclerosis and hypertension. Orthologous to human PLEKHA7 (pleckstrin homology domain containing A7). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in Kidney (RPKM 92.9), Heart (RPKM 22.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plekha7 in Genome Data Viewer
    Location:
    1q35
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (179798856..179982155, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (170364524..170547843, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (185427600..185493985)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene SRY-box transcription factor 6 Neighboring gene transfer RNA valine (anticodon AAC) 35 Neighboring gene similar to human chromosome 11 open reading frame 58 Neighboring gene uncharacterized LOC120099912 Neighboring gene small nucleolar RNA SNORD14 Neighboring gene phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha Neighboring gene ribosomal protein S13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Mutation of Plekha7 attenuates salt-sensitive hypertension in the rat. Endres BT, et al. Proc Natl Acad Sci U S A, 2014 Sep 2. PMID 25136115, Free PMC Article
    2. A role for ZO-1 and PLEKHA7 in recruiting paracingulin to tight and adherens junctions of epithelial cells. Pulimeno P, et al. J Biol Chem, 2011 May 13. PMID 21454477, Free PMC Article
    3. Anchorage of microtubule minus ends to adherens junctions regulates epithelial cell-cell contacts. Meng W, et al. Cell, 2008 Nov 28. PMID 19041755
    4. Binding between the junctional proteins afadin and PLEKHA7 and implication in the formation of adherens junction in epithelial cells. Kurita S, et al. J Biol Chem, 2013 Oct 11. PMID 23990464, Free PMC Article
    5. A Dock-and-Lock Mechanism Clusters ADAM10 at Cell-Cell Junctions to Promote α-Toxin Cytotoxicity. Shah J, et al. Cell Rep, 2018 Nov 20. PMID 30463011

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZO-1 and PLEKHA7 are paracingulin-interacting proteins that are involved in its recruitment to epithelial tight and adherens junctions, respectively
      Title: A role for ZO-1 and PLEKHA7 in recruiting paracingulin to tight and adherens junctions of epithelial cells.
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables delta-catenin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell-cell adhesion mediated by cadherin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell adhesion mediated by cadherin ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in epithelial cell-cell adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in pore complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in pore complex assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in vasodilation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in zonula adherens maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in zonula adherens maintenance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of pore complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of pore complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in zonula adherens IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in zonula adherens ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family A member 7
    Names
    pleckstrin homology domain containing, family A member 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001432446.1 → NP_001419375.1  pleckstrin homology domain-containing family A member 7 isoform 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6A1V7

    2. NM_001432447.1 → NP_001419376.1  pleckstrin homology domain-containing family A member 7 isoform 2

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6A1V7, A0A8I6GKY3

    3. NM_001432448.1 → NP_001419377.1  pleckstrin homology domain-containing family A member 7 isoform 3

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6A1V7

    4. NM_001432449.1 → NP_001419378.1  pleckstrin homology domain-containing family A member 7 isoform 4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6A229

    5. NM_001432450.1 → NP_001419379.1  pleckstrin homology domain-containing family A member 7 isoform 5

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I5ZXL6, A0A8I6A229

    6. NM_001432451.1 → NP_001419380.1  pleckstrin homology domain-containing family A member 7 isoform 6

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A0G2K6Z8, D3ZRT6

    7. NM_001432452.1 → NP_001419381.1  pleckstrin homology domain-containing family A member 7 isoform 7

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      D3ZRT6

    8. NM_001432453.1 → NP_001419382.1  pleckstrin homology domain-containing family A member 7 isoform 8

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      A0A8I6A229

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      179798856..179982155 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063279498.1 → XP_063135568.1  pleckstrin homology domain-containing family A member 7 isoform X16

      UniProtKB/TrEMBL
      A0A8I6A1V7

    2. XM_039101146.2 → XP_038957074.1  pleckstrin homology domain-containing family A member 7 isoform X6

      UniProtKB/TrEMBL
      A0A8I6A1V7
      Conserved Domains (5) summary
      smart00456
      Location:54 → 85
      WW; Domain with 2 conserved Trp (W) residues
      PHA03247
      Location:861 → 967
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:696 → 852
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:158 → 280
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:10 → 39
      WW; WW domain

    3. XM_039101141.2 → XP_038957069.1  pleckstrin homology domain-containing family A member 7 isoform X4

      UniProtKB/TrEMBL
      A0A8I6A1V7
      Conserved Domains (5) summary
      smart00456
      Location:54 → 85
      WW; Domain with 2 conserved Trp (W) residues
      PHA03247
      Location:874 → 980
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:686 → 865
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:158 → 280
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:10 → 39
      WW; WW domain

    4. XM_063279480.1 → XP_063135550.1  pleckstrin homology domain-containing family A member 7 isoform X11

      UniProtKB/TrEMBL
      A0A8I6A1V7

    5. XM_039101140.2 → XP_038957068.1  pleckstrin homology domain-containing family A member 7 isoform X3

      UniProtKB/TrEMBL
      A0A8I6A1V7
      Conserved Domains (5) summary
      smart00456
      Location:54 → 85
      WW; Domain with 2 conserved Trp (W) residues
      PHA03247
      Location:901 → 1007
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:736 → 892
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:158 → 280
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:10 → 39
      WW; WW domain

    6. XM_039101148.2 → XP_038957076.1  pleckstrin homology domain-containing family A member 7 isoform X9

      UniProtKB/TrEMBL
      A0A8I6A1V7
      Conserved Domains (5) summary
      smart00456
      Location:54 → 85
      WW; Domain with 2 conserved Trp (W) residues
      PHA03247
      Location:901 → 1007
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:736 → 892
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:158 → 280
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:10 → 39
      WW; WW domain

    7. XM_039101137.2 → XP_038957065.1  pleckstrin homology domain-containing family A member 7 isoform X1

      UniProtKB/TrEMBL
      A0A8I6A1V7
      Conserved Domains (5) summary
      smart00456
      Location:54 → 85
      WW; Domain with 2 conserved Trp (W) residues
      PHA03247
      Location:901 → 1007
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:736 → 892
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:158 → 280
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:10 → 39
      WW; WW domain

    8. XM_039101142.2 → XP_038957070.1  pleckstrin homology domain-containing family A member 7 isoform X5

      UniProtKB/TrEMBL
      A0A8I6A1V7
      Conserved Domains (5) summary
      smart00456
      Location:54 → 85
      WW; Domain with 2 conserved Trp (W) residues
      PHA03247
      Location:901 → 1007
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:736 → 892
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:158 → 280
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:10 → 39
      WW; WW domain

    9. XM_063279508.1 → XP_063135578.1  pleckstrin homology domain-containing family A member 7 isoform X19

    10. XM_039101151.2 → XP_038957079.1  pleckstrin homology domain-containing family A member 7 isoform X13

      UniProtKB/TrEMBL
      A0A8I6A1V7
      Related
      ENSRNOP00000074003.3, ENSRNOT00000086681.3
      Conserved Domains (5) summary
      smart00456
      Location:54 → 85
      WW; Domain with 2 conserved Trp (W) residues
      PHA03247
      Location:834 → 940
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:647 → 825
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:158 → 280
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:10 → 39
      WW; WW domain

    11. XM_039101152.2 → XP_038957080.1  pleckstrin homology domain-containing family A member 7 isoform X17

      Conserved Domains (5) summary
      smart00456
      Location:54 → 85
      WW; Domain with 2 conserved Trp (W) residues
      PHA03247
      Location:834 → 940
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:647 → 825
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:158 → 280
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:10 → 39
      WW; WW domain

    12. XM_063279492.1 → XP_063135562.1  pleckstrin homology domain-containing family A member 7 isoform X14

      Related
      ENSRNOP00000094927.2, ENSRNOT00000110407.2

    13. XM_063279505.1 → XP_063135575.1  pleckstrin homology domain-containing family A member 7 isoform X18

      UniProtKB/TrEMBL
      D3ZRT6
      Related
      ENSRNOP00000085633.2, ENSRNOT00000115676.2

    14. XM_039101149.2 → XP_038957077.1  pleckstrin homology domain-containing family A member 7 isoform X10

      UniProtKB/TrEMBL
      D3ZRT6
      Conserved Domains (3) summary
      PHA03247
      Location:850 → 956
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:685 → 841
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:107 → 229
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain

    15. XM_039101147.2 → XP_038957075.1  pleckstrin homology domain-containing family A member 7 isoform X8

      UniProtKB/TrEMBL
      D3ZRT6
      Conserved Domains (3) summary
      PHA03247
      Location:855 → 961
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:690 → 846
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:112 → 234
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain

    16. XM_039101157.2 → XP_038957085.1  pleckstrin homology domain-containing family A member 7 isoform X22

      UniProtKB/TrEMBL
      A0A8I6A7D6, D3ZRT6
      Related
      ENSRNOP00000088208.2, ENSRNOT00000097576.2
      Conserved Domains (3) summary
      PHA03247
      Location:788 → 894
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:601 → 779
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:112 → 234
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain

    17. XM_039101153.2 → XP_038957081.1  pleckstrin homology domain-containing family A member 7 isoform X18

      UniProtKB/TrEMBL
      D3ZRT6
      Conserved Domains (3) summary
      PHA03247
      Location:796 → 902
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:631 → 787
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:53 → 175
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain

    18. XM_039101155.2 → XP_038957083.1  pleckstrin homology domain-containing family A member 7 isoform X20

      UniProtKB/TrEMBL
      D3ZRT6
      Conserved Domains (3) summary
      PHA03247
      Location:665 → 771
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:500 → 656
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cl17171
      Location:15 → 44
      PH-like; Pleckstrin homology-like domain

    19. XM_063279495.1 → XP_063135565.1  pleckstrin homology domain-containing family A member 7 isoform X15

      UniProtKB/TrEMBL
      A0A8I6A1V7
      Related
      ENSRNOP00000059811.4, ENSRNOT00000064706.4

    20. XM_063279471.1 → XP_063135541.1  pleckstrin homology domain-containing family A member 7 isoform X7

      UniProtKB/TrEMBL
      A0A8I6A1V7

    21. XM_039101139.2 → XP_038957067.1  pleckstrin homology domain-containing family A member 7 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A1V7
      Conserved Domains (5) summary
      smart00456
      Location:54 → 85
      WW; Domain with 2 conserved Trp (W) residues
      PHA03247
      Location:901 → 1007
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:736 → 892
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      cd13248
      Location:158 → 280
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain
      pfam00397
      Location:10 → 39
      WW; WW domain

    22. XM_063279520.1 → XP_063135590.1  pleckstrin homology domain-containing family A member 7 isoform X21

      UniProtKB/TrEMBL
      D3ZRT6
      Related
      ENSRNOP00000086270.2, ENSRNOT00000102237.2

    23. XM_039101150.2 → XP_038957078.1  pleckstrin homology domain-containing family A member 7 isoform X12

      UniProtKB/TrEMBL
      A0A8I6A1V7
      Conserved Domains (5) summary
      smart00456
      Location:54 → 85
      WW; Domain with 2 conserved Trp (W) residues
      PHA03247
      Location:901 → 1007
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:736 → 892
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK10263
      Location:910 → 1278
      PRK10263; DNA translocase FtsK; Provisional
      cd13248
      Location:158 → 280
      PH_PEPP1_2_3; Phosphoinositol 3-phosphate binding proteins 1, 2, and 3 pleckstrin homology (PH) domain

    24. XM_063279486.1 → XP_063135556.1  pleckstrin homology domain-containing family A member 7 isoform X12

      UniProtKB/TrEMBL
      A0A8I6A1V7

    25. XM_063279483.1 → XP_063135553.1  pleckstrin homology domain-containing family A member 7 isoform X12

      UniProtKB/TrEMBL
      A0A8I6A1V7

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001144861.1: Suppressed sequence

      Description
      NM_001144861.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from human: PLEKHA7 (GeneID:144100).
    Nucleotide Protein Strain
    Heading Accession and Version

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