Pip5k1a phosphatidylinositol-4-phosphate 5-kinase, type 1 alpha [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pip5k1aprovided by MGI
Official Full Name: phosphatidylinositol-4-phosphate 5-kinase, type 1 alphaprovided by MGI
Primary source: MGI:MGI:107929
See related: Ensembl:ENSMUSG00000028126 AllianceGenome:MGI:107929
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pipk5a; PI4P5K-I[a]; PIP5KIalpha; PIP5K1-alpha
Summary: Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity. Acts upstream of or within fibroblast migration and phosphatidylinositol biosynthetic process. Located in cytosol; nucleus; and ruffle membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PIP5K1A (phosphatidylinositol-4-phosphate 5-kinase type 1 alpha). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information: Note: This record was renamed from Pip5k1b to Pip5k1a to conform to the annotation of human. [03 Apr 2007]
Expression: Ubiquitous expression in placenta adult (RPKM 12.5), limb E14.5 (RPKM 11.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 F2.1; 3 40.74 cM

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (94965841..95014241, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (95058530..95106930, complement)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Localization of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) alpha confined to the surface of lipid droplets and adjacent narrow cytoplasm in progesterone-producing cells of in situ ovaries of adult mice.
Title: Localization of phosphatidylinositol 4-phosphate 5-kinase (PIP5K) α confined to the surface of lipid droplets and adjacent narrow cytoplasm in progesterone-producing cells of in situ ovaries of adult mice.
PIP5K1alpha was found to be required for AKT activation and calcium release, both of which were important for skeletal muscle differentiation.
Title: PIP5K1α promotes myogenic differentiation via AKT activation and calcium release.
these results support that PIP5Kalpha can positively mediate TLR2-associated immune responses through Phosphatidylinositol 4,5-bisphosphate production in microglial cells.
Title: Phosphatidylinositol 4-phosphate 5-kinase α contributes to Toll-like receptor 2-mediated immune responses in microglial cells stimulated with lipoteichoic acid.
Data suggest that c-Fos (proto-oncogene protein c-fos; not c-Jun) regulates phospholipid synthesis in cell nucleus; c-Fos localizes to nucleus and modulates genetic transcription through activation of Pip5k1.
Title: c-Fos-activated synthesis of nuclear phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P₂] promotes global transcriptional changes.
optimal PIP5KIgamma and PI(4,5)P(2) expression, by osteoclasts, are essential for skeletal homeostasis
Title: Type I phosphotidylinosotol 4-phosphate 5-kinase γ regulates osteoclasts in a bifunctional manner.
Our findings suggest that PI4P5Kalpha plays a complex role in restricting insulin release from pancreatic beta-cells through helping to maintain plasma membrane PIP(2) levels and integrity of the actin cytoskeleton under both basal and stimulatory conditions.
Title: Phosphatidylinositol-4-phosphate-5-kinase alpha deficiency alters dynamics of glucose-stimulated insulin release to improve glucohomeostasis and decrease obesity in mice.
The results suggested that PIP5K1A and PIP5K1B may coordinately and/or redundantly function in the maintenance of sperm number and morphology during spermatogenesis.
Title: Phosphatidylinositol 4-phosphate 5-kinase is indispensable for mouse spermatogenesis.
PIP5K-Ialpha may play an important role in both the proximal and distal steps of signaling cascade for insulin secretion in beta-cells.
Title: Role of type Ialpha phosphatidylinositol-4-phosphate 5-kinase in insulin secretion, glucose metabolism, and membrane potential in INS-1 beta-cells.
after stimulation of a G protein-coupled receptor, IP(3) is completely derived from a rapidly synthesized discrete pool of PIP(2) synthesized by PIP5KIalpha and PIP5KIbeta
Title: Loss of PIP5KIbeta demonstrates that PIP5KI isoform-specific PIP2 synthesis is required for IP3 formation.
that membrane turnover events regulating ENaC surface expression and activity in oocytes and CCD cells can be regulated by PI5KIalpha.
Title: Phosphatidylinositol 4-phosphate 5-kinase reduces cell surface expression of the epithelial sodium channel (ENaC) in cultured collecting duct cells.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Gene trapped (2) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Pip5k1a (e-PCR), detects polymorphism
- UniSTS:507141

D3Umi8 (e-PCR), detects polymorphism
- UniSTS:281107

D86177 (e-PCR)
- UniSTS:163318

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables 1-phosphatidylinositol-4-phosphate 5-kinase activity	ISO Inferred from Sequence Orthology more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	IEA Inferred from Electronic Annotation more info
enables kinase binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in activation of GTPase activity	ISO Inferred from Sequence Orthology more info
involved_in activation of GTPase activity	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in cell chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within fibroblast migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in focal adhesion assembly	ISO Inferred from Sequence Orthology more info
involved_in focal adhesion assembly	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within phosphatidylinositol biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within phosphatidylinositol metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phospholipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISO Inferred from Sequence Orthology more info
involved_in protein localization to plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
involved_in ruffle assembly	ISO Inferred from Sequence Orthology more info
involved_in ruffle assembly	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in lamellipodium	ISO Inferred from Sequence Orthology more info
part_of mRNA cleavage and polyadenylation specificity factor complex	IEA Inferred from Electronic Annotation more info
part_of mRNA cleavage and polyadenylation specificity factor complex	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in ruffle membrane	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

Names: 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase; 68 kDa type I phosphatidylinositol 4-phosphate 5-kinase alpha; phosphatidylinositol 4-phosphate 5-kinase type I alpha; ptdIns(4)P-5-kinase 1 alpha

NP_001280636.1

EC 2.7.1.68

NP_032873.2

EC 2.7.1.68

XP_036018829.1

EC 2.7.1.68

XP_036018830.1

EC 2.7.1.68

XP_036018831.1

EC 2.7.1.68

XP_036018832.1

EC 2.7.1.68

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001293707.2 → NP_001280636.1 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 1

See identical proteins and their annotated locations for NP_001280636.1

Status: VALIDATED

Source sequence(s)

AC087062, AC131769

Consensus CDS

CCDS79980.1

UniProtKB/TrEMBL

F8WI18

Related

ENSMUSP00000102852.3, ENSMUST00000107233.9

Conserved Domains (1) summary

smart00330
Location:95 → 435

PIPKc; Phosphatidylinositol phosphate kinases
NM_001428682.1 → NP_001415611.1 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 3

Status: VALIDATED

Source sequence(s)

AC087062, AC131769
NM_008847.4 → NP_032873.2 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform 2

See identical proteins and their annotated locations for NP_032873.2

Status: VALIDATED

Source sequence(s)

AC087062, AC131769

Consensus CDS

CCDS38542.1

UniProtKB/Swiss-Prot

F8WIX5, P70182, Q3U917, Q8K0D3, Q99L80

UniProtKB/TrEMBL

F8WI18

Related

ENSMUSP00000102855.3, ENSMUST00000107236.9

Conserved Domains (1) summary

smart00330
Location:94 → 434

PIPKc; Phosphatidylinositol phosphate kinases

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000069.7 Reference GRCm39 C57BL/6J

Range

94965841..95014241 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036162939.1 → XP_036018832.1 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X4

Related

ENSMUSP00000102851.3, ENSMUST00000107232.9

Conserved Domains (1) summary

cd17306
Location:65 → 439

PIPKc_PIP5K1A_like; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1alpha) and similar proteins
XM_036162937.1 → XP_036018830.1 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X2

UniProtKB/TrEMBL

D3YUY3

Conserved Domains (1) summary

cd17306
Location:79 → 453

PIPKc_PIP5K1A_like; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1alpha) and similar proteins
XM_036162936.1 → XP_036018829.1 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X1

UniProtKB/TrEMBL

F8WI18

Conserved Domains (1) summary

cd17306
Location:79 → 454

PIPKc_PIP5K1A_like; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1alpha) and similar proteins
XM_036162938.1 → XP_036018831.1 phosphatidylinositol 4-phosphate 5-kinase type-1 alpha isoform X3

UniProtKB/TrEMBL

F8WI18

Conserved Domains (1) summary

cd17306
Location:22 → 397

PIPKc_PIP5K1A_like; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in phosphatidylinositol 4-phosphate 5-kinase type-1 alpha (PIP5K1alpha) and similar proteins