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    dpr3 defective proboscis extension response 3 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 3346208, updated on 9-Dec-2024

    Summary

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    Official Symbol
    dpr3provided by FlyBase
    Official Full Name
    defective proboscis extension response 3provided by FlyBase
    Primary source
    FLYBASE:FBgn0053516
    Locus tag
    Dmel_CG33516
    See related
    AllianceGenome:FB:FBgn0053516
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15379; CG15380; CG15381; CG33516; CRACM2; CT35425; Dmel\CG33516; Dpr-3; Dpr3
    Summary
    Involved in store-operated calcium entry and synapse organization. Predicted to be located in plasma membrane. Predicted to be active in neuron projection membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See dpr3 in Genome Data Viewer
    Location:
    22C1-22C3; 2-4 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (2058790..2109878, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (2058790..2109878, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene Kinetochore and EB1 associated basic protein Neighboring gene Odorant receptor 22c Neighboring gene long non-coding RNA:CR44808 Neighboring gene long non-coding RNA:CR44055 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Glycogen phosphorylase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry. Vig M, et al. Science, 2006 May 26. PMID 16645049, Free PMC Article
    2. Modular transcriptional programs separately define axon and dendrite connectivity. Kurmangaliyev YZ, et al. Elife, 2019 Nov 5. PMID 31687928, Free PMC Article
    3. Combinations of DIPs and Dprs control organization of olfactory receptor neuron terminals in Drosophila. Barish S, et al. PLoS Genet, 2018 Aug. PMID 30102700, Free PMC Article
    4. Defective proboscis extension response (DPR), a member of the Ig superfamily required for the gustatory response to salt. Nakamura M, et al. J Neurosci, 2002 May 1. PMID 11978823, Free PMC Article
    5. Neural immunoglobulin superfamily interaction networks. Zinn K, et al. Curr Opin Neurobiol, 2017 Aug. PMID 28558267, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    mobile_element

    • Loc: c2109522-2100430 mobile_element_type = transposon:roo{}2620

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in sensory perception of chemical stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in store-operated calcium entry IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in synapse organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in synapse organization IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in neuron projection membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    defective proboscis extension response 3
    Names
    CG33516-PB
    CG33516-PC
    CG33516-PD
    CRAC modulator 2
    dpr3-PB
    dpr3-PC
    dpr3-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      2058790..2109878 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001272973.1 → NP_001259902.1  defective proboscis extension response 3, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259902.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q59E13
      Conserved Domains (2) summary
      smart00410
      Location:243 → 329
      IG_like; Immunoglobulin like
      cl11960
      Location:243 → 330
      Ig; Immunoglobulin domain

    2. NM_001014459.2 → NP_001014459.2  defective proboscis extension response 3, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001014459.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q59E13
      Conserved Domains (2) summary
      smart00410
      Location:243 → 329
      IG_like; Immunoglobulin like
      cl11960
      Location:243 → 330
      Ig; Immunoglobulin domain

    3. NM_001272972.1 → NP_001259901.1  defective proboscis extension response 3, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259901.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q59E13
      Conserved Domains (2) summary
      smart00410
      Location:243 → 329
      IG_like; Immunoglobulin like
      cl11960
      Location:243 → 330
      Ig; Immunoglobulin domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q59E13 Q59E13

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