U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    PIK3IP1 phosphoinositide-3-kinase interacting protein 1 [ Homo sapiens (human) ]

    Gene ID: 113791, updated on 9-Dec-2024

    Summary

    Official Symbol
    PIK3IP1provided by HGNC
    Official Full Name
    phosphoinositide-3-kinase interacting protein 1provided by HGNC
    Primary source
    HGNC:HGNC:24942
    See related
    Ensembl:ENSG00000100100 MIM:619158; AllianceGenome:HGNC:24942
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HGFL; TrIP; hHGFL(S)
    Summary
    Enables phosphatidylinositol 3-kinase inhibitor activity. Involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in lymph node (RPKM 60.4), appendix (RPKM 38.3) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PIK3IP1 in Genome Data Viewer
    Location:
    22q12.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 22 NC_000022.11 (31281593..31292534, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 22 NC_060946.1 (31745576..31756513, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 22 NC_000022.10 (31677579..31688520, complement)

    Chromosome 22 - NC_000022.11Genomic Context describing neighboring genes Neighboring gene LIM domain kinase 2 Neighboring gene RNA, U6 small nuclear 1128, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18851 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:31643479-31644369 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:31644370-31645259 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr22:31672194-31672774 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr22:31674451-31674951 Neighboring gene protein phosphatase 1 regulatory inhibitor subunit 14B pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18852 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18853 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13625 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13626 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18854 Neighboring gene uncharacterized LOC105372997 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18855 Neighboring gene RNA, 5S ribosomal pseudogene 496

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC17330

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol 3-kinase inhibitor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables phosphatidylinositol 3-kinase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    phosphoinositide-3-kinase-interacting protein 1
    Names
    PI3K-interacting protein 1
    kringle domain-containing protein HGFL
    transmembrane inhibitor of PI3K

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001135911.1NP_001129383.1  phosphoinositide-3-kinase-interacting protein 1 isoform 2 precursor

      See identical proteins and their annotated locations for NP_001129383.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) is missing the penultimate coding exon compared to transcript variant 1. This results in a frame-shift, early translation termination and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC002073, AK299397, AW005175, DC412134
      Consensus CDS
      CCDS46690.1
      UniProtKB/Swiss-Prot
      Q96FE7
      Related
      ENSP00000415608.1, ENST00000441972.5
      Conserved Domains (1) summary
      cd00108
      Location:22102
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...
    2. NM_052880.5NP_443112.2  phosphoinositide-3-kinase-interacting protein 1 isoform 1 precursor

      See identical proteins and their annotated locations for NP_443112.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AC002073, AW005175, DC412134
      Consensus CDS
      CCDS13893.1
      UniProtKB/Swiss-Prot
      B4DRR9, D1MEI0, O00318, Q49A94, Q86YW2, Q8NCJ9, Q96FE7
      UniProtKB/TrEMBL
      B4DV97
      Related
      ENSP00000215912.4, ENST00000215912.10
      Conserved Domains (1) summary
      cd00108
      Location:22102
      KR; Kringle domain; Kringle domains are believed to play a role in binding mediators, such as peptides, other proteins, membranes, or phospholipids. They are autonomous structural domains, found in a varying number of copies, in blood clotting and ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000022.11 Reference GRCh38.p14 Primary Assembly

      Range
      31281593..31292534 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060946.1 Alternate T2T-CHM13v2.0

      Range
      31745576..31756513 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)