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    TEX1 Tex1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855468, updated on 9-Dec-2024

    Summary

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    Official Symbol
    TEX1
    Official Full Name
    Tex1p
    Primary source
    SGD:S000005197
    Locus tag
    YNL253W
    See related
    AllianceGenome:SGD:S000005197; FungiDB:YNL253W; VEuPathDB:YNL253W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mRNA binding activity. Predicted to be involved in mRNA export from nucleus. Part of transcription export complex. Orthologous to human THOC3 (THO complex subunit 3). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See TEX1 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (170018..171286)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene mRNA-binding translational activator GIS2 Neighboring gene Rtc4p Neighboring gene mitochondrial 54S ribosomal protein YmL17/YmL30 Neighboring gene Nrd1 complex RNA-binding subunit

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural characterization of the Saccharomyces cerevisiae THO complex by small-angle X-ray scattering. Poulsen JB, et al. PLoS One, 2014. PMID 25062267, Free PMC Article
    2. Architecture and nucleic acids recognition mechanism of the THO complex, an mRNP assembly factor. Peña A, et al. EMBO J, 2012 Mar 21. PMID 22314234, Free PMC Article
    3. Structural insights into the nucleic acid remodeling mechanisms of the yeast THO-Sub2 complex. Schuller SK, et al. Elife, 2020 Nov 16. PMID 33191913, Free PMC Article
    4. Cryo-EM structure of the yeast TREX complex and coordination with the SR-like protein Gbp2. Xie Y, et al. Elife, 2021 Mar 31. PMID 33787496, Free PMC Article
    5. A yeast model for polyalanine-expansion aggregation and toxicity. Konopka CA, et al. Mol Biol Cell, 2011 Jun 15. PMID 21508314, Free PMC Article

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables mRNA binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA export from nucleus IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in mRNA export from nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of THO complex part of transcription export complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of transcription export complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Tex1p
    NP_014146.1
    • Protein involved in mRNA export; component of the transcription export (TREX) complex

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      170018..171286
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183091.1 → NP_014146.1  TPA: Tex1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014146.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0U0, P53851
      UniProtKB/TrEMBL
      A6ZRJ0, B3LP97, C7GPA8, N1P517
      Conserved Domains (2) summary
      COG2319
      Location:1 → 374
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:66 → 109
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53851.1

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