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    Ttc30 Tetratricopeptide repeat domain 30 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34702, updated on 17-Dec-2024

    Summary

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    Official Symbol
    Ttc30provided by FlyBase
    Official Full Name
    Tetratricopeptide repeat domain 30provided by FlyBase
    Primary source
    FLYBASE:FBgn0032470
    Locus tag
    Dmel_CG5142
    See related
    AllianceGenome:FB:FBgn0032470
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5142; Dmel\CG5142; TTC30
    Summary
    Predicted to enable intraciliary transport particle B binding activity. Involved in cilium assembly. Predicted to be located in cilium. Predicted to be part of intraciliary transport particle B. Predicted to be active in axonemal microtubule. Is expressed in chordotonal neurons; eo neurons; and larval antenno-maxillary sensory complex. Orthologous to human IFT70A (intraflagellar transport 70A) and IFT70B (intraflagellar transport 70B). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Ttc30 in Genome Data Viewer
    Location:
    34A5-34A5; 2-47 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13106807..13109468)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13106807..13109468)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45447 Neighboring gene long non-coding RNA:CR45461 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Evolution of modular intraflagellar transport from a coatomer-like progenitor. van Dam TJ, et al. Proc Natl Acad Sci U S A, 2013 Apr 23. PMID 23569277, Free PMC Article
    2. Genomic Diversity Illuminates the Environmental Adaptation of Drosophila suzukii. Feng S, et al. Genome Biol Evol, 2024 Sep 3. PMID 39235033, Free PMC Article
    3. Identification of novel regulatory factor X (RFX) target genes by comparative genomics in Drosophila species. Laurençon A, et al. Genome Biol, 2007. PMID 17875208, Free PMC Article
    4. Decoding cilia function: defining specialized genes required for compartmentalized cilia biogenesis. Avidor-Reiss T, et al. Cell, 2004 May 14. PMID 15137945
    5. Circulating glucose levels inversely correlate with Drosophila larval feeding through insulin signaling and SLC5A11. Ugrankar R, et al. Commun Biol, 2018. PMID 30271990, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables intraciliary transport particle B binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cilium assembly IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in cilium assembly ISM
    Inferred from Sequence Model
    more info
    		 PubMed 
    involved_in intraciliary transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intraciliary transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein polyglutamylation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in axonemal microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in axonemal microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cilium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of intraciliary transport particle B IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of intraciliary transport particle B ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    tetratricopeptide repeat domain 30
    Names
    CG5142-PC
    CG5142-PD
    Ttc30-PC
    Ttc30-PD

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13106807..13109468
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001273501.1 → NP_001260430.1  tetratricopeptide repeat domain 30, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001260430.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4V562, Q4V594, Q9VK41
      UniProtKB/TrEMBL
      M9PDD5, V5RBK1
      Conserved Domains (3) summary
      sd00006
      Location:46 → 71
      TPR; TPR repeat [structural motif]
      pfam07719
      Location:45 → 75
      TPR_2; Tetratricopeptide repeat
      pfam13414
      Location:143 → 205
      TPR_11; TPR repeat

    2. NM_001103685.3 → NP_001097155.2  tetratricopeptide repeat domain 30, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097155.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q4V562, Q4V594, Q9VK41
      UniProtKB/TrEMBL
      M9PDD5, V5RBK1
      Conserved Domains (3) summary
      sd00006
      Location:46 → 71
      TPR; TPR repeat [structural motif]
      pfam07719
      Location:45 → 75
      TPR_2; Tetratricopeptide repeat
      pfam13414
      Location:143 → 205
      TPR_11; TPR repeat
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    M9PDD5 M9PDD5
    Q9VK41.3 Q9VK41

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