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    Gyf Gigyf [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 43842, updated on 9-Dec-2024

    Summary

    Official Symbol
    Gyfprovided by FlyBase
    Official Full Name
    Gigyfprovided by FlyBase
    Primary source
    FLYBASE:FBgn0039936
    Locus tag
    Dmel_CG11148
    See related
    AllianceGenome:FB:FBgn0039936
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG11148; Dmel\CG11148; GIGYF2
    Summary
    Enables mRNA regulatory element binding translation repressor activity. Involved in muscle cell cellular homeostasis; neuron cellular homeostasis; and regulation of autophagy. Part of eukaryotic translation initiation factor 4F complex. Is expressed in organism and ovary. Used to study developmental disorder of mental health. Human ortholog(s) of this gene implicated in Parkinson's disease. Orthologous to several human genes including GIGYF2 (GRB10 interacting GYF protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Gyf in Genome Data Viewer
    Location:
    102E5-102E5; 4-0 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 4 NC_004353.4 (853557..867025, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 4 NC_004353.3 (874342..887651, complement)

    Chromosome 4 - NC_004353.4Genomic Context describing neighboring genes Neighboring gene forkhead domain 102C Neighboring gene pseudo Neighboring gene long non-coding RNA:CR45123 Neighboring gene antisense RNA:CR43425 Neighboring gene unc-13 Neighboring gene antisense RNA:CR44029

    Genomic regions, transcripts, and products

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    mobile_element

    • Loc: c854279-854185 mobile_element_type = transposon:1360{}2818
    • Loc: c857387-857231 mobile_element_type = transposon:INE-1{}5412
    • Loc: c860249-860109 mobile_element_type = transposon:INE-1{}2711

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables mRNA regulatory element binding translation repressor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in muscle cell cellular homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in neuron cellular homeostasis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in regulation of autophagy IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of eukaryotic translation initiation factor 4F complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    gigyf
    Names
    CG11148-PD
    CG11148-PF
    CG11148-PG
    CG11148-PH
    Gyf-PD
    Gyf-PF
    Gyf-PG
    Gyf-PH

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004353.4 Reference assembly

      Range
      853557..867025 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001169357.4NP_001162828.1  gigyf, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162828.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B8A422, D1YSG2, E8NH20, Q7KQM6, Q961G4, Q9V482
      Conserved Domains (2) summary
      cd00072
      Location:566621
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
      pfam12474
      Location:9981112
      PKK; Polo kinase kinase
    2. NM_143693.4NP_651950.3  gigyf, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_651950.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KQM6
      Conserved Domains (2) summary
      cd00072
      Location:559614
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
      pfam12474
      Location:9911105
      PKK; Polo kinase kinase
    3. NM_205878.3NP_995600.2  gigyf, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995600.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q7KQM6
      Conserved Domains (2) summary
      cd00072
      Location:559614
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
      pfam12474
      Location:9911105
      PKK; Polo kinase kinase
    4. NM_001169356.2NP_001162827.1  gigyf, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162827.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      B8A422, D1YSG2, E8NH20, Q7KQM6, Q961G4, Q9V482
      Conserved Domains (2) summary
      cd00072
      Location:566621
      GYF; GYF domain: contains conserved Gly-Tyr-Phe residues; Proline-binding domain in CD2-binding and other proteins. Involved in signaling lymphocyte activity. Also present in other unrelated proteins (mainly unknown) derived from diverse eukaryotic species.
      pfam12474
      Location:9981112
      PKK; Polo kinase kinase