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    MOD5 tRNA dimethylallyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854448, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MOD5
    Official Full Name
    tRNA dimethylallyltransferase
    Primary source
    SGD:S000005800
    Locus tag
    YOR274W
    See related
    AllianceGenome:SGD:S000005800; FungiDB:YOR274W; VEuPathDB:YOR274W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables tRNA binding activity and tRNA dimethylallyltransferase activity. Involved in tRNA modification. Located in cytosol; mitochondrion; and nucleolus. Used to study combined oxidative phosphorylation deficiency 35 and lung cancer. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 35. Orthologous to human TRIT1 (tRNA isopentenyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MOD5 in Genome Data Viewer
    Location:
    chromosome: XV
    Exon count:
    1
    Sequence:
    Chromosome: XV; NC_001147.6 (837674..838960)

    Chromosome XV - NC_001147.6Genomic Context describing neighboring genes Neighboring gene Ytm1p Neighboring gene Tpo4p Neighboring gene Rim20p Neighboring gene Caf20p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001147.6

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. MOD5 translation initiation sites determine N6-isopentenyladenosine modification of mitochondrial and cytoplasmic tRNA. Gillman EC, et al. Mol Cell Biol, 1991 May. PMID 1850093, Free PMC Article
    2. Saccharomyces cerevisiae Mod5p-II contains sequences antagonistic for nuclear and cytosolic locations. Tolerico LH, et al. Genetics, 1999 Jan. PMID 9872948, Free PMC Article
    3. Crystallographic snapshots of eukaryotic dimethylallyltransferase acting on tRNA: insight into tRNA recognition and reaction mechanism. Zhou C, et al. Proc Natl Acad Sci U S A, 2008 Oct 21. PMID 18852462, Free PMC Article
    4. DNA sequence and transcript mapping of MOD5: features of the 5' region which suggest two translational starts. Najarian D, et al. Mol Cell Biol, 1987 Jan. PMID 3031457, Free PMC Article
    5. mRNA leader length and initiation codon context determine alternative AUG selection for the yeast gene MOD5. Slusher LB, et al. Proc Natl Acad Sci U S A, 1991 Nov 1. PMID 1946403, Free PMC Article

    See all (47) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mod5 protein binds to tRNA gene complexes and affects local transcriptional silencing.
      Title: Mod5 protein binds to tRNA gene complexes and affects local transcriptional silencing.
    2. identified Mod5 as a yeast prion protein and found that its prion conversion in yeast regulated the sterol biosynthetic pathway for acquired cellular resistance against antifungal agents; selective pressure by antifungal drugs on yeast facilitated the de novo appearance of Mod5 prion states for cell survival
      Title: A yeast prion, Mod5, promotes acquired drug resistance and cell survival under environmental stress.
    3. show that Tit1p accommodates a broader range of substrates than Mod5p
      Title: Plasticity and diversity of tRNA anticodon determinants of substrate recognition by eukaryotic A37 isopentenyltransferases.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA dimethylallyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA dimethylallyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables tRNA dimethylallyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity, transferring alkyl or aryl (other than methyl) groups IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in tRNA modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA modification IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tRNA modification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    tRNA dimethylallyltransferase
    NP_014917.3
    • Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase; required for biosynthesis of isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; also has a role in tRNA gene-mediated silencing; gene encodes two isozymic forms; converts to a prion form, prion conversion contributes to azole antifungal resistance by upregulating ergosterol biosynthesis; homolog of human TRIT1, a mutation in which is associated with severe combined respiratory chain defects

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001147.6 Reference assembly

      Range
      837674..838960
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183693.3 → NP_014917.3  TPA: tRNA dimethylallyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014917.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W2X4, P07884, Q12203
      UniProtKB/TrEMBL
      A6ZPB1, B3LJU0, B5VSF5, C7GWB6, G2WNE2, N1NYT6
      Conserved Domains (1) summary
      TIGR00174
      Location:16 → 320
      miaA; tRNA dimethylallyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07884.2

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