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    Gbx1 gastrulation brain homeobox 1 [ Mus musculus (house mouse) ]

    Gene ID: 231044, updated on 27-Nov-2024

    Summary

    Official Symbol
    Gbx1provided by MGI
    Official Full Name
    gastrulation brain homeobox 1provided by MGI
    Primary source
    MGI:MGI:95667
    See related
    Ensembl:ENSMUSG00000067724 AllianceGenome:MGI:95667
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gbx-1
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within adult walking behavior; neuron differentiation; and proprioception. Located in nucleus. Is expressed in several structures, including central nervous system; embryo mesenchyme; extraembryonic component; eye; and male reproductive gland or organ. Orthologous to human GBX1 (gastrulation brain homeobox 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E14 (RPKM 1.1), whole brain E14.5 (RPKM 1.0) and 5 other tissues See more
    Orthologs
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    Genomic context

    See Gbx1 in Genome Data Viewer
    Location:
    5 A3; 5 11.93 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (24709424..24731846, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (24504426..24526848, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene transmembrane and ubiquitin-like domain containing 1 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 3 Neighboring gene VISTA enhancer mm1191 Neighboring gene STARR-positive B cell enhancer mm9_chr5:24035915-24036216 Neighboring gene ankyrin repeat and SOCS box-containing 10 Neighboring gene IQ motif containing with AAA domain 1 like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (5)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    homeobox protein GBX-1
    Names
    gastrulation and brain-specific homeobox protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_015739.2NP_056554.1  homeobox protein GBX-1

      See identical proteins and their annotated locations for NP_056554.1

      Status: PROVISIONAL

      Source sequence(s)
      AC120353
      Consensus CDS
      CCDS19123.1
      UniProtKB/Swiss-Prot
      P82976, Q8CGW5
      Related
      ENSMUSP00000085651.5, ENSMUST00000088311.6
      Conserved Domains (1) summary
      pfam00046
      Location:319372
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      24709424..24731846 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)