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    PNKP Polynucleotide kinase 3'-phosphatase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40994, updated on 9-Dec-2024

    Summary

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    Official Symbol
    PNKPprovided by FlyBase
    Official Full Name
    Polynucleotide kinase 3'-phosphataseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0037578
    Locus tag
    Dmel_CG9601
    See related
    AllianceGenome:FB:FBgn0037578
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    28573184; CG9601; Dmel\CG9601
    Summary
    Predicted to enable ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity; double-stranded DNA binding activity; and polynucleotide 3'-phosphatase activity. Predicted to be involved in DNA repair. Predicted to be located in nucleus. Used to study ataxia-oculomotor apraxia type 4. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2B2; ataxia-oculomotor apraxia type 4; and microcephaly, seizures, and developmental delay. Orthologous to human PNKP (polynucleotide kinase 3'-phosphatase). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See PNKP in Genome Data Viewer
    Location:
    84F13-84F13; 3-48 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (8341661..8343516, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (4167383..4169238, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Pox meso Neighboring gene uncharacterized protein Neighboring gene Cytochrome c oxidase subunit 7A Neighboring gene ADP ribosylation factor-like 2 Neighboring gene Cytochrome c oxidase subunit 7A-like Neighboring gene Dipeptidyl aminopeptidase III

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntington's disease. Chakraborty A, et al. Proc Natl Acad Sci U S A, 2024 Sep 24. PMID 39298485,
    2. Deficiency in classical nonhomologous end-joining-mediated repair of transcribed genes is linked to SCA3 pathogenesis. Chakraborty A, et al. Proc Natl Acad Sci U S A, 2020 Apr 7. PMID 32205441, Free PMC Article
    3. Ataxia-associated DNA repair genes protect the Drosophila mushroom body and locomotor function against glutamate signaling-associated damage. Eidhof I, et al. Front Neural Circuits, 2023. PMID 37476399, Free PMC Article
    4. Arl2- and Msps-dependent microtubule growth governs asymmetric division. Chen K, et al. J Cell Biol, 2016 Mar 14. PMID 26953351, Free PMC Article
    5. Morphologically different hydroxyapatite nanoparticles exert differential genotoxic effects in Drosophila. Güneş M, et al. Sci Total Environ, 2023 Dec 15. PMID 37633389

    See all (39) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntington's disease.
      Title: Fructose-2,6-bisphosphate restores DNA repair activity of PNKP and ameliorates neurodegenerative symptoms in Huntington's disease.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables polynucleotide 3'-phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables polynucleotide 3'-phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    polynucleotide kinase 3'-phosphatase
    Names
    CG9601-PA
    PNKP ortholog
    PNKP-PA
    NP_649792.3

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      8341661..8343516 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_141535.4 → NP_649792.3  polynucleotide kinase 3'-phosphatase [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_649792.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8MZ20, Q9VHS0
      Related
      FBpp0081343
      Conserved Domains (4) summary
      cd01427
      Location:170 → 288
      HAD_like; Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others, ...
      TIGR01663
      Location:9 → 522
      PNK-3'Pase; polynucleotide 5'-kinase 3'-phosphatase
      cd00060
      Location:26 → 115
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cl17190
      Location:367 → 440
      NK; Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8MZ20 Q8MZ20
    Q9VHS0 Q9VHS0

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