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    CG5068 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39032, updated on 9-Dec-2024

    Summary

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    Official Symbol
    CG5068provided by FlyBase
    Official Full Name
    uncharacterized proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0035951
    Locus tag
    Dmel_CG5068
    See related
    AllianceGenome:FB:FBgn0035951
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    Dmel\CG5068
    Summary
    Enables serine hydrolase activity. Is expressed in adult head and organism. Orthologous to human PPME1 (protein phosphatase methylesterase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See CG5068 in Genome Data Viewer
    Location:
    66F1-66F1; 3-28 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8986710..8989135)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8979810..8982235)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Signal recognition particle 68 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Galactokinase Neighboring gene uncharacterized protein Neighboring gene smaug Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Acute and long-term outcomes in a Drosophila melanogaster model of classic galactosemia occur independently of galactose-1-phosphate accumulation. Daenzer JM, et al. Dis Model Mech, 2016 Nov 1. PMID 27562100, Free PMC Article
    2. Systematic determination of patterns of gene expression during Drosophila embryogenesis. Tomancak P, et al. Genome Biol, 2002. PMID 12537577, Free PMC Article
    3. Ancient Male Recombination Shaped Genetic Diversity of Neo-Y Chromosome in Drosophila albomicans. Satomura K, et al. Mol Biol Evol, 2016 Feb. PMID 26494844
    4. A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster. Kumar K, et al. Biochemistry, 2021 Apr 27. PMID 33827210, Free PMC Article
    5. In vivo profiling of the Zucchini proximal proteome in the Drosophila ovary. Nguyen TTM, et al. Development, 2023 Feb 15. PMID 36762624

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables protein C-terminal methylesterase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein methylesterase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables serine hydrolase activity HDA PubMed 
    Process Evidence Code Pubs
    involved_in protein demethylation IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    uncharacterized protein
    Names
    CG5068-PA
    CG5068-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      8986710..8989135
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001274680.1 → NP_001261609.1  uncharacterized protein Dmel_CG5068, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001261609.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95R98, Q9VSS6
      Conserved Domains (2) summary
      COG0596
      Location:70 → 204
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam12695
      Location:73 → 161
      Abhydrolase_5; Alpha/beta hydrolase family

    2. NM_140020.3 → NP_648277.3  uncharacterized protein Dmel_CG5068, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648277.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95R98, Q9VSS6
      Related
      FBpp0076246
      Conserved Domains (2) summary
      COG0596
      Location:70 → 204
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam12695
      Location:73 → 161
      Abhydrolase_5; Alpha/beta hydrolase family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q95R98 Q95R98

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