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    ANAPC16 anaphase promoting complex subunit 16 [ Homo sapiens (human) ]

    Gene ID: 119504, updated on 9-Dec-2024

    Summary

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    Official Symbol
    ANAPC16provided by HGNC
    Official Full Name
    anaphase promoting complex subunit 16provided by HGNC
    Primary source
    HGNC:HGNC:26976
    See related
    Ensembl:ENSG00000166295 MIM:613427; AllianceGenome:HGNC:26976
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MSAG; APC16; CENP-27; C10orf104; bA570G20.3
    Summary
    Involved in anaphase-promoting complex-dependent catabolic process and protein polyubiquitination. Located in cytosol and kinetochore. Part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in heart (RPKM 31.6), thyroid (RPKM 26.9) and 25 other tissues See more
    Orthologs
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    Genomic context

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    See ANAPC16 in Genome Data Viewer
    Location:
    10q22.1
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (72216012..72235860)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (73087082..73106898)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (73975770..73995618)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene activating signal cointegrator 1 complex subunit 1 Neighboring gene small nucleolar RNA SNORA36 family Neighboring gene ReSE screen-validated silencer GRCh37_chr10:73950125-73950295 Neighboring gene ribosomal protein L15 pseudogene 14 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:73973271-73973772 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:73973773-73974272 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:73975455-73976450 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:73977030-73977571 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3529 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74007658-74008225 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74008226-74008794 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74008795-74009361 Neighboring gene Sharpr-MPRA regulatory region 8691 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3532 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3533 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74020023-74020666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3534 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3535 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:74030210-74030710 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:74030711-74031211 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74032179-74032702 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:74032703-74033226 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:74035325-74035848 Neighboring gene DDIT4 antisense RNA 1 Neighboring gene DNA damage inducible transcript 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Identification of a novel gene, MSAG, regulated by high levels of glucose and insulin. Cui XY, et al. Biochemistry (Mosc), 2009 Jan. PMID 19232044
    2. Deletion of APC7 or APC16 Allows Proliferation of Human Cells without the Spindle Assembly Checkpoint. Wild T, et al. Cell Rep, 2018 Nov 27. PMID 30485802, Free PMC Article
    3. Isoform Evolution in Primates through Independent Combination of Alternative RNA Processing Events. Zhang SJ, et al. Mol Biol Evol, 2017 Oct 1. PMID 28957512, Free PMC Article
    4. RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1. Chibi M, et al. J Mol Biol, 2008 Dec 26. PMID 18851979
    5. The anaphase-promoting complex: a key factor in the regulation of cell cycle. Castro A, et al. Oncogene, 2005 Jan 13. PMID 15678131

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the contribution of the anaphase-promoting complex/cyclosome subunits APC7 and APC16 to APC/C composition and function in human cells.
      Title: Deletion of APC7 or APC16 Allows Proliferation of Human Cells without the Spindle Assembly Checkpoint.
    2. The structures show how one APC16 binds asymmetrically to the symmetric APC3 dimer and, together with biochemistry and prior data, explain how APC16 recruits APC7 to APC3.
      Title: Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome.
    3. The predicted protein encoded by MSAG contains 110 amino acids and has a theoretical molecular weight of 11667.04 and an isoelectric point of 4.91 (MSAG).
      Title: Identification of a novel gene, MSAG, regulated by high levels of glucose and insulin.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ33728

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anaphase-promoting complex-dependent catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in anaphase-promoting complex-dependent catabolic process NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K11-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein K48-linked ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein branched polyubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of meiotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of mitotic cell cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of anaphase-promoting complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of anaphase-promoting complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of anaphase-promoting complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    part_of anaphase-promoting complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    is_active_in kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    anaphase-promoting complex subunit 16
    Names
    centromere protein 27
    cyclosome subunit 16
    metabolic syndrome-associated protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001242546.2 → NP_001229475.1  anaphase-promoting complex subunit 16 isoform 1

      See identical proteins and their annotated locations for NP_001229475.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1. Variants 1-3 encode the same protein (isoform 1).
      Source sequence(s)
      AL607035, CD724246, DA739927
      Consensus CDS
      CCDS7314.1
      UniProtKB/Swiss-Prot
      Q96DE5
      UniProtKB/TrEMBL
      C5H3H2
      Related
      ENSP00000477760.1, ENST00000621663.4
      Conserved Domains (1) summary
      pfam17256
      Location:27 → 106
      ANAPC16; Anaphase Promoting Complex Subunit 16

    2. NM_001242547.2 → NP_001229476.1  anaphase-promoting complex subunit 16 isoform 1

      See identical proteins and their annotated locations for NP_001229476.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1-3 encode the same protein (isoform 1).
      Source sequence(s)
      AL607035, CD511334, CD724246
      Consensus CDS
      CCDS7314.1
      UniProtKB/Swiss-Prot
      Q96DE5
      UniProtKB/TrEMBL
      C5H3H2
      Conserved Domains (1) summary
      pfam17256
      Location:27 → 106
      ANAPC16; Anaphase Promoting Complex Subunit 16

    3. NM_001242548.2 → NP_001229477.1  anaphase-promoting complex subunit 16 isoform 2

      See identical proteins and their annotated locations for NP_001229477.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences in the 5' UTR and lacks an in-frame exon in the coding region, compared to variant 1, which results in a shorter protein (isoform 2), compared to isoform 1.
      Source sequence(s)
      AL607035, CB984695, CD724246, DA739927
      Consensus CDS
      CCDS73147.1
      UniProtKB/TrEMBL
      A0A087WUN5
      Related
      ENSP00000478792.1, ENST00000615507.4
      Conserved Domains (1) summary
      pfam17256
      Location:27 → 81
      ANAPC16; Anaphase Promoting Complex Subunit 16

    4. NM_001366791.1 → NP_001353720.1  anaphase-promoting complex subunit 16 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL607035
      Consensus CDS
      CCDS7314.1
      UniProtKB/Swiss-Prot
      Q96DE5
      UniProtKB/TrEMBL
      C5H3H2
      Conserved Domains (1) summary
      pfam17256
      Location:27 → 106
      ANAPC16; Anaphase Promoting Complex Subunit 16

    5. NM_173473.4 → NP_775744.1  anaphase-promoting complex subunit 16 isoform 1

      See identical proteins and their annotated locations for NP_775744.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1, and encodes isoform 1. Variants 1-3 encode the same protein (isoform 1).
      Source sequence(s)
      AL607035, CD724246, DA739927
      Consensus CDS
      CCDS7314.1
      UniProtKB/Swiss-Prot
      Q96DE5
      UniProtKB/TrEMBL
      C5H3H2
      Related
      ENSP00000299381.3, ENST00000299381.5
      Conserved Domains (1) summary
      pfam17256
      Location:27 → 106
      ANAPC16; Anaphase Promoting Complex Subunit 16

    RNA

    1. NR_038391.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) lacks multiple exons at the 5' end, compared to variant 1, which results in the loss of the start codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated.
      Source sequence(s)
      AL607035, CD724246, DA310509

    2. NR_038392.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) lacks multiple exons at the 5' end, compared to variant 1, which results in the loss of the start codon. The transcript is sufficiently abundant to represent as a RefSeq record; however, the predicted protein is not represented because the product is significantly truncated.
      Source sequence(s)
      AL607035, BM768948, CD724246, DA739927

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      72216012..72235860
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424580.1 → XP_047280536.1  anaphase-promoting complex subunit 16 isoform X1

      UniProtKB/Swiss-Prot
      Q96DE5
      UniProtKB/TrEMBL
      C5H3H2

    2. XM_047424582.1 → XP_047280538.1  anaphase-promoting complex subunit 16 isoform X1

      UniProtKB/Swiss-Prot
      Q96DE5
      UniProtKB/TrEMBL
      C5H3H2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      73087082..73106898
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054364752.1 → XP_054220727.1  anaphase-promoting complex subunit 16 isoform X1

      UniProtKB/Swiss-Prot
      Q96DE5
      UniProtKB/TrEMBL
      C5H3H2

    2. XM_054364753.1 → XP_054220728.1  anaphase-promoting complex subunit 16 isoform X1

      UniProtKB/Swiss-Prot
      Q96DE5
      UniProtKB/TrEMBL
      C5H3H2
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96DE5.1 GenPept UniProtKB/Swiss-Prot:Q96DE5

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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