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    rdgA retinal degeneration A [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 31826, updated on 9-Dec-2024

    Summary

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    Official Symbol
    rdgAprovided by FlyBase
    Official Full Name
    retinal degeneration Aprovided by FlyBase
    Primary source
    FLYBASE:FBgn0261549
    Locus tag
    Dmel_CG42667
    See related
    AllianceGenome:FB:FBgn0261549
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG10966; CG12660; CG15352; CG34344; CG42667; dDGK2; dgk; DGK; dgk-5; DGK2; Dmel\CG42667; RdgA; RDGA; x35
    Old locus tag
    CG10966; CG12660; Dmel_CG10966; Dmel_CG12660; Dmel_CG15352; Dmel_CG34344
    Summary
    Enables ATP-dependent diacylglycerol kinase activity. Involved in several processes, including G protein-coupled opsin signaling pathway; negative regulation of opsin-mediated signaling pathway; and thermotaxis. Predicted to be active in membrane. Is expressed in Bolwig organ; adult head; eye; and spermatozoon. Orthologous to several human genes including DGKI (diacylglycerol kinase iota). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See rdgA in Genome Data Viewer
    Location:
    8B7-8C3; 1-26 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) X NC_004354.4 (8907068..9029476)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) X NC_004354.3 (8801101..8923509)

    Chromosome X - NC_004354.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44111 Neighboring gene RNA-binding motif protein 13 Neighboring gene enhancer of rudimentary Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR43836 Neighboring gene mir-4964 stem loop Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene mir-31b stem loop Neighboring gene Nostrin Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structure of retinular cells in a Drosophila melanogaster visual mutant, rdgA, at early stages of degeneration. Matsumoto E, et al. Cell Tissue Res, 1988 May. PMID 3133115
    2. Immunolocalization of a Drosophila phosphatidylinositol transfer protein (rdgB) in normal and rdgA mutant photoreceptor cells with special reference to the subrhabdomeric cisternae. Suzuki E, et al. J Electron Microsc (Tokyo), 1994 Aug. PMID 7996077
    3. Drosophila retinal degeneration A gene encodes an eye-specific diacylglycerol kinase with cysteine-rich zinc-finger motifs and ankyrin repeats. Masai I, et al. Proc Natl Acad Sci U S A, 1993 Dec 1. PMID 8248222, Free PMC Article
    4. Predicting RNA hyper-editing with a novel tool when unambiguous alignment is impossible. McKerrow WH, et al. BMC Genomics, 2017 Jul 10. PMID 28693467, Free PMC Article
    5. Analysis of photoreceptor membrane turnover in a Drosophila visual mutant, rdgA, by electron microscope autoradiography. Suzuki E, et al. J Electron Microsc (Tokyo), 1990. PMID 2358773

    See all (154) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Reduced odor responses from antennal neurons of rdgA mutants in Drosophila support a role for a phospholipid intermediate in insect olfactory transduction.
      Title: Reduced odor responses from antennal neurons of G(q)alpha, phospholipase Cbeta, and rdgA mutants in Drosophila support a role for a phospholipid intermediate in insect olfactory transduction.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    mobile_element

    • Loc: 8922385-8922744 mobile_element_type = transposon:jockey{}87
    • Loc: 8927642-8928286 mobile_element_type = transposon:FB{}rdgA[FB.1613]
    • Loc: 8948814-8956265 mobile_element_type = transposon:roo{}89

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP-dependent diacylglycerol kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP-dependent diacylglycerol kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables ATP-dependent diacylglycerol kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled opsin signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in diacylglycerol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid phosphorylation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of opsin-mediated signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidic acid biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in phosphatidylinositol biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in photoreceptor cell maintenance TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in phototransduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phototransduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in sensory perception of smell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in thermotaxis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    retinal degeneration A
    Names
    CG42667-PA
    CG42667-PB
    CG42667-PC
    CG42667-PD
    CG42667-PE
    CG42667-PG
    CG42667-PH
    CG42667-PI
    CG42667-PJ
    CG42667-PK
    CG42667-PL
    DAG kinase
    DAG-kinase
    diacylglycerol kinase
    rdgA-PA
    rdgA-PB
    rdgA-PC
    rdgA-PD
    rdgA-PE
    rdgA-PG
    rdgA-PH
    rdgA-PI
    rdgA-PJ
    rdgA-PK
    rdgA-PL
    receptor degeneration A
    receptor-degeneration-I
    NP_001036264.2
    NP_001096916.1
    NP_001096917.1
    NP_001188564.1
    NP_001188565.1
    NP_001259366.1
    NP_001259367.1
    NP_001285027.1
    NP_001285028.1
    NP_001368977.1
    NP_511092.2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_004354.4 Reference assembly

      Range
      8907068..9029476
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001201635.1 → NP_001188564.1  retinal degeneration A, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188564.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MSN3
      Conserved Domains (8) summary
      smart00045
      Location:498 → 652
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:348 → 471
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:347 → 669
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00204
      Location:876 → 994
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00130
      Location:125 → 174
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam12796
      Location:877 → 972
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:876 → 903
      ANK; ANK repeat [structural motif]
      cl00040
      Location:195 → 259
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...

    2. NM_001042799.2 → NP_001036264.2  retinal degeneration A, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001036264.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A023GPM5
      Conserved Domains (7) summary
      smart00045
      Location:498 → 652
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:348 → 471
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:347 → 669
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00204
      Location:858 → 976
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00130
      Location:125 → 174
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam12796
      Location:859 → 954
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:858 → 885
      ANK; ANK repeat [structural motif]

    3. NM_001103447.4 → NP_001096917.1  retinal degeneration A, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096917.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09103
      Conserved Domains (7) summary
      smart00045
      Location:531 → 685
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:381 → 504
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:380 → 702
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00204
      Location:891 → 1009
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00130
      Location:158 → 207
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam12796
      Location:892 → 987
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:891 → 918
      ANK; ANK repeat [structural motif]

    4. NM_001103446.2 → NP_001096916.1  retinal degeneration A, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001096916.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q09103
      Conserved Domains (7) summary
      smart00045
      Location:516 → 670
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:366 → 489
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:365 → 687
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00204
      Location:894 → 1012
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00130
      Location:143 → 192
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam12796
      Location:895 → 990
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:894 → 921
      ANK; ANK repeat [structural motif]

    5. NM_001272438.1 → NP_001259367.1  retinal degeneration A, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259367.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PH20
      Conserved Domains (7) summary
      smart00045
      Location:967 → 1121
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:817 → 940
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:816 → 1138
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00204
      Location:1327 → 1445
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00130
      Location:594 → 643
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam12796
      Location:1328 → 1423
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:1327 → 1354
      ANK; ANK repeat [structural motif]

    6. NM_001272437.1 → NP_001259366.1  retinal degeneration A, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001259366.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9PHG3
      Conserved Domains (7) summary
      smart00045
      Location:969 → 1123
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:814 → 942
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:813 → 1140
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00204
      Location:1329 → 1447
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00130
      Location:591 → 640
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam12796
      Location:1330 → 1425
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:1329 → 1356
      ANK; ANK repeat [structural motif]

    7. NM_001201636.1 → NP_001188565.1  retinal degeneration A, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001188565.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      M9MS31
      Conserved Domains (7) summary
      smart00045
      Location:959 → 1113
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:809 → 932
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:808 → 1130
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00204
      Location:1319 → 1437
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00130
      Location:592 → 641
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam12796
      Location:1320 → 1415
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:1319 → 1346
      ANK; ANK repeat [structural motif]

    8. NM_001298099.1 → NP_001285028.1  retinal degeneration A, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285028.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JEJ9
      Conserved Domains (4) summary
      smart00045
      Location:969 → 1123
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:814 → 942
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:813 → 1140
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      pfam00130
      Location:591 → 640
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    9. NM_001298098.1 → NP_001285027.1  retinal degeneration A, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001285027.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      X2JE67
      Conserved Domains (4) summary
      smart00045
      Location:969 → 1123
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:814 → 942
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:813 → 1140
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      pfam00130
      Location:591 → 640
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

    10. NM_078537.3 → NP_511092.2  retinal degeneration A, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_511092.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A8JV38, A8JV40, Q09103, Q0KHU7, Q7YU71, Q8SY47, Q9W3A4
      Related
      FBpp0291800
      Conserved Domains (7) summary
      smart00045
      Location:964 → 1118
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:814 → 937
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      COG1597
      Location:813 → 1135
      LCB5; Diacylglycerol kinase family enzyme [Lipid transport and metabolism, General function prediction only]
      cd00204
      Location:1324 → 1442
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam00130
      Location:591 → 640
      C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)
      pfam12796
      Location:1325 → 1420
      Ank_2; Ankyrin repeats (3 copies)
      sd00045
      Location:1324 → 1351
      ANK; ANK repeat [structural motif]

    11. NM_001382089.1 → NP_001368977.1  retinal degeneration A, isoform L [Drosophila melanogaster]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A6H2EFG8
      Conserved Domains (4) summary
      smart00045
      Location:969 → 1123
      DAGKa; Diacylglycerol kinase accessory domain (presumed)
      smart00046
      Location:814 → 942
      DAGKc; Diacylglycerol kinase catalytic domain (presumed)
      cd20802
      Location:586 → 647
      C1_DGK_typeIV_rpt1; first protein kinase C conserved region 1 (C1 domain) found in type IV diacylglycerol kinases
      cd20855
      Location:661 → 727
      C1_DGK_typeIV_rpt2; second protein kinase C conserved region 1 (C1 domain) found in type IV diacylglycerol kinases
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A023GPM5 A0A023GPM5
    A0A6H2EFG8 A0A6H2EFG8
    M9MS31 M9MS31
    M9MSN3 M9MSN3
    M9PH20 M9PH20
    M9PHG3 M9PHG3
    Q09103.2 Q09103
    X2JE67 X2JE67
    X2JEJ9 X2JEJ9

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