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    MYO3 myosin 3 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853729, updated on 9-Dec-2024

    Summary

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    Official Symbol
    MYO3
    Official Full Name
    myosin 3
    Primary source
    SGD:S000001612
    Locus tag
    YKL129C
    See related
    AllianceGenome:SGD:S000001612; FungiDB:YKL129C; VEuPathDB:YKL129C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable actin filament binding activity and microfilament motor activity. Involved in actin cortical patch localization and positive regulation of Arp2/3 complex-mediated actin nucleation. Acts upstream of or within reticulophagy. Located in cell periphery. Human ortholog(s) of this gene implicated in focal segmental glomerulosclerosis 6. Orthologous to human MYO1E (myosin IE) and MYO1F (myosin IF). [provided by Alliance of Genome Resources, Dec 2024]
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    Genomic context

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    See MYO3 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (196349..200167, complement)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene putative tetrahydrofolate synthase Neighboring gene She2p Neighboring gene putative phosphomutase Neighboring gene tRNA-Lys

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification and molecular characterization of a yeast myosin I. Goodson HV, et al. Cell Motil Cytoskeleton, 1995. PMID 7728870
    2. New approaches to high-throughput structure characterization of SH3 complexes: the example of Myosin-3 and Myosin-5 SH3 domains from S. cerevisiae. Musi V, et al. Protein Sci, 2006 Apr. PMID 16600966, Free PMC Article
    3. Role of type I myosins in receptor-mediated endocytosis in yeast. Geli MI, et al. Science, 1996 Apr 26. PMID 8614799
    4. Regulation of membrane scission in yeast endocytosis. Menon D, et al. Mol Biol Cell, 2022 Oct 1. PMID 35976707, Free PMC Article
    5. Synthetic lethality screen identifies a novel yeast myosin I gene (MYO5): myosin I proteins are required for polarization of the actin cytoskeleton. Goodson HV, et al. J Cell Biol, 1996 Jun. PMID 8682864, Free PMC Article

    See all (87) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cytoskeletal motor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables microfilament motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables microfilament motor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in actin cortical patch localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in actin cortical patch localization IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in bipolar cellular bud site selection TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in endocytosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in exocytosis TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in fungal-type cell wall organization TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of Arp2/3 complex-mediated actin nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to osmotic stress TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within reticulophagy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in actin cortical patch IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in actin cortical patch IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cortical patch TAS
    Traceable Author Statement
    more info
    		 PubMed 
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell periphery HDA PubMed 
    is_active_in cell tip IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of myosin complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    myosin 3
    NP_012793.2
    • One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization; MYO3 has a paralog, MYO5, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      196349..200167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179695.2 → NP_012793.2  TPA: myosin 3 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012793.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6ZZJ1, D6VX66, P36006
      UniProtKB/TrEMBL
      C8ZC46, G2WHQ8, N1P0R3
      Conserved Domains (1) summary
      COG5022
      Location:1 → 1258
      COG5022; Myosin heavy chain [General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36006.4

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