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    tacc transforming acidic coiled-coil protein [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 40589, updated on 9-Dec-2024

    Summary

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    Official Symbol
    taccprovided by FlyBase
    Official Full Name
    transforming acidic coiled-coil proteinprovided by FlyBase
    Primary source
    FLYBASE:FBgn0026620
    Locus tag
    Dmel_CG9765
    See related
    AllianceGenome:FB:FBgn0026620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    acc; CG9765; d-tacc; D-tacc; D-TACC; Dmel\CG9765; dtacc; dTACC; DTACC; TACC; TACCdm
    Summary
    Predicted to enable microtubule binding activity. Involved in several processes, including microtubule cytoskeleton organization; pole cell formation; and pronuclear migration. Located in astral microtubule; centrosome; and spindle pole. Is expressed in adult head and organism. Orthologous to several human genes including TACC1 (transforming acidic coiled-coil containing protein 1) and TACC3 (transforming acidic coiled-coil containing protein 3). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
    all
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    Genomic context

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    See tacc in Genome Data Viewer
    Location:
    82D2-82D2; 3-47.1 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (4733654..4749056, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (559376..574778, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44923 Neighboring gene Neprilysin 2 Neighboring gene antisense RNA:CR46137 Neighboring gene mir-9384 stem loop Neighboring gene uncharacterized protein Neighboring gene antimeros Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Quantifying post-transcriptional regulation in the development of Drosophila melanogaster. Becker K, et al. Nat Commun, 2018 Nov 26. PMID 30478415, Free PMC Article
    2. D-TACC: a novel centrosomal protein required for normal spindle function in the early Drosophila embryo. Gergely F, et al. EMBO J, 2000 Jan 17. PMID 10637228, Free PMC Article
    3. Centrosome maturation: Aurora lights the way to the poles. Brittle AL, et al. Curr Biol, 2005 Nov 8. PMID 16271861
    4. TACCing down the spindle poles. Theurkauf WE. Nat Cell Biol, 2001 Jul. PMID 11433309
    5. Microtubules concentrate. Wells WA. J Cell Biol, 2001 Jul 9. PMID 11448982, Free PMC Article

    See all (126) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. dTACC restricts bouton addition and regulates microtubule organization at the Drosophila neuromuscular junction.
      Title: dTACC restricts bouton addition and regulates microtubule organization at the Drosophila neuromuscular junction.
    2. Mars mediates spatially controlled dephosphorylation of dTACC, which is critical for spindle stabilization.
      Title: Mars promotes dTACC dephosphorylation on mitotic spindles to ensure spindle stability.
    3. Cnn Motif 1 is necessary for proper recruitment of gamma-tubulin, D-TACC (the homolog of vertebrate transforming acidic coiled-coil proteins [TACC]), and Minispindles (Msps) to embryonic centrosomes
      Title: Proper recruitment of gamma-tubulin and D-TACC/Msps to embryonic Drosophila centrosomes requires Centrosomin Motif 1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    • mir-9384-RA; Dmel\mir-9384-RA; CR46280-RA; Dmel\CR46280-RA
    • mir-9384-RB; Dmel\mir-9384-RB; CR46280-RB; Dmel\CR46280-RB

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables microtubule binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in female meiotic nuclear division TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitotic spindle organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitotic spindle organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in negative regulation of microtubule depolymerization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in nuclear migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pole cell formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in pronuclear fusion TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in pronuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in astral microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in astral microtubule TAS
    Traceable Author Statement
    more info
    		 PubMed 
    colocalizes_with centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle microtubule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in spindle pole IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transforming acidic coiled-coil protein
    Names
    CG9765-PA
    CG9765-PC
    CG9765-PD
    CG9765-PE
    CG9765-PF
    CG9765-PG
    CG9765-PH
    CG9765-PI
    CG9765-PJ
    CG9765-PK
    CG9765-PL
    CG9765-PM
    CG9765-PN
    D. melanogaster transforming acidic coiled coil
    drosophila transforming acidic Coiled-Coil protein
    drosophila transforming acidic coiled-coil
    tacc-PA
    tacc-PC
    tacc-PD
    tacc-PE
    tacc-PF
    tacc-PG
    tacc-PH
    tacc-PI
    tacc-PJ
    tacc-PK
    tacc-PL
    tacc-PM
    tacc-PN
    transforming acidic coiled-coil

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      4733654..4749056 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001202240.2 → NP_001189169.1  transforming acidic coiled-coil protein, isoform K [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189169.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JD97, Q9NJH5
      Conserved Domains (1) summary
      pfam05010
      Location:1103 → 1313
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    2. NM_001202238.2 → NP_001189167.1  transforming acidic coiled-coil protein, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189167.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F0JAL1, Q86BB4
      Conserved Domains (1) summary
      pfam05010
      Location:26 → 236
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    3. NM_001202239.2 → NP_001189168.1  transforming acidic coiled-coil protein, isoform J [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001189168.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4JCV4, Q9NJH5
      Conserved Domains (1) summary
      pfam05010
      Location:994 → 1204
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    4. NM_058086.4 → NP_477434.1  transforming acidic coiled-coil protein, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477434.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q8IPN1, Q9NJH5
      Related
      FBpp0088894
      Conserved Domains (1) summary
      pfam05010
      Location:1007 → 1217
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    5. NM_169016.3 → NP_730867.2  transforming acidic coiled-coil protein, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_730867.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      C7LAF1, Q9NJH5, Q9VN51
      Conserved Domains (1) summary
      pfam05010
      Location:1008 → 1218
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    6. NM_001275333.1 → NP_001262262.1  transforming acidic coiled-coil protein, isoform N [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262262.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6I7, Q9NJH5
      Conserved Domains (1) summary
      pfam05010
      Location:1006 → 1216
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    7. NM_001259986.1 → NP_001246915.1  transforming acidic coiled-coil protein, isoform L [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246915.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4K6I7, Q9NJH5
      Conserved Domains (1) summary
      pfam05010
      Location:1006 → 1216
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    8. NM_176401.2 → NP_788578.1  transforming acidic coiled-coil protein, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788578.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q86BB5, Q9NJH5
      Related
      FBpp0088891
      Conserved Domains (1) summary
      pfam05010
      Location:1074 → 1284
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    9. NM_058085.5 → NP_477433.2  transforming acidic coiled-coil protein, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_477433.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q95TU9, Q9NJH5
      Related
      FBpp0088892
      Conserved Domains (1) summary
      pfam05010
      Location:1089 → 1299
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    10. NM_001275332.1 → NP_001262261.1  transforming acidic coiled-coil protein, isoform M [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262261.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A0B4KFK1, Q9NJH5
      Conserved Domains (1) summary
      pfam05010
      Location:1103 → 1313
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    11. NM_176402.3 → NP_788579.1  transforming acidic coiled-coil protein, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788579.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F0JAL1, Q86BB4
      Related
      FBpp0088888
      Conserved Domains (1) summary
      pfam05010
      Location:26 → 236
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    12. NM_176403.2 → NP_788580.1  transforming acidic coiled-coil protein, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788580.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F0JAL1, Q86BB4
      Related
      FBpp0088890
      Conserved Domains (1) summary
      pfam05010
      Location:26 → 236
      TACC; Transforming acidic coiled-coil-containing protein (TACC)

    13. NM_176404.2 → NP_788581.1  transforming acidic coiled-coil protein, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788581.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F0JAL1, Q86BB4
      Related
      FBpp0088889
      Conserved Domains (1) summary
      pfam05010
      Location:26 → 236
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A0A0B4JCV4 A0A0B4JCV4
    A0A0B4JD97 A0A0B4JD97
    A0A0B4K6I7 A0A0B4K6I7
    A0A0B4KFK1 A0A0B4KFK1
    Q3YNE8 Q3YNE8
    Q86BB4 Q86BB4
    Q86BB5 Q86BB5
    Q8IPN1 Q8IPN1
    Q95TU9 Q95TU9
    Q9NJH5 Q9NJH5
    Q9VN51 Q9VN51
    Q9XZL7 Q9XZL7

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