Grxcr2 glutaredoxin and cysteine rich domain containing 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Grxcr2provided by RGD
Official Full Name: glutaredoxin and cysteine rich domain containing 2provided by RGD
Primary source: RGD:1584696
See related: EnsemblRapid:ENSRNOG00000039325 AllianceGenome:RGD:1584696
Gene type: protein coding
RefSeq status: INFERRED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in sensory perception of sound. Predicted to act upstream of or within auditory receptor cell stereocilium organization and protein localization to organelle. Predicted to be active in microvillus; stereocilium base; and stereocilium shaft. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 101. Orthologous to human GRXCR2 (glutaredoxin and cysteine rich domain containing 2). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human mouse all
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Genomic context

Location:: 18p11

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	18	NC_086036.1 (34235734..34249139, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	18	NC_051353.1 (33984689..33998094, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	18	NC_005117.4 (36308925..36334643, complement)

Chromosome 18 - NC_086036.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Process	Evidence Code	Pubs
acts_upstream_of_or_within auditory receptor cell stereocilium organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within inner ear receptor cell stereocilium organization	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within protein localization to organelle	ISO Inferred from Sequence Orthology more info
involved_in sensory perception of sound	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sensory perception of sound	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in microvillus	IBA Inferred from Biological aspect of Ancestor more info
located_in microvillus	ISO Inferred from Sequence Orthology more info
is_active_in stereocilium base	IBA Inferred from Biological aspect of Ancestor more info
located_in stereocilium base	ISO Inferred from Sequence Orthology more info
is_active_in stereocilium shaft	IBA Inferred from Biological aspect of Ancestor more info
located_in stereocilium shaft	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: glutaredoxin domain-containing cysteine-rich protein 2

Names: glutaredoxin, cysteine rich 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191078.1 → NP_001178007.1 glutaredoxin domain-containing cysteine-rich protein 2

Status: INFERRED

Source sequence(s)

JAXUCZ010000018

UniProtKB/TrEMBL

D4ABJ8

Related

ENSRNOP00000057011.3, ENSRNOT00000060260.4

Conserved Domains (1) summary

cl00388
Location:197 → 243

Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold