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    Hip1 Huntingtin interacting protein 1 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 39450, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Hip1provided by FlyBase
    Official Full Name
    Huntingtin interacting protein 1provided by FlyBase
    Primary source
    FLYBASE:FBgn0036309
    Locus tag
    Dmel_CG10971
    See related
    AllianceGenome:FB:FBgn0036309
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10971; Dmel\CG10971; hip1; Hip1R
    Summary
    Predicted to enable several functions, including anion binding activity; clathrin adaptor activity; and clathrin light chain binding activity. Predicted to be involved in actin filament organization; clathrin coat assembly; and endocytosis. Predicted to be active in clathrin-coated vesicle and cortical actin cytoskeleton. Is expressed in adult head. Orthologous to human HIP1 (huntingtin interacting protein 1) and HIP1R (huntingtin interacting protein 1 related). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See Hip1 in Genome Data Viewer
    Location:
    69E2-69E2; 3-39 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12768432..12773573, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12761532..12766673, complement)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Kinesin light chain Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Vacuolar protein sorting 13D Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Huntingtin interacting protein 1 can regulate neurogenesis in Drosophila. Moores JN, et al. Eur J Neurosci, 2008 Aug. PMID 18702731
    2. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Turcot V, et al. Nat Genet, 2018 Jan. PMID 29273807, Free PMC Article
    3. Functionally Validating Evolutionary Conserved Risk Genes for Parkinson's Disease in Drosophila melanogaster. Baisgaard AE, et al. Insects, 2023 Feb 9. PMID 36835737, Free PMC Article
    4. Excess Rab4 rescues synaptic and behavioral dysfunction caused by defective HTT-Rab4 axonal transport in Huntington's disease. White JA 2nd, et al. Acta Neuropathol Commun, 2020 Jul 1. PMID 32611447, Free PMC Article
    5. HTT (huntingtin) and RAB7 co-migrate retrogradely on a signaling LAMP1-containing late endosome during axonal injury. Krzystek TJ, et al. Autophagy, 2023 Apr. PMID 36048753, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables clathrin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables clathrin light chain binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,4-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphatidylinositol-3,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phospholipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in clathrin coat assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in clathrin-coated vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cortical actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    huntingtin interacting protein 1
    Names
    CG10971-PA
    CG10971-PB
    Hip1-PA
    Hip1-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      12768432..12773573 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_140340.2 → NP_648597.2  huntingtin interacting protein 1, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_648597.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5A7B5, Q8MQJ8, Q9VU10
      Related
      FBpp0075680
      Conserved Domains (3) summary
      pfam01608
      Location:973 → 1120
      I_LWEQ; I/LWEQ domain
      pfam07651
      Location:9 → 281
      ANTH; ANTH domain
      pfam07851
      Location:402 → 504
      TMPIT; TMPIT-like protein

    2. NM_168513.2 → NP_729827.1  huntingtin interacting protein 1, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729827.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      B5A7B5, Q86BS5
      Related
      FBpp0075681
      Conserved Domains (3) summary
      pfam01608
      Location:936 → 1083
      I_LWEQ; I/LWEQ domain
      pfam07851
      Location:365 → 467
      TMPIT; TMPIT-like protein
      cl02544
      Location:3 → 244
      VHS_ENTH_ANTH; VHS, ENTH and ANTH domain superfamily; composed of proteins containing a VHS, ENTH or ANTH domain. The VHS domain is present in Vps27 (Vacuolar Protein Sorting), Hrs (Hepatocyte growth factor-regulated tyrosine kinase substrate) and STAM (Signal ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q86BS5 Q86BS5
    Q8MQJ8 Q8MQJ8
    Q8MQK1 Q8MQK1

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