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    Tmem39b transmembrane protein 39b [ Mus musculus (house mouse) ]

    Gene ID: 230770, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Tmem39bprovided by MGI
    Official Full Name
    transmembrane protein 39bprovided by MGI
    Primary source
    MGI:MGI:2682939
    See related
    Ensembl:ENSMUSG00000053730 AllianceGenome:MGI:2682939
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    6330509E05Rik
    Summary
    Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane. Orthologous to human TMEM39B (transmembrane protein 39B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis adult (RPKM 76.4), ovary adult (RPKM 22.1) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tmem39b in Genome Data Viewer
    Location:
    4 D2.2; 4 63.31 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (129570145..129595850, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (129676352..129702167, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34305 Neighboring gene taxilin alpha Neighboring gene STARR-positive B cell enhancer ABC_E1283 Neighboring gene karyopherin subunit alpha 6 Neighboring gene STARR-positive B cell enhancer ABC_E7992 Neighboring gene microRNA 7016 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:129378925-129379108 Neighboring gene KH domain containing, RNA binding, signal transduction associated 1 Neighboring gene STARR-seq mESC enhancer starr_11505 Neighboring gene STARR-seq mESC enhancer starr_11507 Neighboring gene STARR-positive B cell enhancer mm9_chr4:129438194-129438495 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:129439040-129439227 Neighboring gene predicted gene 12967

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cracking the egg: molecular dynamics and evolutionary aspects of the transition from the fully grown oocyte to embryo. Evsikov AV, et al. Genes Dev, 2006 Oct 1. PMID 17015433, Free PMC Article
    2. Characterization of an exchangeable gene trap using pU-17 carrying a stop codon-beta geo cassette. Taniwaki T, et al. Dev Growth Differ, 2005 Apr. PMID 15840001
    3. Exchangeable gene trap using the Cre/mutated lox system. Araki K, et al. Cell Mol Biol (Noisy-le-grand), 1999 Jul. PMID 10512203
    4. Construction of long-transcript enriched cDNA libraries from submicrogram amounts of total RNAs by a universal PCR amplification method. Piao Y, et al. Genome Res, 2001 Sep. PMID 11544199, Free PMC Article
    5. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • MGC59407

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 39B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001356378.1 → NP_001343307.1  transmembrane protein 39B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL671759, BF465506, BM122099, CB248417, CV561000, DV656907
      Conserved Domains (1) summary
      pfam10271
      Location:3 → 363
      Tmp39; Putative transmembrane protein

    2. NM_199305.2 → NP_955009.1  transmembrane protein 39B isoform 1

      See identical proteins and their annotated locations for NP_955009.1

      Status: VALIDATED

      Source sequence(s)
      AL671759, BF465506, BM122099, CB248417, CV561000, DV656907
      Consensus CDS
      CCDS18702.1
      UniProtKB/Swiss-Prot
      Q810L4
      Related
      ENSMUSP00000099648.4, ENSMUST00000102588.10
      Conserved Domains (1) summary
      pfam10271
      Location:48 → 478
      Tmp39; Putative transmembrane protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      129570145..129595850 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253455.2 → XP_030109315.1  transmembrane protein 39B isoform X2

      Conserved Domains (1) summary
      pfam10271
      Location:1 → 351
      Tmp39; Putative transmembrane protein

    2. XM_036164058.1 → XP_036019951.1  transmembrane protein 39B isoform X2

      Conserved Domains (1) summary
      pfam10271
      Location:1 → 351
      Tmp39; Putative transmembrane protein

    3. XM_036164055.1 → XP_036019948.1  transmembrane protein 39B isoform X1

      Conserved Domains (1) summary
      pfam10271
      Location:3 → 363
      Tmp39; Putative transmembrane protein

    4. XM_036164056.1 → XP_036019949.1  transmembrane protein 39B isoform X1

      Conserved Domains (1) summary
      pfam10271
      Location:3 → 363
      Tmp39; Putative transmembrane protein

    5. XM_006503046.3 → XP_006503109.1  transmembrane protein 39B isoform X2

      See identical proteins and their annotated locations for XP_006503109.1

      Conserved Domains (1) summary
      pfam10271
      Location:1 → 351
      Tmp39; Putative transmembrane protein

    6. XM_036164057.1 → XP_036019950.1  transmembrane protein 39B isoform X1

      Conserved Domains (1) summary
      pfam10271
      Location:3 → 363
      Tmp39; Putative transmembrane protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q810L4.1 GenPept UniProtKB/Swiss-Prot:Q810L4

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