Timm17b translocase of inner mitochondrial membrane 17b [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Timm17bprovided by MGI
Official Full Name: translocase of inner mitochondrial membrane 17bprovided by MGI
Primary source: MGI:MGI:1343176
See related: Ensembl:ENSMUSG00000031158 AllianceGenome:MGI:1343176
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sfc3; 17kDa; mTim17b
Summary: Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix. Located in mitochondrial inner membrane. Orthologous to human TIMM17B (translocase of inner mitochondrial membrane 17B). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in adrenal adult (RPKM 27.9), ovary adult (RPKM 20.0) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A1.1; X 3.56 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (7765575..7773891)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (7899336..7907652)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to protein transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein transmembrane transporter activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein import into mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein import into mitochondrial matrix	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of TIM23 mitochondrial import inner membrane translocase complex	IBA Inferred from Biological aspect of Ancestor more info
part_of TIM23 mitochondrial import inner membrane translocase complex	IEA Inferred from Electronic Annotation more info
part_of TIM23 mitochondrial import inner membrane translocase complex	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed

General protein information

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Preferred Names: mitochondrial import inner membrane translocase subunit Tim17-B

Names: translocator of inner mitochondrial membrane 17 kDa, b; translocator of inner mitochondrial membrane 17b; translocator of inner mitochondrial membrane b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001313693.1 → NP_001300622.1 mitochondrial import inner membrane translocase subunit Tim17-B isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate first exon in place of that of variant 1. This difference causes translation initiation at a downstream AUG and results in an isoform (2) with a shorter N-terminus compared to isoform 1.

Source sequence(s)

AK049584, AL670169, W46058

UniProtKB/TrEMBL

Q3UBR8

Conserved Domains (1) summary

cl02381
Location:1 → 149

Tim17; Tim17/Tim22/Tim23/Pmp24 family
NM_011591.5 → NP_035721.1 mitochondrial import inner membrane translocase subunit Tim17-B isoform 1

See identical proteins and their annotated locations for NP_035721.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AK049584, AL670169, AL671978

Consensus CDS

CCDS29978.1

UniProtKB/Swiss-Prot

Q9Z0V7

UniProtKB/TrEMBL

Q3UBR8, Q545H3

Related

ENSMUSP00000033498.4, ENSMUST00000033498.11

Conserved Domains (1) summary

cl02381
Location:1 → 171

Tim17; Tim17/Tim22/Tim23/Pmp24 family

RNA

NR_132589.1 RNA Sequence

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an alternate exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).

Source sequence(s)

AK049584, AL670169, AL671978, BY294049