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    Aldh-III Aldehyde dehydrogenase type III [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 45398, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Aldh-IIIprovided by FlyBase
    Official Full Name
    Aldehyde dehydrogenase type IIIprovided by FlyBase
    Primary source
    FLYBASE:FBgn0010548
    Locus tag
    Dmel_CG11140
    See related
    AllianceGenome:FB:FBgn0010548
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    ALDH; ALDH-III; AldhIII; CG11140; CT41571; Dhap; Dmel\CG11140; FALDH; l(2)03610
    Summary
    Predicted to enable aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in cellular aldehyde metabolic process. Predicted to be active in cytoplasm. Is expressed in several structures, including adult brain; adult head; adult heart; epidermis; and gut section. Human ortholog(s) of this gene implicated in Sjogren-Larsson syndrome and arteriosclerosis. Orthologous to several human genes including ALDH3B1 (aldehyde dehydrogenase 3 family member B1) and ALDH3B2 (aldehyde dehydrogenase 3 family member B2). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Aldh-III in Genome Data Viewer
    Location:
    43C4-43C4; 2-56 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (7466879..7477162, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (3354384..3364667, complement)

    Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene p47 Neighboring gene wech Neighboring gene antisense RNA:CR43723 Neighboring gene Corepressor of Pangolin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A transposable element insertion confers xenobiotic resistance in Drosophila. Mateo L, et al. PLoS Genet, 2014 Aug. PMID 25122208, Free PMC Article
    2. Genetic mapping of the p47 (L.3.2) mutation in Drosophilamelanogaster. Cordes CN, et al. MicroPubl Biol, 2023. PMID 37799208, Free PMC Article
    3. Trade-off between toxicity and signal detection orchestrated by frequency- and density-dependent genes. Arthaud L, et al. PLoS One, 2011. PMID 21625551, Free PMC Article
    4. Proteomic analysis reveals oxidative stress-induced activation of Hippo signaling in thiamethoxam-exposed Drosophila. Li X, et al. Chemosphere, 2023 Oct. PMID 37437626
    5. Population genomics of transposable elements in Drosophila. Barrón MG, et al. Annu Rev Genet, 2014. PMID 25292358

    See all (65) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables aldehyde dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables aldehyde dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in aldehyde metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in aldehyde metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in aldehyde metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial outer membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    aldehyde dehydrogenase type III
    Names
    Aldh-III-PE
    Aldh-III-PI
    Aldh-III-PK
    Aldh-III-PL
    Aldh-III-PM
    Aldh-III-PN
    Aldh-III-PO
    Aldh-III-PP
    Aldh-III-PQ
    Aldh-III-PR
    Aldh-III-PS
    Aldh-III-PU
    CG11140-PE
    CG11140-PI
    CG11140-PK
    CG11140-PL
    CG11140-PM
    CG11140-PN
    CG11140-PO
    CG11140-PP
    CG11140-PQ
    CG11140-PR
    CG11140-PS
    CG11140-PU
    fatty aldehyde dehydrogenase
    NP_001260772.1
    NP_001260773.1
    NP_001260775.1
    NP_610285.5
    NP_724560.1
    NP_724561.2
    NP_724562.2
    NP_724563.2
    NP_724564.2
    NP_724565.3
    NP_724566.3
    NP_995772.1

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033778.4 Reference assembly

      Range
      7466879..7477162 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165531.3 → NP_724565.3  aldehyde dehydrogenase type III, isoform O [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724565.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6Z4, Q8IGH3
      Conserved Domains (1) summary
      cd07132
      Location:71 → 514
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

    2. NM_165528.3 → NP_724562.2  aldehyde dehydrogenase type III, isoform Q [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724562.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4DHC8, Q8IGH3
      Conserved Domains (1) summary
      cd07132
      Location:72 → 515
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

    3. NM_165532.3 → NP_724566.3  aldehyde dehydrogenase type III, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724566.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A4UZ69, E3CTS3
      Conserved Domains (1) summary
      cd07132
      Location:71 → 514
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

    4. NM_136441.4 → NP_610285.5  aldehyde dehydrogenase type III, isoform P [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_610285.5

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0C4FEI5, E3CTS3, F0JAM9
      Conserved Domains (1) summary
      cd07132
      Location:72 → 515
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

    5. NM_165529.3 → NP_724563.2  aldehyde dehydrogenase type III, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724563.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E3CTS3, Q0E9G6, Q7JR61
      Conserved Domains (1) summary
      cd07132
      Location:6 → 449
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

    6. NM_206050.3 → NP_995772.1  aldehyde dehydrogenase type III, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_995772.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A1Z6Z3, Q8IGH3
      Conserved Domains (1) summary
      cd07132
      Location:6 → 449
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

    7. NM_001273846.1 → NP_001260775.1  aldehyde dehydrogenase type III, isoform U [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260775.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KF99, Q8IGH3
      Conserved Domains (1) summary
      cd07132
      Location:6 → 449
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

    8. NM_001273843.1 → NP_001260772.1  aldehyde dehydrogenase type III, isoform R [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260772.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEE1, E3CTS3
      Conserved Domains (1) summary
      cd07132
      Location:6 → 449
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

    9. NM_165527.3 → NP_724561.2  aldehyde dehydrogenase type III, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724561.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E3CTS3, Q0E9G6, Q7JR61
      Conserved Domains (1) summary
      cd07132
      Location:6 → 449
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

    10. NM_001273844.1 → NP_001260773.1  aldehyde dehydrogenase type III, isoform S [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260773.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KEL0, Q8IGH3
      Conserved Domains (1) summary
      cd07132
      Location:6 → 449
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

    11. NM_165530.3 → NP_724564.2  aldehyde dehydrogenase type III, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724564.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      E3CTS3, Q0E9G6, Q7JR61
      Conserved Domains (1) summary
      cd07132
      Location:6 → 449
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins

    12. NM_165526.3 → NP_724560.1  aldehyde dehydrogenase type III, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_724560.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      E3CTS3, Q0E9G6, Q7JR61
      Related
      FBpp0088066
      Conserved Domains (1) summary
      cd07132
      Location:6 → 449
      ALDH_F3AB; Aldehyde dehydrogenase family 3 members A1, A2, and B1 and related proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4KEE1 A0A0B4KEE1
    A0A0B4KEL0 A0A0B4KEL0
    A0A0B4KF99 A0A0B4KF99
    A0A0C4DHC8 A0A0C4DHC8
    A0A0C4FEI5 A0A0C4FEI5
    A1Z6Z3 A1Z6Z3
    A1Z6Z4 A1Z6Z4
    A4UZ69 A4UZ69
    Q7JR61 Q7JR61
    Q8IGH3 Q8IGH3
    Q8T0K8 Q8T0K8

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