Cap-H2 Chromosome associated protein H2 [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Cap-H2provided by FlyBase
Official Full Name: Chromosome associated protein H2provided by FlyBase
Primary source: FLYBASE:FBgn0037831
Locus tag: Dmel_CG14685
See related: AllianceGenome:FB:FBgn0037831
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: cap-H2; CAP-H2; CapH2; CAPH2; CG14685; dCap-H2; Dmel\CG14685
Summary: Enables chromatin binding activity. Involved in several processes, including chromatin organization; chromosome separation; and male meiosis chromosome segregation. Predicted to be part of condensin complex. Predicted to be active in nucleus. Is expressed in nurse cell. Orthologous to human NCAPH2 (non-SMC condensin II complex subunit H2). [provided by Alliance of Genome Resources, Dec 2024]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (10761310..10766756)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (6587032..6592478)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

we identify Casein Kinase I alpha (CK1alpha) as an additional negative-regulator of Cap-H2. CK1a-depletion stabilizes Cap-H2 protein and results in an accumulation of Cap-H2 on chromosomes.
Title: Drosophila casein kinase I alpha regulates homolog pairing and genome organization by modulating condensin II subunit Cap-H2 levels.
Cap-h2 interacts with Mrg15 and regulates interphase chromosome compaction.
Title: Maintenance of interphase chromosome compaction and homolog pairing in Drosophila is regulated by the condensin cap-h2 and its partner Mrg15.
Cap-H2 stabilization distorted nuclear envelopes and dispersed Cid/CENP-A on interphase chromosomes.
Title: SCFSlimb ubiquitin ligase suppresses condensin II-mediated nuclear reorganization by degrading Cap-H2.
Cap-H2 is required for nurse cell chromosome territory formation
Title: Condensin II promotes the formation of chromosome territories by inducing axial compaction of polyploid interphase chromosomes.
findings show that condensin II - Cap-H2 promotes disassembly of polytene structure into chromosomal components; Condensin II also negatively regulates transvection
Title: Chromosome alignment and transvection are antagonized by condensin II.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chromatin organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome condensation	IEA Inferred from Electronic Annotation more info
involved_in chromosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chromosome separation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chromosome separation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in male meiosis chromosome segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic chromosome condensation	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic sister chromatid separation	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of condensin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of condensin complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

Names: CG14685-PD; CG14685-PE; CG14685-PF; CG14685-PG; Cap-H2-PD; Cap-H2-PE; Cap-H2-PF; Cap-H2-PG; dCap-H2

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The following sections contain reference sequences that belong to a specific genome build. Explain