Cpeb4 cytoplasmic polyadenylation element binding protein 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cpeb4provided by MGI
Official Full Name: cytoplasmic polyadenylation element binding protein 4provided by MGI
Primary source: MGI:MGI:1914829
See related: Ensembl:ENSMUSG00000020300 AllianceGenome:MGI:1914829
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cpeb-4; Cpe-bp4; mCPEB-4
Summary: Enables RNA binding activity. Involved in cellular response to amino acid stimulus and response to ischemia. Located in several cellular components, including dendrite; endoplasmic reticulum; and postsynaptic density. Is expressed in several structures, including central nervous system; dorsal root ganglion; liver; lung; and sensory organ. Orthologous to human CPEB4 (cytoplasmic polyadenylation element binding protein 4). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in liver E14 (RPKM 15.0), liver E14.5 (RPKM 14.5) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 A4; 11 18.66 cM

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (31820911..31885635)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (31870104..31935635)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cpeb4-mediated Dclk2 promotes neuronal pyroptosis induced by chronic cerebral ischemia through phosphorylation of Ehf.
Title: Cpeb4-mediated Dclk2 promotes neuronal pyroptosis induced by chronic cerebral ischemia through phosphorylation of Ehf.
The RNA-binding protein Cpeb4 regulates splicing of the Id2 gene in osteoclast differentiation.
Title: The RNA-binding protein Cpeb4 regulates splicing of the Id2 gene in osteoclast differentiation.
CPEB4-CLOCK crosstalk during temporal lobe epilepsy.
Title: CPEB4-CLOCK crosstalk during temporal lobe epilepsy.
Restoration of CPEB4 prevents muscle stem cell senescence during aging.
Title: Restoration of CPEB4 prevents muscle stem cell senescence during aging.
Pathogenic Mis-splicing of CPEB4 in Schizophrenia.
Title: Pathogenic Mis-splicing of CPEB4 in Schizophrenia.
mmu-microRNA-92a-3p attenuates pulmonary fibrosis by modulating Cpeb4-mediated Smad2/3 signaling pathway.
Title: mmu-microRNA-92a-3p attenuates pulmonary fibrosis by modulating Cpeb4-mediated Smad2/3 signaling pathway.
CPEB4 Increases Expression of PFKFB3 to Induce Glycolysis and Activate Mouse and Human Hepatic Stellate Cells, Promoting Liver Fibrosis.
Title: CPEB4 Increases Expression of PFKFB3 to Induce Glycolysis and Activate Mouse and Human Hepatic Stellate Cells, Promoting Liver Fibrosis.
The RNA-binding protein Cpeb4 is a novel positive regulator of osteoclast differentiation.
Title: The RNA-binding protein Cpeb4 is a novel positive regulator of osteoclast differentiation.
Polyadenylation of mRNA as a novel regulatory mechanism of gene expression in temporal lobe epilepsy.
Title: Polyadenylation of mRNA as a novel regulatory mechanism of gene expression in temporal lobe epilepsy.
that cytoplasmic polyadenylation element-binding protein 4 (CPEB4) acts as a survival factor exclusively for early postnatal granule cells
Title: Olfactory-Experience- and Developmental-Stage-Dependent Control of CPEB4 Regulates c-Fos mRNA Translation for Granule Cell Survival.

Submit: New GeneRIF Correction See all GeneRIFs (16)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (6) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Vbp1 (e-PCR), detects polymorphism
- UniSTS:243274

Cpeb4 (e-PCR), detects polymorphism
- UniSTS:479085

AI851572 (e-PCR)
- UniSTS:165746

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables mRNA 3'-UTR binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA 3'-UTR binding	IEA Inferred from Electronic Annotation more info
enables mRNA regulatory element binding translation repressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables ribosome binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation factor activity, RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables translation regulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in cellular response to amino acid stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to amino acid stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to amino acid stimulus	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to decreased oxygen levels	ISO Inferred from Sequence Orthology more info
involved_in cellular response to decreased oxygen levels	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to glucose starvation	ISO Inferred from Sequence Orthology more info
involved_in cellular response to glucose starvation	ISS Inferred from Sequence or Structural Similarity more info
involved_in ionotropic glutamate receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in ionotropic glutamate receptor signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cytoplasmic translation	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of translation	IEA Inferred from Electronic Annotation more info
involved_in response to ischemia	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	ISO Inferred from Sequence Orthology more info
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in growth cone	IEA Inferred from Electronic Annotation more info
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in postsynapse	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info
located_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: cytoplasmic polyadenylation element-binding protein 4

Names: CPE-binding protein 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001290676.1 → NP_001277605.1 cytoplasmic polyadenylation element-binding protein 4 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) lacks an exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AI845839, AK162101, BC079599, CD803291

UniProtKB/TrEMBL

Q3TSF0

Conserved Domains (3) summary

cd12724
Location:464 → 555

RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:572 → 652

RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

pfam16366
Location:647 → 708

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
NM_001290678.1 → NP_001277607.1 cytoplasmic polyadenylation element-binding protein 4 isoform 3

See identical proteins and their annotated locations for NP_001277607.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks two exons in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.

Source sequence(s)

AI845839, AK162101, BC079599, CD803291

UniProtKB/Swiss-Prot

Q7TN98

UniProtKB/TrEMBL

Q3TSF0

Conserved Domains (3) summary

cd12724
Location:447 → 538

RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:555 → 635

RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

pfam16366
Location:630 → 691

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
NM_026252.4 → NP_080528.2 cytoplasmic polyadenylation element-binding protein 4 isoform 1

See identical proteins and their annotated locations for NP_080528.2

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AI845839, AK162101, BC079599, CF182456

Consensus CDS

CCDS24514.1

UniProtKB/Swiss-Prot

A6H6G0, Q69ZD7, Q7TN98

Related

ENSMUSP00000020543.7, ENSMUST00000020543.13

Conserved Domains (3) summary

cd12724
Location:472 → 563

RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:580 → 660

RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

pfam16366
Location:655 → 716

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000077.7 Reference GRCm39 C57BL/6J

Range

31820911..31885635

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006514793.3 → XP_006514856.1 cytoplasmic polyadenylation element-binding protein 4 isoform X1

UniProtKB/TrEMBL

Q5SU48

Related

ENSMUSP00000105039.3, ENSMUST00000109412.9

Conserved Domains (3) summary

cd12724
Location:455 → 546

RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

cd12726
Location:563 → 643

RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens

pfam16366
Location:638 → 699

CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain