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    Inka1 inka box actin regulator 1 [ Mus musculus (house mouse) ]

    Gene ID: 68176, updated on 9-Dec-2024

    Summary

    Official Symbol
    Inka1provided by MGI
    Official Full Name
    inka box actin regulator 1provided by MGI
    Primary source
    MGI:MGI:1915426
    See related
    Ensembl:ENSMUSG00000042106 AllianceGenome:MGI:1915426
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam212a; 6230427J02Rik
    Summary
    Predicted to enable protein kinase binding activity and protein serine/threonine kinase inhibitor activity. Acts upstream of or within neural tube development. Predicted to be located in cytoplasm. Predicted to be active in nucleus. Is expressed in several structures, including blood island; brain; branchial arch; embryo mesenchyme; and heart. Orthologous to human INKA1 (inka box actin regulator 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 26.2), liver E14.5 (RPKM 18.5) and 24 other tissues See more
    Orthologs
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    Genomic context

    See Inka1 in Genome Data Viewer
    Location:
    9 F1; 9 59.07 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107861422..107863078, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (107984223..107985916, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene TRAF-interacting protein Neighboring gene STARR-positive B cell enhancer ABC_E3858 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:107878063-107878250 Neighboring gene STARR-positive B cell enhancer ABC_E2913 Neighboring gene ubiquitin-like modifier activating enzyme 7 Neighboring gene RIKEN cDNA 4930535L15 gene Neighboring gene cadherin-related family member 4 Neighboring gene STARR-positive B cell enhancer ABC_E61 Neighboring gene inositol hexaphosphate kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E2305

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine kinase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine/threonine kinase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within neural tube development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    PAK4-inhibitor INKA1
    Names
    MInca
    family with sequence similarity 212, member A
    inca
    induced in neural crest by AP2-alpha protein homolog
    protein FAM212A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_026597.4NP_080873.2  PAK4-inhibitor INKA1

      See identical proteins and their annotated locations for NP_080873.2

      Status: VALIDATED

      Source sequence(s)
      AL731808
      Consensus CDS
      CCDS52919.1
      UniProtKB/Swiss-Prot
      Q08EG3, Q80WB2, Q8BPE9, Q9CX62
      Related
      ENSMUSP00000040433.5, ENSMUST00000048568.6
      Conserved Domains (1) summary
      pfam15342
      Location:162201
      FAM212; FAM212 family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      107861422..107863078 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)