TGFBR1 transforming growth factor beta receptor 1 [Sus scrofa (pig)] - Gene

Summary

Official Symbol: TGFBR1provided by VGNC
Official Full Name: transforming growth factor beta receptor 1provided by VGNC
Primary source: VGNC:VGNC:98368
See related: Ensembl:ENSSSCG00000005382
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Sus scrofa
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus
Also known as: ALK-5
Expression: Ubiquitous expression in lung (RPKM 23.4), ovary (RPKM 15.0) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	Sscrofa11.1 (GCF_000003025.6)	1	NC_010443.5 (240842735..240918267)
105	previous assembly	Sscrofa10.2 (GCF_000003025.5)	1	NC_010443.4 (269090577..269149183)

Chromosome 1 - NC_010443.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Transcriptome data used for gene annotation
Description: Nine kinds of tissues and a mixture of multiple tissues were sequenced for genome annotation
BioProject: PRJNA311523
Publication: PMID 27646534
Analysis date: Thu Dec 14 17:10:49 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

miR-181a promoted porcine preadipocyte differentiation by directly targeting TGFBR1.
Title: miR-181a regulate porcine preadipocyte differentiation by targeting TGFBR1.
The results indicate that the TGFBR1 gene polymorphism (SNP64) is significantly associated with growth rates including average daily gains between birth and 56 kg, between 5.5 and 56 kg, between 35 and 56 kg.
Title: Association of the porcine transforming growth factor beta type I receptor (TGFBR1) gene with growth and carcass traits.
Report temporal regulation of TGFBR1 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.
Title: Temporal regulation of BMP2, BMP6, BMP15, GDF9, BMPR1A, BMPR1B, BMPR2 and TGFBR1 mRNA expression in the oocyte, granulosa and theca cells of developing preovulatory follicles in the pig.
TGFbeta is abundant in boar seminal plasma, thus TGFbeta may be a male-female signalling agent involved in immune changes in the female reproductive tract elicited by seminal fluid.
Title: Transforming growth factor-β (TGFβ) in porcine seminal plasma.
Porcine transforming growth factor beta receptor 1 has many polymorphisms, including two nonsynonymous substitutions in exons 1 and 7 and novel alternative splicing in exon 3.
Title: Structure and polymorphism analysis of transforming growth factor beta receptor 1 (TGFBR1) in pigs.
isolation and molecular characterization; the full-length TGFBR1 cDNA 1813 bp contains an open reading frame (ORF) of 1512 bp encoding a TGFBR1 protein of 503 amino acids with a calculated molecular weight of 56.4 kDa.
Title: Isolation and molecular characterization of the porcine transforming growth factor beta type I receptor (TGFBR1) gene.

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General gene information

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Markers

Tgfbr1 (e-PCR), detects polymorphism
- UniSTS:507276

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables SMAD binding	IEA Inferred from Electronic Annotation more info	PubMed
enables activin binding	IEA Inferred from Electronic Annotation more info	PubMed
enables activin receptor activity, type I	IEA Inferred from Electronic Annotation more info	PubMed
enables transforming growth factor beta receptor activity, type I	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in activin receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to growth factor stimulus	IEA Inferred from Electronic Annotation more info	PubMed
involved_in heart development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in nervous system development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of activin receptor complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: TGF-beta receptor type-1

Names: TGF-beta receptor type I; TGF-beta type I receptor; TGFR-1; activin A receptor type II-like kinase; tbetaR-I; transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa); transforming growth factor-beta receptor type I

XP_005660327.2

EC 2.7.11.30

XP_020936372.1

EC 2.7.11.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001038639.2 → NP_001033728.2 TGF-beta receptor type-1 precursor

Status: VALIDATED

Source sequence(s)

AEMK02000005, DQ519381

RefSeqs of Annotated Genomes: Sus scrofa Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Sscrofa11.1 Primary Assembly

Genomic

NC_010443.5 Reference Sscrofa11.1 Primary Assembly

Range

240842735..240918267

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021080713.1 → XP_020936372.1 TGF-beta receptor type-1 isoform X2

UniProtKB/TrEMBL

A0A4X1SN23

Related

ENSSSCP00000057115.2, ENSSSCT00000064097.2

Conserved Domains (3) summary

cd14143
Location:144 → 431

STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors

pfam01064
Location:1 → 41

Activin_recp; Activin types I and II receptor domain

pfam08515
Location:111 → 138

TGF_beta_GS; Transforming growth factor beta type I GS-motif
XM_005660270.3 → XP_005660327.2 TGF-beta receptor type-1 isoform X1

UniProtKB/TrEMBL

Q5CD21

Conserved Domains (3) summary

cd14143
Location:251 → 538

STKc_TGFbR1_ACVR1b_ACVR1c; Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta Type I Receptor and Activin Type IB/IC Receptors

pfam01064
Location:76 → 152

Activin_recp; Activin types I and II receptor domain

pfam08515
Location:218 → 245

TGF_beta_GS; Transforming growth factor beta type I GS-motif