U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    unc-95 LIM domain-containing protein unc-95 [ Caenorhabditis elegans ]

    Gene ID: 173301, updated on 9-Dec-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    unc-95
    Official Full Name
    LIM domain-containing protein unc-95
    Primary source
    WormBase:WBGene00006824
    Locus tag
    CELE_Y105E8A.6
    See related
    AllianceGenome:WB:WBGene00006824
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Enables protein domain specific binding activity. Located in M band; nucleus; and striated muscle dense body. Is expressed in anal depressor muscle; anal sphincter muscle; body wall musculature; and vulval muscle. [provided by Alliance of Genome Resources, Dec 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See unc-95 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    5
    Sequence:
    Chromosome: I; NC_003279.8 (14381360..14384737, complement)

    Chromosome I - NC_003279.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Ig-like domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene CUB domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene WD_REPEATS_REGION domain-containing protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003279.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The LIM domain protein UNC-95 is required for the assembly of muscle attachment structures and is regulated by the RING finger protein RNF-5 in C. elegans. Broday L, et al. J Cell Biol, 2004 Jun 21. PMID 15210732, Free PMC Article
    2. Molting-specific downregulation of C. elegans body-wall muscle attachment sites: the role of RNF-5 E3 ligase. Zaidel-Bar R, et al. Biochem Biophys Res Commun, 2010 May 14. PMID 20385102
    3. The SH3 domain of UNC-89 (obscurin) interacts with paramyosin, a coiled-coil protein, in Caenorhabditis elegans muscle. Qadota H, et al. Mol Biol Cell, 2016 May 15. PMID 27009202, Free PMC Article
    4. RNF5, a RING finger protein that regulates cell motility by targeting paxillin ubiquitination and altered localization. Didier C, et al. Mol Cell Biol, 2003 Aug. PMID 12861019, Free PMC Article
    5. High-resolution imaging of muscle attachment structures in Caenorhabditis elegans. Qadota H, et al. Cytoskeleton (Hoboken), 2017 Nov. PMID 28921913, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in M band IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in M band IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in anchoring junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in striated muscle dense body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    LIM domain-containing protein unc-95
    NP_740934.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003279.8 Reference assembly

      Range
      14381360..14384737 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_170938.7 → NP_740934.2  LIM domain-containing protein unc-95 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_740934.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9NEZ5
      Conserved Domains (1) summary
      cd09339
      Location:270 → 328
      LIM4_Paxillin_like; The fourth LIM domain of the Paxillin-like protein family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NEZ5.2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Molecular Biology Databases
    Research Materials
    Tools