ART5 ADP-ribosyltransferase 5 [Homo sapiens (human)] - Gene

Summary

Official Symbol: ART5provided by HGNC
Official Full Name: ADP-ribosyltransferase 5provided by HGNC
Primary source: HGNC:HGNC:24049
See related: Ensembl:ENSG00000167311 MIM:610625; AllianceGenome:HGNC:24049
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: ARTC5
Summary: The protein encoded by this gene belongs to the ARG-specific ADP-ribosyltransferase family. Proteins in this family regulate the function of target proteins by attaching ADP-ribose to specific amino acid residues in their target proteins. The mouse homolog lacks a glycosylphosphatidylinositol-anchor signal sequence and is predicted to be a secretory enzyme. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Expression: Biased expression in testis (RPKM 6.5), ovary (RPKM 2.3) and 5 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11p15.4

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (3638512..3642379, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (3683946..3687812, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (3659742..3663609, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

LncFALEC recruits ART5/PARP1 and promotes castration-resistant prostate cancer through enhancing PARP1-meditated self PARylation.
Title: LncFALEC recruits ART5/PARP1 and promotes castration-resistant prostate cancer through enhancing PARP1-meditated self PARylation.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables NAD+-protein poly-ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein-arginine ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ecto-ADP-ribosyltransferase 5

Names: ADP-ribosyltransferase C2 and C3 toxin-like 5; NAD(P)(+)--arginine ADP-ribosyltransferase 5; mono(ADP-ribosyl)transferase 5

NP_001073004.1

EC 2.4.2.31

NP_001284597.1

EC 2.4.2.31

NP_443750.2

EC 2.4.2.31

XP_005252836.1

EC 2.4.2.31

XP_006718199.1

EC 2.4.2.31

XP_011518181.1

EC 2.4.2.31

XP_054223583.1

EC 2.4.2.31

XP_054223584.1

EC 2.4.2.31

XP_054223585.1

EC 2.4.2.31

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001079536.2 → NP_001073004.1 ecto-ADP-ribosyltransferase 5 isoform a precursor

See identical proteins and their annotated locations for NP_001073004.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) contains a different 5' UTR compared to transcript variant 1. Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AC060812, AW241897, CD557970, Y16835

Consensus CDS

CCDS7743.1

UniProtKB/Swiss-Prot

C9IYG7, Q6UX84, Q86W02, Q96L15

Related

ENSP00000352992.4, ENST00000359918.8

Conserved Domains (1) summary

pfam01129
Location:28 → 254

ART; NAD:arginine ADP-ribosyltransferase
NM_001297668.2 → NP_001284597.1 ecto-ADP-ribosyltransferase 5 isoform b precursor

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the 3' end of an exon and an alternate splice junction at the 5' end of the last exon compared to variant 1. The resulting isoform (b) lacks an alternate internal segment and has a longer and distinct C-terminus compared to isoform a.

Source sequence(s)

AC060812, AY358466

Consensus CDS

CCDS73242.1

UniProtKB/Swiss-Prot

Q96L15

Related

ENSP00000380257.3, ENST00000397067.7

Conserved Domains (1) summary

cl00173
Location:28 → 196

VIP2; VIP2; A family of actin-ADP-ribosylating toxin. A member of the Bacillus-prodiced vegetative insecticidal proteins (VIPs) possesses high specificity against the major insect pest, corn rootworms, and belongs to a classs of binary toxins and regulators of ...
NM_053017.5 → NP_443750.2 ecto-ADP-ribosyltransferase 5 isoform a precursor

See identical proteins and their annotated locations for NP_443750.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 2 both encode the same isoform (a).

Source sequence(s)

AC060812, BC014577

Consensus CDS

CCDS7743.1

UniProtKB/Swiss-Prot

C9IYG7, Q6UX84, Q86W02, Q96L15

Related

ENSP00000380258.3, ENST00000397068.8

Conserved Domains (1) summary

pfam01129
Location:28 → 254

ART; NAD:arginine ADP-ribosyltransferase

RNA

NR_123732.2 RNA Sequence

Status: REVIEWED

Description

Transcript Variant: This variant (4) uses an alternate splice junction at the 3' end of the first exon and and alternate splice junction at the 5' end of the second exon compared to variant 1. This variant is represented as non-coding because it lacks a large portion of the coding region, including the translational start codon, found in variant 1.

Source sequence(s)

AC060812, BC014577, HY018364