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    Pect Phosphoethanolamine cytidylyltransferase [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 34716, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Pectprovided by FlyBase
    Official Full Name
    Phosphoethanolamine cytidylyltransferaseprovided by FlyBase
    Primary source
    FLYBASE:FBgn0032482
    Locus tag
    Dmel_CG5547
    See related
    AllianceGenome:FB:FBgn0032482
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG5547; Dmel\CG5547; pect; PECT
    Summary
    Enables ethanolamine-phosphate cytidylyltransferase activity. Involved in phosphatidylethanolamine biosynthetic process. Is active in cytosol. Is expressed in adult head and outer photoreceptor cell. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 82. Orthologous to human PCYT2 (phosphate cytidylyltransferase 2, ethanolamine). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

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    See Pect in Genome Data Viewer
    Location:
    34A9-34A9; 2-47 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (13203762..13210828)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (13203762..13210828)

    Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Radial spoke head protein 1 Neighboring gene ER degradation enhancer, mannosidase alpha-like 2 Neighboring gene uncharacterized protein Neighboring gene small nuclear RNA U2 at 34AB a Neighboring gene uncharacterized protein Neighboring gene kekkon 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Fat body phospholipid state dictates hunger-driven feeding behavior. Kelly KP, et al. Elife, 2022 Oct 6. PMID 36201241, Free PMC Article
    2. Wrapping axons in mammals and Drosophila: Different lipids, same principle. Murate M, et al. Biochimie, 2020 Nov. PMID 32800899
    3. A global in vivo Drosophila RNAi screen identifies a key role of ceramide phosphoethanolamine for glial ensheathment of axons. Ghosh A, et al. PLoS Genet, 2013. PMID 24348263, Free PMC Article
    4. Ceramide phosphoethanolamine, an enigmatic cellular membrane sphingolipid. Panevska A, et al. Biochim Biophys Acta Biomembr, 2019 Jul 1. PMID 31067435
    5. Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in Drosophila. Lim HY, et al. Genes Dev, 2011 Jan 15. PMID 21245170, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. PE homeostasis rebalanced through mitochondria-ER lipid exchange prevents retinal degeneration in Drosophila.
      Title: PE homeostasis rebalanced through mitochondria-ER lipid exchange prevents retinal degeneration in Drosophila.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ethanolamine-phosphate cytidylyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ethanolamine-phosphate cytidylyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ethanolamine-phosphate cytidylyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ethanolamine-phosphate cytidylyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphatidylethanolamine biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidylethanolamine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in phosphatidylethanolamine biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phosphatidylethanolamine biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    phosphoethanolamine cytidylyltransferase
    Names
    CG5547-PB
    CG5547-PC
    CG5547-PD
    CG5547-PE
    Pect-PB
    Pect-PC
    Pect-PD
    Pect-PE
    NP_609613.2
    NP_723789.2
    NP_723790.2
    NP_723791.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033779.5 Reference assembly

      Range
      13203762..13210828
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_165028.2 → NP_723789.2  phosphoethanolamine cytidylyltransferase, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723789.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VK24, Q9VK25
      Related
      FBpp0080020
      Conserved Domains (3) summary
      PTZ00308
      Location:16 → 381
      PTZ00308; ethanolamine-phosphate cytidylyltransferase; Provisional
      cd02173
      Location:223 → 373
      ECT; CTP:phosphoethanolamine cytidylyltransferase (ECT)
      cd02174
      Location:19 → 165
      CCT; CTP:phosphocholine cytidylyltransferase

    2. NM_165029.2 → NP_723790.2  phosphoethanolamine cytidylyltransferase, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723790.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86PD6, Q8IP80
      Related
      FBpp0080022
      Conserved Domains (3) summary
      PTZ00308
      Location:16 → 369
      PTZ00308; ethanolamine-phosphate cytidylyltransferase; Provisional
      cd02173
      Location:211 → 361
      ECT; CTP:phosphoethanolamine cytidylyltransferase (ECT)
      cd02174
      Location:19 → 165
      CCT; CTP:phosphocholine cytidylyltransferase

    3. NM_165030.2 → NP_723791.2  phosphoethanolamine cytidylyltransferase, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_723791.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IP79
      Related
      FBpp0080021
      Conserved Domains (3) summary
      PTZ00308
      Location:16 → 362
      PTZ00308; ethanolamine-phosphate cytidylyltransferase; Provisional
      cd02173
      Location:204 → 354
      ECT; CTP:phosphoethanolamine cytidylyltransferase (ECT)
      cd02174
      Location:19 → 165
      CCT; CTP:phosphocholine cytidylyltransferase

    4. NM_135769.3 → NP_609613.2  phosphoethanolamine cytidylyltransferase, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_609613.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q7KTB3
      Conserved Domains (3) summary
      PTZ00308
      Location:16 → 359
      PTZ00308; ethanolamine-phosphate cytidylyltransferase; Provisional
      cd02173
      Location:201 → 351
      ECT; CTP:phosphoethanolamine cytidylyltransferase (ECT)
      cd02174
      Location:19 → 165
      CCT; CTP:phosphocholine cytidylyltransferase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7KTB3 Q7KTB3
    Q8IP79 Q8IP79
    Q8IP80 Q8IP80
    Q95SU1 Q95SU1
    Q9VK25 Q9VK25

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