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    SOM1 Som1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856650, updated on 9-Dec-2024

    Summary

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    Official Symbol
    SOM1
    Official Full Name
    Som1p
    Primary source
    SGD:S000002954
    Locus tag
    YEL059C-A
    See related
    AllianceGenome:SGD:S000002954; FungiDB:YEL059C-A; VEuPathDB:YEL059C-A
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to contribute to endopeptidase activity. Involved in mitochondrial respiratory chain complex assembly. Located in mitochondrial inner membrane. Part of mitochondrial inner membrane peptidase complex. [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See SOM1 in Genome Data Viewer
    Location:
    chromosome: V
    Exon count:
    1
    Sequence:
    Chromosome: V; NC_001137.3 (42400..42624, complement)

    Chromosome V - NC_001137.3Genomic Context describing neighboring genes Neighboring gene kinesin motor protein CIN8 Neighboring gene proteinase B Neighboring gene Hhy1p Neighboring gene phosphoacetylglucosamine mutase PCM1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001137.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. SOM 1, a small new gene required for mitochondrial inner membrane peptidase function in Saccharomyces cerevisiae. Esser K, et al. Mol Gen Genet, 1996 Sep 25. PMID 8879245
    2. The Saccharomyces cerevisiae SOM1 gene: heterologous complementation studies, homologues in other organisms, and association of the gene product with the inner mitochondrial membrane. Bauerfeind M, et al. Mol Gen Genet, 1998 Apr. PMID 9604886
    3. Som1, a third component of the yeast mitochondrial inner membrane peptidase complex that contains Imp1 and Imp2. Jan PS, et al. Mol Gen Genet, 2000 Apr. PMID 10821182
    4. Cargo sequences are important for Som1p-dependent signal peptide cleavage in yeast mitochondria. Liang H, et al. J Biol Chem, 2004 Sep 17. PMID 15254042
    5. The mitochondrial IMP peptidase of yeast: functional analysis of domains and identification of Gut2 as a new natural substrate. Esser K, et al. Mol Genet Genomics, 2004 Jun. PMID 15118906

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to endopeptidase activity IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in mitochondrial respiratory chain complex assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial inner membrane peptidase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of mitochondrial inner membrane peptidase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Som1p
    NP_058154.3
    • Subunit of the mitochondrial inner membrane peptidase (IMP); IMP is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001137.3 Reference assembly

      Range
      42400..42624 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180854.3 → NP_058154.3  TPA: Som1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_058154.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D3DLJ1, Q05676
      UniProtKB/TrEMBL
      A6ZQP2, B3LRV9, C7GXE6, C8Z6T2, G2WCH5, N1P578
      Conserved Domains (1) summary
      pfam11093
      Location:1 → 69
      Mitochondr_Som1; Mitochondrial export protein Som1
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05676.1

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