Taz Tafazzin [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Tazprovided by FlyBase
Official Full Name: Tafazzinprovided by FlyBase
Primary source: FLYBASE:FBgn0026619
Locus tag: Dmel_CG8766
See related: AllianceGenome:FB:FBgn0026619
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: CG8766; Dmel\CG8766; dTaz; dTAZ; tafazzin; taz; TAZ
Summary: Enables phosphatidylcholine:cardiolipin O-linoleoyltransferase activity. Involved in cardiolipin acyl-chain remodeling; cardiolipin biosynthetic process; and sperm individualization. Located in Golgi apparatus; endoplasmic reticulum; and mitochondrion. Is expressed in several structures, including adult head; embryonic Malpighian tubule; embryonic/larval midgut primordium; and gut section. Used to study Barth syndrome. Human ortholog(s) of this gene implicated in Barth syndrome and dilated cardiomyopathy. Orthologous to human TAFAZZIN (tafazzin, phospholipid-lysophospholipid transacylase). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Genomic context

Location:: 49C2-49C2; 2-67 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (12753026..12756414, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (8640531..8643919, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of TAZ function leads to exercise intolerance in Drosophila.
Title: Drosophila tafazzin mutants have impaired exercise capacity.
propose that tafazzin reacts with non-bilayer-type lipid domains that occur in curved or hemifused membrane zones and that acyl specificity is driven by the packing properties of these domains
Title: The physical state of lipid substrates provides transacylation specificity for tafazzin.
the characteristic fatty acid profile of cardiolipin is not determined by the substrate specificity of tafazzin
Title: Characterization of tafazzin splice variants from humans and fruit flies.
The data suggest that tafazzin deficiency affects cardiolipin in all mitochondria, but significant alterations of the ultrastructure, such as remodeling and aggregation of inner membranes, will only occur after specific differentiation.
Title: Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria.
tafazzin deficiency in Drosophila disrupts the final stage of spermatogenesis, spermatid individualization, and causes male sterility
Title: Role of calcium-independent phospholipase A2 in the pathogenesis of Barth syndrome.
Data show that tafazzin mutations in Drosophila generate a Barth-related phenotype, with the triad of abnormal cardiolipin, pathologic mitochondria, and motor weakness, suggesting causal links between these findings.
Title: A Drosophila model of Barth syndrome.
Drosophila tafazzin is a CoA-independent, acyl-specific phospholipid transacylase with substrate preference for cardiolipin and phosphatidylcholine
Title: The enzymatic function of tafazzin.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables 1-acylglycerophosphocholine O-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables O-acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acyltransferase activity	IDA Inferred from Direct Assay more info	PubMed
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables phosphatidylcholine:cardiolipin O-linoleoyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in cardiolipin acyl-chain remodeling	IBA Inferred from Biological aspect of Ancestor more info
involved_in cardiolipin acyl-chain remodeling	IDA Inferred from Direct Assay more info	PubMed
involved_in cardiolipin biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cardiolipin metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in inner mitochondrial membrane organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of mitochondrial membrane organization	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipid metabolic process	IC Inferred by Curator more info	PubMed
involved_in phospholipid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phospholipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in sperm individualization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrial intermembrane space	TAS Traceable Author Statement more info	PubMed
is_active_in mitochondrial membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tafazzin

Names: CG8766-PA; CG8766-PB; CG8766-PC; CG8766-PD; Taz-PA; Taz-PB; Taz-PC; Taz-PD; tafazzins

NP_001188916.1

EC 2.3.-.-

EC 2.3.1.23

NP_477432.3

EC 2.3.-.-

EC 2.3.1.23

NP_725226.2

EC 2.3.-.-

EC 2.3.1.23

NP_725227.2

EC 2.3.-.-

EC 2.3.1.23

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

12753026..12756414 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_058084.5 → NP_477432.3 tafazzin, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_477432.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q8ML32, Q8SZ79, Q9U9U8, Q9V6G4, Q9V6G5

UniProtKB/TrEMBL

C6SUZ0

Related

FBpp0086975

Conserved Domains (1) summary

cd07989
Location:153 → 360

LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
NM_165947.2 → NP_725226.2 tafazzin, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725226.2

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4JD45, C6SUZ0

Related

FBpp0086976

Conserved Domains (1) summary

cd07989
Location:53 → 260

LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
NM_001201987.2 → NP_001188916.1 tafazzin, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001188916.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4JD45, C6SUZ0

Conserved Domains (1) summary

cd07989
Location:53 → 260

LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like
NM_165948.2 → NP_725227.2 tafazzin, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_725227.2

Status: REVIEWED

UniProtKB/TrEMBL

C6SUZ0, H0RNE3

Related

FBpp0086977

Conserved Domains (1) summary

cd07989
Location:113 → 320

LPLAT_AGPAT-like; Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like