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    Dipk1c divergent protein kinase domain 1C [ Mus musculus (house mouse) ]

    Gene ID: 240479, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dipk1cprovided by MGI
    Official Full Name
    divergent protein kinase domain 1Cprovided by MGI
    Primary source
    MGI:MGI:3041188
    See related
    Ensembl:ENSMUSG00000047992 AllianceGenome:MGI:3041188
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fam69c; B230399E16Rik
    Summary
    Predicted to be located in endoplasmic reticulum membrane. Is expressed in forelimb bud; lip; sensory organ; and ventricular layer. Orthologous to human DIPK1C (divergent protein kinase domain 1C). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 1.1), frontal lobe adult (RPKM 0.9) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dipk1c in Genome Data Viewer
    Location:
    18 E4; 18 57.53 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (84737133..84762820)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (84719008..84744695)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_45253 Neighboring gene STARR-positive B cell enhancer ABC_E1964 Neighboring gene CNDP dipeptidase 2 Neighboring gene STARR-seq mESC enhancer starr_45255 Neighboring gene WD repeat domain 53 pseudogene Neighboring gene predicted gene, 25005 Neighboring gene predicted gene, 38576 Neighboring gene predicted gene, 17266 Neighboring gene STARR-seq mESC enhancer starr_45257 Neighboring gene STARR-positive B cell enhancer ABC_E8728 Neighboring gene predicted gene 16146 Neighboring gene cytochrome b5 type A (microsomal)

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. FAM69C functions as a kinase for eIF2α and promotes stress granule assembly. Wu Z, et al. EMBO Rep, 2023 May 4. PMID 36929224, Free PMC Article
    2. FAM69C, a kinase critical for synaptic function and memory, is defective in neurodegenerative dementia. Mei F, et al. Cell Rep, 2022 Jul 19. PMID 35858575
    3. Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Lewandowski JP, et al. Dev Biol, 2015 Oct 1. PMID 26238476, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. FAM69C functions as a kinase for eIF2alpha and promotes stress granule assembly.
      Title: FAM69C functions as a kinase for eIF2α and promotes stress granule assembly.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    divergent protein kinase domain 1C
    Names
    family with sequence similarity 69, member C
    protein FAM69C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001408326.1 → NP_001395255.1  divergent protein kinase domain 1C isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC142448
      UniProtKB/Swiss-Prot
      Q8BQT2
      Related
      ENSMUSP00000124603.3, ENSMUST00000161429.3

    2. NM_001408327.1 → NP_001395256.1  divergent protein kinase domain 1C isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC142448

    3. NM_001408328.1 → NP_001395257.1  divergent protein kinase domain 1C isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC142448
      Related
      ENSMUSP00000158524.2, ENSMUST00000235504.2

    4. NM_001408329.1 → NP_001395258.1  divergent protein kinase domain 1C isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC142448

    5. NM_001408330.1 → NP_001395259.1  divergent protein kinase domain 1C isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC142448

    6. NM_173770.6 → NP_776131.1  divergent protein kinase domain 1C isoform 3

      See identical proteins and their annotated locations for NP_776131.1

      Status: VALIDATED

      Source sequence(s)
      AC142448
      Consensus CDS
      CCDS29384.1
      UniProtKB/Swiss-Prot
      Q8BQT2
      Related
      ENSMUSP00000057697.2, ENSMUST00000052501.8
      Conserved Domains (1) summary
      pfam12260
      Location:38 → 206
      PIP49_C; Protein-kinase domain of FAM69

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      84737133..84762820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030250462.2 → XP_030106322.1  divergent protein kinase domain 1C isoform X3

      Conserved Domains (2) summary
      pfam14875
      Location:1 → 106
      PIP49_N; N-term cysteine-rich ER, FAM69
      cl21453
      Location:122 → 223
      PKc_like; Protein Kinases, catalytic domain

    2. XM_036161145.1 → XP_036017038.1  divergent protein kinase domain 1C isoform X4

      Conserved Domains (1) summary
      pfam12260
      Location:38 → 206
      PIP49_C; Protein-kinase domain of FAM69

    3. XM_036161146.1 → XP_036017039.1  divergent protein kinase domain 1C isoform X4

      Conserved Domains (1) summary
      pfam12260
      Location:38 → 206
      PIP49_C; Protein-kinase domain of FAM69

    4. XM_006526475.3 → XP_006526538.1  divergent protein kinase domain 1C isoform X4

      See identical proteins and their annotated locations for XP_006526538.1

      UniProtKB/Swiss-Prot
      Q8BQT2
      Conserved Domains (1) summary
      pfam12260
      Location:38 → 206
      PIP49_C; Protein-kinase domain of FAM69
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BQT2.2 GenPept UniProtKB/Swiss-Prot:Q8BQT2

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