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    Stag3 STAG3 cohesin complex component [ Rattus norvegicus (Norway rat) ]

    Gene ID: 114522, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Stag3provided by RGD
    Official Full Name
    STAG3 cohesin complex componentprovided by RGD
    Primary source
    RGD:621333
    See related
    EnsemblRapid:ENSRNOG00000001360 AllianceGenome:RGD:621333
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable chromatin binding activity. Predicted to be involved in establishment of meiotic sister chromatid cohesion. Predicted to act upstream of or within homologous chromosome pairing at meiosis and protein localization to chromosome. Predicted to be located in chromatin; male germ cell nucleus; and nuclear lumen. Predicted to be part of meiotic cohesin complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in primary ovarian insufficiency 8 and spermatogenic failure 61. Orthologous to human STAG3 (STAG3 cohesin complex component). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Restricted expression toward (RPKM 296.2) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Stag3 in Genome Data Viewer
    Location:
    12q11
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (22398291..22428548)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (17284677..17314936)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (19599741..19630775)

    Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene galactose-3-O-sulfotransferase 4 Neighboring gene glypican 2 Neighboring gene uncharacterized LOC134481272 Neighboring gene PVR related immunoglobulin domain containing Neighboring gene paired immunoglobin like type 2 receptor beta 2 like 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Evaluation of the Stag3 gene and the synaptonemal complex in a rat model (as/as) for male infertility. Bayés M, et al. Mol Reprod Dev, 2001 Nov. PMID 11599053
    2. STAG3, a novel gene encoding a protein involved in meiotic chromosome pairing and location of STAG3-related genes flanking the Williams-Beuren syndrome deletion. Pezzi N, et al. FASEB J, 2000 Mar. PMID 10698974
    3. Identification and molecular characterization of the mammalian α-kleisin RAD21L. Gutiérrez-Caballero C, et al. Cell Cycle, 2011 May 1. PMID 21527826
    4. SYCP2 and SYCP3 are required for cohesin core integrity at diplotene but not for centromere cohesion at the first meiotic division. Kouznetsova A, et al. J Cell Sci, 2005 May 15. PMID 15870106
    5. RAD21L, a novel cohesin subunit implicated in linking homologous chromosomes in mammalian meiosis. Lee J, et al. J Cell Biol, 2011 Jan 24. PMID 21242291, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in establishment of meiotic sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in establishment of meiotic sister chromatid cohesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in establishment of meiotic sister chromatid cohesion ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    acts_upstream_of_or_within homologous chromosome pairing at meiosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in meiotic cell cycle TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within protein localization to chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in sister chromatid cohesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in condensed nuclear chromosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lateral element ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in male germ cell nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of meiotic cohesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of meiotic cohesin complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synaptonemal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in synaptonemal complex TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in transverse filament ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cohesin subunit SA-3
    Names
    SCC3 homolog 3
    cohesin subunit SA-3-like
    stromal antigen 3
    stromalin-3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053730.1 → NP_446182.1  cohesin subunit SA-3

      See identical proteins and their annotated locations for NP_446182.1

      Status: PROVISIONAL

      Source sequence(s)
      AY027880
      UniProtKB/Swiss-Prot
      Q99M76
      UniProtKB/TrEMBL
      A6KSU8, A6KSU9
      Conserved Domains (1) summary
      pfam08514
      Location:188 → 296
      STAG; STAG domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086030.1 Reference GRCr8

      Range
      22398291..22428548
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006249020.4 → XP_006249082.1  cohesin subunit SA-3 isoform X1

      See identical proteins and their annotated locations for XP_006249082.1

      UniProtKB/Swiss-Prot
      Q99M76
      UniProtKB/TrEMBL
      A6KSU8, A6KSU9
      Related
      ENSRNOP00000103947.1, ENSRNOT00000127131.1
      Conserved Domains (1) summary
      pfam08514
      Location:188 → 296
      STAG; STAG domain

    2. XM_039089018.1 → XP_038944946.1  cohesin subunit SA-3 isoform X2

      UniProtKB/TrEMBL
      A6KSU9
      Related
      ENSRNOP00000110662.1, ENSRNOT00000162804.1
      Conserved Domains (1) summary
      pfam08514
      Location:188 → 296
      STAG; STAG domain

    3. XM_039089015.2 → XP_038944943.1  cohesin subunit SA-3 isoform X1

      UniProtKB/Swiss-Prot
      Q99M76
      UniProtKB/TrEMBL
      A6KSU8, A6KSU9
      Conserved Domains (1) summary
      pfam08514
      Location:188 → 296
      STAG; STAG domain

    4. XM_063270988.1 → XP_063127058.1  cohesin subunit SA-3 isoform X2

      UniProtKB/TrEMBL
      A6KSU9

    5. XM_039089017.2 → XP_038944945.1  cohesin subunit SA-3 isoform X1

      UniProtKB/Swiss-Prot
      Q99M76
      UniProtKB/TrEMBL
      A6KSU8, A6KSU9
      Conserved Domains (1) summary
      pfam08514
      Location:188 → 296
      STAG; STAG domain

    6. XM_039089016.2 → XP_038944944.1  cohesin subunit SA-3 isoform X1

      UniProtKB/Swiss-Prot
      Q99M76
      UniProtKB/TrEMBL
      A6KSU8, A6KSU9
      Related
      ENSRNOP00000041918.4, ENSRNOT00000042006.6
      Conserved Domains (1) summary
      pfam08514
      Location:188 → 296
      STAG; STAG domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99M76.1 GenPept UniProtKB/Swiss-Prot:Q99M76

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