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    ine inebriated [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 33659, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ineprovided by FlyBase
    Official Full Name
    inebriatedprovided by FlyBase
    Primary source
    FLYBASE:FBgn0011603
    Locus tag
    Dmel_CG15444
    See related
    AllianceGenome:FB:FBgn0011603
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG15444; CG15444d; Dmel\CG15444; DMINE; ine/rosA; rosA
    Summary
    Enables osmosensor activity. Involved in several processes, including multicellular organismal-level water homeostasis; perineurial glial growth; and transmission of nerve impulse. Located in basolateral plasma membrane. Is expressed in several structures, including Malpighian tubule; embryonic/larval midgut primordium; gut section; head; and ventral nerve cord. [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See ine in Genome Data Viewer
    Location:
    24F4-24F4; 2-12 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (4468000..4477022, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (4468000..4477022, complement)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Parkin Interacting Substrate Neighboring gene FIG4 phosphoinositide 5-phosphatase Neighboring gene dumpy Neighboring gene long non-coding RNA:CR43716 Neighboring gene Heterochromatin protein 6

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A neurotransmitter transporter encoded by the Drosophila inebriated gene. Soehnge H, et al. Proc Natl Acad Sci U S A, 1996 Nov 12. PMID 8917579, Free PMC Article
    2. The putative Na⁺/Cl⁻-dependent neurotransmitter/osmolyte transporter inebriated in the Drosophila hindgut is essential for the maintenance of systemic water homeostasis. Luan Z, et al. Sci Rep, 2015 Jan 23. PMID 25613130, Free PMC Article
    3. Location and functions of Inebriated in the Drosophila eye. Borycz J, et al. Biol Open, 2018 Jul 23. PMID 30037884, Free PMC Article
    4. The transporter-like protein inebriated mediates hyperosmotic stimuli through intracellular signaling. Chiu C, et al. J Exp Biol, 2000 Dec. PMID 11060215
    5. In vivo properties of the Drosophila inebriated-encoded neurotransmitter transporter. Huang Y, et al. J Neurosci, 2002 Mar 1. PMID 11880499, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. two protein isoforms encoded by the inebriated (ine) gene perform osmolyte transport within the Malpighian tubule and hindgut
      Title: The Drosophila inebriated-encoded neurotransmitter/osmolyte transporter: dual roles in the control of neuronal excitability and the osmotic stress response.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables amino acid:sodium symporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables neurotransmitter:sodium symporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables neurotransmitter:sodium symporter activity ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    enables neurotransmitter:sodium symporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables osmosensor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables osmosensor activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in glial cell growth IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in glial cell growth IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in glycine import across plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in multicellular organismal-level water homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neurotransmitter transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neurotransmitter transport ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in perineurial glial growth IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sodium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transmission of nerve impulse IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in transmission of nerve impulse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    inebriated
    Names
    CG15444-PA
    CG15444-PB
    CG15444-PC
    CG15444-PE
    CG15444-PF
    ine-PA
    ine-PB
    ine-PC
    ine-PE
    ine-PF

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      4468000..4477022 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_175958.3 → NP_787972.1  inebriated, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_787972.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V056, O02003, Q94917, Q9VR07
      UniProtKB/TrEMBL
      E1JHT2
      Related
      FBpp0077138
      Conserved Domains (1) summary
      cl00456
      Location:337 → 876
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    2. NM_057664.6 → NP_477012.1  inebriated, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477012.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V056, O02003, Q94917, Q9VR07
      UniProtKB/TrEMBL
      E1JHT2
      Related
      FBpp0077136
      Conserved Domains (1) summary
      cl00456
      Location:337 → 876
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    3. NM_057665.5 → NP_477013.1  inebriated, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477013.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      C8VV47
      Related
      FBpp0077137
      Conserved Domains (1) summary
      cl00456
      Location:52 → 591
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    4. NM_001169400.2 → NP_001162871.1  inebriated, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001162871.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V056, O02003, Q94917, Q9VR07
      UniProtKB/TrEMBL
      E1JHT2
      Conserved Domains (1) summary
      cl00456
      Location:337 → 876
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain

    5. NM_175959.3 → NP_787973.1  inebriated, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_787973.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A4V056, O02003, Q94917, Q9VR07
      UniProtKB/TrEMBL
      E1JHT2
      Related
      FBpp0290621
      Conserved Domains (1) summary
      cl00456
      Location:337 → 876
      SLC5-6-like_sbd; Solute carrier families 5 and 6-like; solute binding domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    E1JHT2 E1JHT2
    Q9VR07.1 Q9VR07

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