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    mdt-8 Mediator of RNA polymerase II transcription subunit 8 [ Caenorhabditis elegans ]

    Gene ID: 174763, updated on 2-Nov-2024

    Summary

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    Official Symbol
    mdt-8
    Official Full Name
    Mediator of RNA polymerase II transcription subunit 8
    Primary source
    WormBase:WBGene00007013
    Locus tag
    CELE_Y62F5A.1
    See related
    AllianceGenome:WB:WBGene00007013
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Caenorhabditis elegans (strain: Bristol N2)
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
    Summary
    Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Is expressed in intestine and pharynx. Orthologous to human MED8 (mediator complex subunit 8). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

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    See mdt-8 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    4
    Sequence:
    Chromosome: II; NC_003280.10 (11527168..11533816, complement)

    Chromosome II - NC_003280.10Genomic Context describing neighboring genes Neighboring gene Major sperm protein Neighboring gene ncRNA Neighboring gene Phosphatidylinositol 3-kinase age-1 Neighboring gene Tyrosine-protein phosphatase domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Reverse transcriptase domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003280.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Proteomic Interactome of C. elegans Mediator Complex Subunit 28 (MDT-28) Reveals Predominant Association with a Restricted Set of Core Mediator Subunits and an Affinity to Additional Structural and Enzymatic Proteins. Yilma P, et al. Folia Biol (Praha), 2019. PMID 32362303
    2. Transcriptional control of cell-cycle quiescence during C. elegans development. Clayton JE, et al. Dev Biol, 2008 Jan 15. PMID 18082681, Free PMC Article
    3. An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. Yang F, et al. Nature, 2006 Aug 10. PMID 16799563
    4. A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Bourbon HM, et al. Mol Cell, 2004 Jun 4. PMID 15175151
    5. Transcription mechanisms. Blackwell TK, et al. WormBook, 2006 Sep 5. PMID 18050436, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by WormBase

    Function Evidence Code Pubs
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of core mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Mediator of RNA polymerase II transcription subunit 8
    NP_496463.2
    • Confirmed by transcript evidence
    NP_496464.2
    • Confirmed by transcript evidence

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003280.10 Reference assembly

      Range
      11527168..11533816 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_064063.5 → NP_496464.2  Mediator of RNA polymerase II transcription subunit 8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496464.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U1W2
      Conserved Domains (1) summary
      pfam10232
      Location:15 → 239
      Med8; Mediator of RNA polymerase II transcription complex subunit 8

    2. NM_064062.5 → NP_496463.2  Mediator of RNA polymerase II transcription subunit 8 [Caenorhabditis elegans]

      See identical proteins and their annotated locations for NP_496463.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9U1W2, Q9U1W3
      Conserved Domains (2) summary
      pfam10232
      Location:15 → 239
      Med8; Mediator of RNA polymerase II transcription complex subunit 8
      cl09930
      Location:241 → 295
      RPA_2b-aaRSs_OBF_like; Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9U1W2.1

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