U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    itsn1 intersectin 1 [ Xenopus tropicalis (tropical clawed frog) ]

    Gene ID: 733480, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    itsn1provided by Xenbase
    Official Full Name
    intersectin 1provided by Xenbase
    Primary source
    Xenbase:XB-GENE-5904194
    See related
    Ensembl:ENSXETG00000014182 AllianceGenome:Xenbase:XB-GENE-5904194
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus tropicalis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
    Summary
    Predicted to enable calcium ion binding activity and guanyl-nucleotide exchange factor activity. Predicted to act upstream of or within endocytosis and intracellular signal transduction. Predicted to be located in cell projection; cytoplasm; and synapse. Orthologous to human ITSN1 (intersectin 1). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    human mouse all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See itsn1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    104 current UCB_Xtro_10.0 (GCF_000004195.4) 2 NC_030678.2 (14139370..14222077)
    103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 2 NC_030678.1 (10049854..10133319)

    Chromosome 2 - NC_030678.2Genomic Context describing neighboring genes Neighboring gene downstream neighbor of SON Neighboring gene crystallin zeta like 1 Neighboring gene ATP synthase peripheral stalk subunit OSCP Neighboring gene small integral membrane protein 11

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables guanyl-nucleotide exchange factor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within endocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    intersectin-1
    Names
    intersectin 1 (SH3 domain protein)

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference UCB_Xtro_10.0 Primary Assembly

    Genomic

    1. NC_030678.2 Reference UCB_Xtro_10.0 Primary Assembly

      Range
      14139370..14222077
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_002939344.5 → XP_002939390.1  intersectin-1 isoform X1

      UniProtKB/TrEMBL
      A0A6I8RZX2, A0A8J0QQX0
      Related
      ENSXETP00000090953.1, ENSXETT00000076278.2
      Conserved Domains (16) summary
      cd08375
      Location:1570 → 1704
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:217 → 312
      EH; Eps15 homology domain
      cd11987
      Location:740 → 794
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:905 → 956
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:994 → 1045
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:1062 → 1126
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:1146 → 1199
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      cd00052
      Location:26 → 90
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cd13264
      Location:1436 → 1567
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain
      pfam00169
      Location:1453 → 1559
      PH; PH domain
      pfam00621
      Location:1230 → 1410
      RhoGEF; RhoGEF domain
      pfam13868
      Location:365 → 705
      TPH; Trichohyalin-plectin-homology domain
      pfam16617
      Location:794 → 905
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cd16269
      Location:454 → 465
      GBP_C; coiled coil [structural motif]
      cl00936
      Location:572 → 683
      RecX; RecX family
      cl20817
      Location:368 → 487
      GBP_C; Guanylate-binding protein, C-terminal domain

    2. XM_004912127.4 → XP_004912184.1  intersectin-1 isoform X2

      UniProtKB/TrEMBL
      A0A6I8RZX2, F6PVL3
      Related
      ENSXETP00000030993.4, ENSXETT00000030993.5
      Conserved Domains (11) summary
      PTZ00121
      Location:353 → 700
      PTZ00121; MAEBL; Provisional
      cd08375
      Location:1569 → 1703
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:217 → 312
      EH; Eps15 homology domain
      cd11987
      Location:739 → 793
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:904 → 955
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:993 → 1044
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:1061 → 1125
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:1145 → 1198
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      cd00160
      Location:1225 → 1408
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam16617
      Location:793 → 904
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:1427 → 1580
      PH_13; Pleckstrin homology domain

    3. XM_004912128.4 → XP_004912185.1  intersectin-1 isoform X3

      UniProtKB/TrEMBL
      A0A6I8RZX2, A0A6I8S9B4
      Related
      ENSXETP00000089769.2, ENSXETT00000070277.2
      Conserved Domains (16) summary
      cd08375
      Location:1512 → 1646
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:159 → 254
      EH; Eps15 homology domain
      cd11987
      Location:682 → 736
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:847 → 898
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:936 → 987
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:1004 → 1068
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:1088 → 1141
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      cd00052
      Location:26 → 90
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      cd13264
      Location:1378 → 1509
      PH_ITSN; Intersectin Pleckstrin homology (PH) domain
      pfam00169
      Location:1395 → 1501
      PH; PH domain
      pfam00621
      Location:1172 → 1352
      RhoGEF; RhoGEF domain
      pfam13868
      Location:307 → 647
      TPH; Trichohyalin-plectin-homology domain
      pfam16617
      Location:736 → 847
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cd16269
      Location:396 → 407
      GBP_C; coiled coil [structural motif]
      cl00936
      Location:514 → 625
      RecX; RecX family
      cl20817
      Location:310 → 429
      GBP_C; Guanylate-binding protein, C-terminal domain

    4. XM_004912129.4 → XP_004912186.1  intersectin-1 isoform X4

      UniProtKB/TrEMBL
      A0A6I8RZX2, A0A8J0R1V6
      Conserved Domains (11) summary
      PTZ00121
      Location:295 → 642
      PTZ00121; MAEBL; Provisional
      cd08375
      Location:1511 → 1645
      C2_Intersectin; C2 domain present in Intersectin
      smart00027
      Location:159 → 254
      EH; Eps15 homology domain
      cd11987
      Location:681 → 735
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11989
      Location:846 → 897
      SH3_Intersectin1_2; Second Src homology 3 domain (or SH3B) of Intersectin-1
      cd11991
      Location:935 → 986
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11993
      Location:1003 → 1067
      SH3_Intersectin1_4; Fourth Src homology 3 domain (or SH3D) of Intersectin-1
      cd11995
      Location:1087 → 1140
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      cd00160
      Location:1167 → 1350
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      pfam16617
      Location:735 → 846
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      pfam16652
      Location:1369 → 1522
      PH_13; Pleckstrin homology domain

    5. XM_004912130.4 → XP_004912187.1  intersectin-1 isoform X5

      UniProtKB/TrEMBL
      A0A6I8S5R7
      Related
      ENSXETP00000093519.2, ENSXETT00000098365.2
      Conserved Domains (11) summary
      smart00027
      Location:217 → 312
      EH; Eps15 homology domain
      cd11987
      Location:740 → 794
      SH3_Intersectin1_1; First Src homology 3 domain (or SH3A) of Intersectin-1
      cd11991
      Location:994 → 1045
      SH3_Intersectin1_3; Third Src homology 3 domain (or SH3C) of Intersectin-1
      cd11995
      Location:1146 → 1199
      SH3_Intersectin1_5; Fifth Src homology 3 domain (or SH3E) of Intersectin-1
      cd00052
      Location:26 → 90
      EH; Eps15 homology domain; found in proteins implicated in endocytosis, vesicle transport, and signal transduction. The alignment contains a pair of EF-hand motifs, typically one of them is canonical and binds to Ca2+, while the other may not bind to Ca2+. A ...
      pfam13868
      Location:365 → 705
      TPH; Trichohyalin-plectin-homology domain
      pfam16617
      Location:794 → 905
      INTAP; Intersectin and clathrin adaptor AP2 binding region
      cd16269
      Location:454 → 465
      GBP_C; coiled coil [structural motif]
      cl00936
      Location:572 → 683
      RecX; RecX family
      cl17036
      Location:1062 → 1126
      SH3; Src Homology 3 domain superfamily
      cl20817
      Location:368 → 487
      GBP_C; Guanylate-binding protein, C-terminal domain
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.