U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    Mocs1 Molybdenum cofactor synthesis 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39238, updated on 9-Dec-2024

    Summary

    Official Symbol
    Mocs1provided by FlyBase
    Official Full Name
    Molybdenum cofactor synthesis 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0263241
    Locus tag
    Dmel_CG33048
    See related
    AllianceGenome:FB:FBgn0263241
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG33048; CG7858; Dmel\CG33048; lxd; Mocs1A; MOCS1A; Mocs1A-B; Mocs1B; MOCS1B; mocsI; MocsI; MOCSI; Mosc1A+Mosc1B; pfs
    Summary
    Predicted to enable GTP 3',8'-cyclase activity and cyclic pyranopterin monophosphate synthase activity. Involved in inter-male aggressive behavior. Is expressed in several structures, including adult brain; embryonic/larval mushroom body; ganglia; imaginal disc; and synaptic neuropil domain. Human ortholog(s) of this gene implicated in molybdenum cofactor deficiency type A. Orthologous to human MOCS1 (molybdenum cofactor synthesis 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Mocs1 in Genome Data Viewer
    Location:
    68A4-68A4; 3-34 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11070526..11073348)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11063626..11066448)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Suppressor of Under-Replication Neighboring gene uncharacterized protein Neighboring gene Prefoldin 2 Neighboring gene Nucleolar complex protein 1 Neighboring gene JIL-1 kinase

    Genomic regions, transcripts, and products

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables 4 iron, 4 sulfur cluster binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTP 3',8'-cyclase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP 3',8'-cyclase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cyclic pyranopterin monophosphate synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cyclic pyranopterin monophosphate synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Mo-molybdopterin cofactor biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Mo-molybdopterin cofactor biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Mo-molybdopterin cofactor biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in inter-male aggressive behavior IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in iron-sulfur cluster assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    molybdenum cofactor synthesis 1
    Names
    CG33048-PA
    CG33048-PC
    Mocs1-PA
    Mocs1-PC
    low xanthine dehydrogenase
    molybdenum cofactor synthesis 1 ortholog
    peacefulness
    NP_788494.1
    NP_788495.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      11070526..11073348
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_176316.2NP_788494.1  molybdenum cofactor synthesis 1, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788494.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IQF1, Q9NIG3, Q9NIG4, Q9VTE4
      Related
      FBpp0075935
      Conserved Domains (4) summary
      cd01335
      Location:74249
      Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
      PRK00164
      Location:59366
      moaA; molybdenum cofactor biosynthesis protein A; Reviewed
      PRK09364
      Location:399555
      moaC; molybdenum cofactor biosynthesis protein MoaC; Provisional
      pfam06463
      Location:240367
      Mob_synth_C; Molybdenum Cofactor Synthesis C
    2. NM_176317.2NP_788495.1  molybdenum cofactor synthesis 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788495.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IQF1
      Related
      FBpp0075934
      Conserved Domains (3) summary
      cd01335
      Location:74249
      Radical_SAM; Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster. ...
      PLN02951
      Location:43385
      PLN02951; Molybderin biosynthesis protein CNX2
      pfam06463
      Location:240367
      Mob_synth_C; Molybdenum Cofactor Synthesis C